Novo Nordisk

  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2e003114a82fe834135e7d80f836a189' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study is conducted in Europe. The study aims to observe the incidence of serious adverse drug reactions in patients with type 2 diabetes during NovoMix&#174; 30 treatment.</p>\n', created = 1283939934, expire = 1284026334, headers = '', serialized = 0 WHERE cid = '1:2e003114a82fe834135e7d80f836a189' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6ea551417afc82afb5cd5d92b5189b08' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Safety of NovoMix&#174; 30 (Biphasic Insulin Aspart) Treatment in Patients With Type 2 Diabetes</p>\n', created = 1283939934, expire = 1284026334, headers = '', serialized = 0 WHERE cid = '1:6ea551417afc82afb5cd5d92b5189b08' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9f8c788a95d88154b2c41baabda0a171' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Any patient with diabetes type 2 diabetes</li>\n<li>Currently treated with basal human insulin therapy (basal only or in combination with oral glucose lowering drugs or other insulin</li>\n<li>Selection of patients will be at the discretion of the treating physician after the decision to prescribe one of the study products to the patient</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Known or suspected allergy to study product(s) or related products</li>\n<li>Pregnancy, breast-feeding or intention of becoming pregnant within the next 6 months</li>\n</ul>\n</p>', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:9f8c788a95d88154b2c41baabda0a171' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3c72b206c2eea0bdbc6a10da431ea9e1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Number of all adverse drug reactions [&nbsp;Time&nbsp;Frame:&nbsp;after 12 and 26 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:3c72b206c2eea0bdbc6a10da431ea9e1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2e8e925bfba853bc1189ab608cf77c01' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>HbA1c [&nbsp;Time&nbsp;Frame:&nbsp;at 12 and 26 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:2e8e925bfba853bc1189ab608cf77c01' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f7e9bb498ae797e805d059960722fd0f' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Number of all hypoglycaemic events [&nbsp;Time&nbsp;Frame:&nbsp;in the 4 weeks preceding visit, at 12 weeks and the final visit at 26 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:f7e9bb498ae797e805d059960722fd0f' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c13ef0227cdc30e4ee366e0d87637701' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Variability in fasting plasma glucose (FPG) values and average FPG levels [&nbsp;Time&nbsp;Frame:&nbsp;at visits at 12 and 26 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:c13ef0227cdc30e4ee366e0d87637701' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ce6c16810684dc5f34821462fb3abaf7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Weight changes [&nbsp;Time&nbsp;Frame:&nbsp;at visits at 12 and 26 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:ce6c16810684dc5f34821462fb3abaf7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d2025e391c70af04ef33ede821db63c8' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This trial will be conducted in the United States of America (USA). The aim of this clinical trial is to investigate whether NNC 0070-0002-0349 is safe and well tolerated. Groups of eight subjects will be administered subcutaneous injections of NNC 0070-0002-0349 or placebo on Day 1 beginning with a low dose; after which laboratory and vital sign data as well as subject reported adverse events will be evaluated. If safe to proceed, the next group of subjects will be given a higher dose and the safety evaluation performed again before proceeding. In total, 5 dose levels will be evaluated. Subjects will be administered a dose and remain in the clinic until the morning of Day 8 after dosing and vital signs and safety labs as well as blood drawn for pharmacokinetic samples taken. Subjects will return to the clinic on Days 10, 12, 14, 16, 18 and 22 for repeat blood draws and safety labs. Day 22 is the final study visit.</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:d2025e391c70af04ef33ede821db63c8' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f33d5d3fe0baa6f58340b744ce4de442' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Single Subcutaneous Dose Rising Study to Investigate the Safety, Tolerability, Efficacy and Pharmacokinetics of NNC 0070-0002-0349 in Overweight/Obese Male Subjects</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:f33d5d3fe0baa6f58340b744ce4de442' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:748e1e24e033e880aa4f9b73c9930e67' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>BMI greater than 27.0 and less than 35.0 kg/m2</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Systolic blood pressure greater than 140 mm Hg or diastolic greater than 90 mm Hg</li>\n<li>Depression or suicidal thoughts (Scoring on Patient Health Questionnaire-9-item)</li>\n<li>Eating disorders</li>\n<li>Unusual diets or eating habits</li>\n<li>Dieting, use of diet drugs or obesity surgery</li>\n<li>Diabetes history or abnormal fasting glucose</li>\n</ul>\n</p>', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:748e1e24e033e880aa4f9b73c9930e67' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:00458b6a6cfde3cb1a027ed6c4a670ea' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>AUC (area under the curve) [&nbsp;Time&nbsp;Frame:&nbsp;21 days following dosing&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:00458b6a6cfde3cb1a027ed6c4a670ea' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bcec6d4da24d06c50b2138afe4e8ecfd' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Maximum plasma concentration [&nbsp;Time&nbsp;Frame:&nbsp;21 days following dosing&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:bcec6d4da24d06c50b2138afe4e8ecfd' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:40a4164ada87efcff590c5b8f9b13d07' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Time to maximum plasma concentration [&nbsp;Time&nbsp;Frame:&nbsp;21 days following dosing&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:40a4164ada87efcff590c5b8f9b13d07' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Half life [&nbsp;Time&nbsp;Frame:&nbsp;21 days following dosing&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:5a85d63aa4f63b6dc5b8d004b652b5d5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d10b5bde3211e5f16900175fe1aa5086' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This trial is conducted in Oceania. The aim of this trial is to compare the safety of using pulmonary inhaled human insulin to s.c. insulin aspart both combined with NPH insulin in subjects with type 1 diabetes.</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:d10b5bde3211e5f16900175fe1aa5086' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d80a637a2f8d6003ba642745b6d70eae' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Long Term Safety Trial Comparing Intensive Treatment of Pulmonary Inhaled Human Insulin With s.c. Insulin Aspart, Both in Combination With NPH, in Subjects With Type 1 Diabetes Mellitus</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:d80a637a2f8d6003ba642745b6d70eae' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4fccb17f8e5faf34f0e78c101c8a792b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Type 1 diabetes</li>\n<li>Current treatment with any insulin in any regimen</li>\n<li>Body mass index (BMI) below 38.0 kg/m2</li>\n<li>HbA1c below or equal to 13.0%</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Total daily insulin dosage more than 100 IU/day</li>\n<li>Current acute or chronic pulmonary disease (excluding asthma)</li>\n<li>Recurrent major hypoglycaemia</li>\n<li>Proliferative retinopathy or maculopathy requiring acute treatment</li>\n<li>Smoker</li>\n<li>Chest X-ray with clinically significant abnormalities</li>\n</ul>\n</p>', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:4fccb17f8e5faf34f0e78c101c8a792b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:38d8cff9a4f7007df4b9e9e667a2bb28' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Adverse events [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:38d8cff9a4f7007df4b9e9e667a2bb28' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Incidence of hypoglycaemic episodes [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:2668d9e59892d810a27a29eada34f860' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:758e76efcbe34fd00a1eee7bc75b6eec' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Glycaemic control as measured by HbA1c [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:758e76efcbe34fd00a1eