Pfizer

  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:69c29379d74caac9ba47c47088d6b60a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<ol>\n<li>Quantify how much PD-0332334 is removed from the blood with hemodialysis</li>\n<li>Investigate the pharmacokinetics of a single dose of PD-0332334 in subjects receiving regular hemodialysis treatments.</li>\n<li>Investigate the safety and tolerability of a single dose of PD-0332334 in subjects receiving hemodialysis.</li>\n</ol>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:69c29379d74caac9ba47c47088d6b60a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:753e2984f6acafb547d13fac64f7ab47' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase I, Open-Label, Single Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of PD-0332334 In Subjects Receiving Chronic Hemodialysis</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:753e2984f6acafb547d13fac64f7ab47' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d86f08aaa8dc5d6730f6af2ff5fb0c02' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Assess the elimination of PD-0332334 from the blood with hemodialysis</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:d86f08aaa8dc5d6730f6af2ff5fb0c02' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d8bc29fa5c25adab22e72821b3baef98' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Patients receiving regular hemodialysis</li>\n<li>Male or female patients 18 to 65 years</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Severe heart failure</li>\n<li>Renal transplant or renal allograft</li>\n<li>Illicit drug use (with the exception of prescribed sedatives)</li>\n</ul>\n</p>', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:d8bc29fa5c25adab22e72821b3baef98' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:76420b71b7014b8ac62b2b0015202cbe' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The study is being conducted to determine the maximum tolerated dose, overall safety and tolerability profile, and pharmacokinetic profile of CP-751,871 and sunitinib when given in combination with advanced solid tumors.</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:76420b71b7014b8ac62b2b0015202cbe' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:08e8b4c3ef714f87af7e221df8be8cf1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Phase 1, Open Label, Sequential Cohort, Dose Escalation Study of CP-751,871 in Combination With Sunitinib in Patients With Advanced Solid Tumors</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:08e8b4c3ef714f87af7e221df8be8cf1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:65bcc2f42bcd9f0d94b35d7ec59d63e6' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Histologically or cytologically confirmed advanced solid tumors relapsed or refractory to standard therapy or for whom no standard therapy exists.</li>\n<li>ECOG Performance Status of 0, 1, or 2</li>\n<li>Adequate bone marrow, renal, and hepatic function</li>\n<li>No mitral valve regurgitation greater than mild as determined by Doppler echocardiogram</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Concurrent treatment with any antitumor agents with the exception of LHRH agnosits for prostate cancer patients</li>\n<li>treatment with any other investigational therapy within 4 weeks prior to study treatment</li>\n<li>Major surgery within 4 weeks of study treatment</li>\n<li>Ongoing cardiac dysrhythmias of NCI CTCAE Grade 2 or greater</li>\n<li>Significant active cardiac disease</li>\n</ul>\n</p>', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:65bcc2f42bcd9f0d94b35d7ec59d63e6' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5236f91076423496cd5a1cad956c9154' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To evaluate the potential development of Anti-Drug Antibodies (ADA) in response to CP-751,871 [&nbsp;Time&nbsp;Frame:&nbsp;15Jan10&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:5236f91076423496cd5a1cad956c9154' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:970d97414dceb558e5b30830736d31c1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To document evidence of antitumor activity in patients with measurable disease, of CP-751,871 when given in combination with sunitinib [&nbsp;Time&nbsp;Frame:&nbsp;15Jan10&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:970d97414dceb558e5b30830736d31c1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:13f8d763a3af790eaeac5bf81a14f859' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To characterize the PK of CP-751,871 and sunitinib (and its metabolite SU012662) when given in combination [&nbsp;Time&nbsp;Frame:&nbsp;15Jan10&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:13f8d763a3af790eaeac5bf81a14f859' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bcf0c60d4e279e09adde30fe78b1954a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To define the overall safety and tolerability profile of CP-751,871 and sunitinib when given in combination [&nbsp;Time&nbsp;Frame:&nbsp;15Jan10&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573230, expire = 1283659630, headers = '', serialized = 0 WHERE cid = '1:bcf0c60d4e279e09adde30fe78b1954a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:281f27286b0a877603f75ff7d16d84e7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This present study is specifically designed to examine the efficacy and safety of a high pre-treatment dose of atorvastatin in Asian patients with NSTE-ACS in China and the Republic of Korea, by using a treatment paradigm similar to that employed in the ARMYDA-ACS study.</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:281f27286b0a877603f75ff7d16d84e7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:49f8e60d3b1c81a46abdcef01772129a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Prospective Randomized, Open-Label, Parallel-Group Comparative Study: Atorvastatin Pre-Treatment Versus Usual Care In Asian Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Coronary Intervention</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:49f8e60d3b1c81a46abdcef01772129a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a5aeb8b28aae79eb2346c02357e063dc' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Non-ST elevated ACS; LDL-C &gt; 80 mg/dl</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>ST elevated acute myocardial infarction; previously or currently treated with atorvastatin or other statins</li>\n</ul>\n</p>', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:a5aeb8b28aae79eb2346c02357e063dc' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c71e356840773ad53cc025df515f58be' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Safety and tolerability profile of atorvastatin [&nbsp;Time&nbsp;Frame:&nbsp;30 days after PCI&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:c71e356840773ad53cc025df515f58be' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5e4434f624f0fd9793ef3f6e0c25198d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Incidence of MACE [&nbsp;Time&nbsp;Frame:&nbsp;8 hours and 24 hours post PCI&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:5e4434f624f0fd9793ef3f6e0c25198d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:296a4c05c95369da5201d9e5c28e1f5c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Proportion of patients who have any elevated biomarkers of myocardial injury above normal range [&nbsp;Time&nbsp;Frame:&nbsp;8 hours, 24 hours and 30 days post PCI&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:296a4c05c95369da5201d9e5c28e1f5c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9601d6cc181f71bfb4b81828cc0c5cf9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Change from baseline in C-Reactive Protein (CRP) [&nbsp;Time&nbsp;Frame:&nbsp;8 hours, 24 hours and 30 days&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:9601d6cc181f71bfb4b81828cc0c5cf9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:26fd9fef0ef7d7b4e58b0f5a73c09138' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>EGAST 2008 is a prospective, non interventional, multicentric study (approximately 2000 isolates from 15- 20 sites). Objectives:\n<ul>\n<li>Comparison of antimicrobial susceptibility using disc-diffusion method</li>\n<li>Assessing prevalence of beta-lactamase producing strains among clinical isolates obtained from hospital in-patients</li>\n</ul>\n</p>', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:26fd9fef0ef7d7b4e58b0f5a73c09138' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a85065490ba8b3020432a336d8670c4a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Expert Group On Antibiotic Susceptibility Testing [EGAST] 2008: A Non-Interventional, Multicenter In-Vitro Study To Evaluate The Prevalence Of Beta-Lactamase Producing Strains Among Clinical Isolates Obtained From Hospital In-Patients And Comparison Of An</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:a85065490ba8b3020432a336d8670c4a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b9984f0a190145c5e74892e9c65fd0b0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria: Isolates (as specified in the observational plan) from hospitalised patients Exclusion Criteria: Isolates obtained from outpatients will not be included for the study. Isolates from repeat cultures performed during in-patient follow-up that were previously recruited into the study will be excluded. Isolates identified as commensals or contaminants will be excluded</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:b9984f0a190145c5e74892e9c65fd0b0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7fc0894e8e325dea672758aa19c0a19d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Research in test tubes suggests that may affect cytochrome P450 2D6 (CYP2D6), an important enzyme that is responsible for eliminating many drugs that cancer patients need to take, including dextromethorphan. The purpose of this study is to test the impact of PF-00299804 on the activity of CYP2D6, and how the human body handles dextromethorphan.</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:7fc0894e8e325dea672758aa19c0a19d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:63f528524292b470b22e7ac812f8c74c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase 1, Open Label, Single Arm Trial To Evaluate The Effect Of PF- 00299804 On The Pharmacokinetics Of Dextromethorphan In Patients With Advanced Malignant Solid Tumors</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:63f528524292b470b22e7ac812f8c74c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8dee330ffae58ae335453e04ffecbcb5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Patients with a histologically or cytologically confirmed advanced malignant solid tumor for which there is no currently approved treatment or which is unresponsive to currently approved therapies;</li>\n<li>Eastern Cooperative Oncology Group (ECOG) performance status 0-1. Patients with performance status 2 could be eligible upon agreement between sponsors and investigators;</li>\n<li>Adequate bone marrow, renal, liver and cardiac functions;</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>History of Interstitial Lung Disease (ILD).</li>\n<li>Drugs with known CYP2D6 inhibitory effects</li>\n<li>Drugs that are highly dependent on CYP2D6 for metabolism.</li>\n<li>Women who are pregnant or breastfeeding.</li>\n</ul>\n</p>', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:8dee330ffae58ae335453e04ffecbcb5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:798cd59a23dd322af20169fb8ffab49a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Plasma dextromethorphan: dextrorphan AUC ratios, and urinary dextromethorphan : dextrorphan ratios [&nbsp;Time&nbsp;Frame:&nbsp;01-30-2009&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:798cd59a23dd322af20169fb8ffab49a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:575d85b1b6bf8057405ff1a0fa71a53f' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will explore the combination of the oral drug PF-00299804 and intravenous CP-751,871 in patients with advanced solid tumor. Each of these drugs have been given separately to patients in prior studies, and this study is to establish the safety and efficacy of the combination</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:575d85b1b6bf8057405ff1a0fa71a53f' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0d4e4e46661f401546f86348343ba1a1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Phase 1 Targeted Combination Trial Of PF-00299804 And CP-751,871 In Patients With Advanced Solid Tumors</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:0d4e4e46661f401546f86348343ba1a1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3276e330f2f26e2bf6015282097b2001' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Histologically documented advanced cancer, ECOG 0-1;</li>\n<li>Platelets &gt; 100,000, ANC &gt; 1500;</li>\n<li>Ccr &gt; 60 or serum creat. &lt;1.5</li>\n<li>Non-small cell cancer cohort:</li>\n<li>ECOG 0-2, prior platin, &lt; 4 prior chemotherapy regimen</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Active CNS metastases;</li>\n<li>prior IGF1-R targeted therapy</li>\n</ul>\n</p>', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:3276e330f2f26e2bf6015282097b2001' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5f5b4bf14f54d65242abb4a6b4000577' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Plasma Pharmacokinetic Parameters of PF-00299804 and CP-751,871 [&nbsp;Time&nbsp;Frame:&nbsp;12 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:5f5b4bf14f54d65242abb4a6b4000577' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a024e41f0241ea739ad971e36c0cfb23' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Progression Free Survival (PFS) [&nbsp;Time&nbsp;Frame:&nbsp;15 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:a024e41f0241ea739ad971e36c0cfb23' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f5c4a4b5e5f24141fad44c2766fc5836' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Best overall response (OR) defined according to RECIST guidelines. [&nbsp;Time&nbsp;Frame:&nbsp;12 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:f5c4a4b5e5f24141fad44c2766fc5836' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:83c7b58ffaa6f4c71d08d3b8b5a3d9c9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Duration of response (DR) [&nbsp;Time&nbsp;Frame:&nbsp;15 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:83c7b58ffaa6f4c71d08d3b8b5a3d9c9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7001ec3496aa81f9fee7bdf6b4d5bbd7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Anti-Drug Antibodies (ADA) response; [&nbsp;Time&nbsp;Frame:&nbsp;18 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:7001ec3496aa81f9fee7bdf6b4d5bbd7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:aa94ad09dca98ae2964b0529841fbd92' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>KRAS mutation and EGFR gene amplification and mutation status in available NSCLC tumor tissue (fresh or archived) (NSCLC MTD Expansion Cohort [&nbsp;Time&nbsp;Frame:&nbsp;12 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:aa94ad09dca98ae2964b0529841fbd92' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:432c6e610f25da41ef881b67c47c85d5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study designed to evaluate the pharmacokinetics and safety of AG-013736 at single doses and multiple doses</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:432c6e610f25da41ef881b67c47c85d5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4efb420485fe43ec788d56c844aa4081' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase 1 Study In Patients With Advanced Solid Tumor To Evaluate The Pharmacokinetics And Safety Of AG-013736 At Single Doses Of 5 mg, 7 mg And 10 mg, And At Multiple Doses</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:4efb420485fe43ec788d56c844aa4081' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8ab1a7d977b7df9318594c8a08574761' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Patients histologically or cytologically diagnosed with advanced solid tumors</li>\n<li>Patients for whom standard therapies have not been effective, or for whom there are no suitable therapies</li>\n<li>Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0, 1 or 2</li>\n<li>Patients with no uncontrolled hypertension</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Patients who have central lung lesions involving major blood vessels</li>\n<li>Patients who require anticoagulant therapy.</li>\n<li>Patients with active epilepsy seizure or symptoms, with brain metastases requiring treatment, with spinal cord compression and with carcinomatous meningitis.</li>\n</ul>\n</p>', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:8ab1a7d977b7df9318594c8a08574761' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:feb18bc4a605ca3889afea40f054d794' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Adverse events [&nbsp;Time&nbsp;Frame:&nbsp;End of study&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:feb18bc4a605ca3889afea40f054d794' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:48383e504f7e3e4c3b68b199000c3198' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Plasma pharmacokinetics of AG-013736 following multiple dosing [&nbsp;Time&nbsp;Frame:&nbsp;End of study&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:48383e504f7e3e4c3b68b199000c3198' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:23166561bd56d6a3b292f07211540b88' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Pharmacodynamic indices [&nbsp;Time&nbsp;Frame:&nbsp;End of study&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:23166561bd56d6a3b292f07211540b88' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:786654e2cbf7ae81164c787063b02d83' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Anti-tumor effect [&nbsp;Time&nbsp;Frame:&nbsp;End of study&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:786654e2cbf7ae81164c787063b02d83' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:683e368dcd41fd56297e9728c4e64c6d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The aim of the study is to evaluate whether PF-04523655 is safe in the treatment of neovascular/wet AMD</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:683e368dcd41fd56297e9728c4e64c6d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:590a674515a2bee4ba1bd8fad34fe215' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To describe anatomical changes in the retina and choroid following the administration of PF-04523655 [&nbsp;Time&nbsp;Frame:&nbsp;Day 14&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:590a674515a2bee4ba1bd8fad34fe215' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9de5fc2f7c296b40f063dcb81ffdf4fc' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To determine the changes in visual acuity ETDRS chart after a single intravitreal injection of PF-04523655 [&nbsp;Time&nbsp;Frame:&nbsp;Day 14&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:9de5fc2f7c296b40f063dcb81ffdf4fc' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b82b3c4b112a5b9e61107bec349aeb8e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This local registration study is to confirm the hypothesis of the efficacy, tolerability and safety of ziprasidone IM (intramuscular) in the Chinese population with agitation in schizophrenia</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:b82b3c4b112a5b9e61107bec349aeb8e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:45b219c9ffdfdf28f746369294244606' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Randomized, Open Label, Rater Blind, Flexible Dose Multi-Center Study Comparing The Efficacy And Safety Of Intramuscular Ziprasidone With Haloperidol For Three Days In Patients With Agitation Of Schizophrenia</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:45b219c9ffdfdf28f746369294244606' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2ea7c825c56014bbb717655193868dc9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Male or female Chinese subjects aged 18-65 years (including 65) at screening.</li>\n<li>Subjects meeting the ICD-10 (Classification of Mental and Behavioral Disorders) criteria for schizophrenia (F20.X).</li>\n<li>Subjects who are in acute phase of schizophrenia and are appropriate to receive intramuscular medication for at least 3 days</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>History of clinically significant physical illness especially myocardial infarction, non compensatory heart failure etc.</li>\n<li>Subjects receiving an investigational agent in the previous 3 months prior to screening.</li>\n<li>Use of antipsychotic agents within 12 hours or parenteral benzodiazepines within 4 hours prior to randomization and during the study.</li>\n</ul>\n</p>', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:2ea7c825c56014bbb717655193868dc9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e4002d9c4d982de7f8fd8c03d10494ea' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The responder rates of BPRS agitation subscale score from baseline to the end of study [&nbsp;Time&nbsp;Frame:&nbsp;72 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:e4002d9c4d982de7f8fd8c03d10494ea' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c85094fe69b827aca387f9c3934daae8' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Secondary endpoints include end of study change from baseline in Behavioral Activity Rating Scale (BARS), and in BPRS agitation subscale score. [&nbsp;Time&nbsp;Frame:&nbsp;72 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:c85094fe69b827aca387f9c3934daae8' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b1e6ed7ef0ebc11f051c0ae4c3dff666' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Score change from baseline to the end of study in CGI-I (Improvement) and CGI Severity (CGI-S) [&nbsp;Time&nbsp;Frame:&nbsp;72 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:b1e6ed7ef0ebc11f051c0ae4c3dff666' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:373fe9f2fc8f667ece999ccc537df76b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Safety and tolerability evaluation [&nbsp;Time&nbsp;Frame:&nbsp;72 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:373fe9f2fc8f667ece999ccc537df76b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:64908f124fe0c710a1e28b71c969c0ad' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Study to determine the bronchodilatory effects of PF-04191834 compared with zileuton in patients with asthma</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:64908f124fe0c710a1e28b71c969c0ad' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7970dc555aa34a97dfa0b31e4a5ce405' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase 2a, Randomised, Double-Blind (3rd Party Open), Double-Dummy, Placebo And Active Controlled 5-Way Crossover Study To Assess The Bronchodilatory Action, Safety, Toleration And Pharmacokinetics Of Single Oral Doses Of PF-04191834 In Asthmatic Patient</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:7970dc555aa34a97dfa0b31e4a5ce405' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d49c78882f9cc62647cc30810262814a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Persistent mild/moderate asthma for at least 6 months.</li>\n<li>Reduced lung function</li>\n<li>Reversible airway obstruction</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Pregnant/nursing females.</li>\n<li>Liver function tests greater than upper limit of normal (ULN)</li>\n</ul>\n</p>', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:d49c78882f9cc62647cc30810262814a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9bb1aba1c1a677eac9eb7f307732d848' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Pharmacokinetics [&nbsp;Time&nbsp;Frame:&nbsp;24 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:9bb1aba1c1a677eac9eb7f307732d848' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f4a84aa61286a9c9b5d3d54a4733c273' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Safety and toleration [&nbsp;Time&nbsp;Frame:&nbsp;24 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283573231, expire = 1283659631, headers = '', serialized = 0 WHERE cid = '1:f4a84aa61286a9c9b5d3d54a4733c273' in /persistent/html/includes/cache.inc on line 109.

A Single Dose Study Investigating The Elimination Of PD-0332334 In Patients Receiving Regular Hemodialysis

Trial phase: 
Phase I
Recruitment status: 
Completed
  1. Quantify how much PD-0332334 is removed from the blood with hemodialysis
  2. Investigate the pharmacokinetics of a single dose of PD-0332334 in subjects receiving regular hemodialysis treatments.
  3. Investigate the safety and tolerability of a single dose of PD-0332334 in subjects receiving hemodialysis.
Background information
Trial ID: 
NCT00730145
Other unique IDs: 
A5361032
Official title: 

A Phase I, Open-Label, Single Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of PD-0332334 In Subjects Receiving Chronic Hemodialysis

Detailed description: 

Assess the elimination of PD-0332334 from the blood with hemodialysis

Number to be enrolled: 
8 patients

Study of CP-751,871 in Combination With Sunitinib in Patients With Advanced Solid Tumors

Trial phase: 
Phase I
Recruitment status: 
Recruiting

The study is being conducted to determine the maximum tolerated dose, overall safety and tolerability profile, and pharmacokinetic profile of CP-751,871 and sunitinib when given in combination with advanced solid tumors.

Background information
Trial ID: 
NCT00729833
Other unique IDs: 
A4021024
Official title: 

Phase 1, Open Label, Sequential Cohort, Dose Escalation Study of CP-751,871 in Combination With Sunitinib in Patients With Advanced Solid Tumors

Detailed description: 

 

Number to be enrolled: 
45 patients

Atorvastatin Pre-Treatment Study In Asian Patients With Acute Coronary Syndrome

Trial phase: 
Phase IV
Recruitment status: 
Recruiting

This present study is specifically designed to examine the efficacy and safety of a high pre-treatment dose of atorvastatin in Asian patients with NSTE-ACS in China and the Republic of Korea, by using a treatment paradigm similar to that employed in the ARMYDA-ACS study.

Background information
Trial ID: 
NCT00728988
Other unique IDs: 
A2581161
Official title: 

A Prospective Randomized, Open-Label, Parallel-Group Comparative Study: Atorvastatin Pre-Treatment Versus Usual Care In Asian Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Coronary Intervention

Detailed description: 

 

Number to be enrolled: 
350 patients
Acronym: 
ALPACS

Assessing Prevalence Of Beta Lactamase Production From Clinical Isolates Of Hospitalized Patients And Comparison Of Antibiotic Susceptibility Patterns

Trial phase: 
Phase 0
Recruitment status: 
Recruiting

EGAST 2008 is a prospective, non interventional, multicentric study (approximately 2000 isolates from 15- 20 sites). Objectives:

  • Comparison of antimicrobial susceptibility using disc-diffusion method
  • Assessing prevalence of beta-lactamase producing strains among clinical isolates obtained from hospital in-patients

Background information
Trial ID: 
NCT00728624
Other unique IDs: 
A1891005
Official title: 

Expert Group On Antibiotic Susceptibility Testing [EGAST] 2008: A Non-Interventional, Multicenter In-Vitro Study To Evaluate The Prevalence Of Beta-Lactamase Producing Strains Among Clinical Isolates Obtained From Hospital In-Patients And Comparison Of An

Detailed description: 

 

Number to be enrolled: 
2000 patients
Acronym: 
EGAST 2008

A Study To Test The Impact Of PF- 00299804 On How The Body Handles Dextromethorphan In Cancer Patients

Trial phase: 
Phase I
Recruitment status: 
Recruiting

Research in test tubes suggests that may affect cytochrome P450 2D6 (CYP2D6), an important enzyme that is responsible for eliminating many drugs that cancer patients need to take, including dextromethorphan. The purpose of this study is to test the impact of PF-00299804 on the activity of CYP2D6, and how the human body handles dextromethorphan.

Background information
Trial ID: 
NCT00728468
Other unique IDs: 
A7471014
Official title: 

A Phase 1, Open Label, Single Arm Trial To Evaluate The Effect Of PF- 00299804 On The Pharmacokinetics Of Dextromethorphan In Patients With Advanced Malignant Solid Tumors

Detailed description: 

 

Number to be enrolled: 
18 patients

A Safety And Efficacy Study Of The Combination Of Oral PF-00299804 And Intravenous CP-751,871 Given Every 3 Weeks

Trial phase: 
Phase I
Recruitment status: 
Recruiting

This study will explore the combination of the oral drug PF-00299804 and intravenous CP-751,871 in patients with advanced solid tumor. Each of these drugs have been given separately to patients in prior studies, and this study is to establish the safety and efficacy of the combination

Background information
Trial ID: 
NCT00728390
Other unique IDs: 
A7471004
Official title: 

Phase 1 Targeted Combination Trial Of PF-00299804 And CP-751,871 In Patients With Advanced Solid Tumors

Detailed description: 

 

Number to be enrolled: 
45 patients

A Study In Patients With Advanced Solid Tumor

Trial phase: 
Phase I
Recruitment status: 
Active, not recruiting

This study designed to evaluate the pharmacokinetics and safety of AG-013736 at single doses and multiple doses

Background information
Trial ID: 
NCT00726752
Other unique IDs: 
A4061044
Official title: 

A Phase 1 Study In Patients With Advanced Solid Tumor To Evaluate The Pharmacokinetics And Safety Of AG-013736 At Single Doses Of 5 mg, 7 mg And 10 mg, And At Multiple Doses

Detailed description: 

 

Number to be enrolled: 
6 patients

A Randomized, Open-Label, Multi-Center Study To Evaluate The Efficacy And Safety Of Intramuscular Ziprasidone In Patients With Agitation

Trial phase: 
Phase III
Recruitment status: 
Recruiting

This local registration study is to confirm the hypothesis of the efficacy, tolerability and safety of ziprasidone IM (intramuscular) in the Chinese population with agitation in schizophrenia

Background information
Trial ID: 
NCT00723606
Other unique IDs: 
A1281152
Official title: 

A Randomized, Open Label, Rater Blind, Flexible Dose Multi-Center Study Comparing The Efficacy And Safety Of Intramuscular Ziprasidone With Haloperidol For Three Days In Patients With Agitation Of Schizophrenia

Detailed description: 

 

Number to be enrolled: 
364 patients

PF-04191834 Single Dose Bronchodilatory Study In Asthma.

Trial phase: 
Phase II
Recruitment status: 
Recruiting

Study to determine the bronchodilatory effects of PF-04191834 compared with zileuton in patients with asthma

Background information
Trial ID: 
NCT00723021
Other unique IDs: 
B0041002
Official title: 

A Phase 2a, Randomised, Double-Blind (3rd Party Open), Double-Dummy, Placebo And Active Controlled 5-Way Crossover Study To Assess The Bronchodilatory Action, Safety, Toleration And Pharmacokinetics Of Single Oral Doses Of PF-04191834 In Asthmatic Patient

Detailed description: 

 

Number to be enrolled: 
15 patients
Syndicate content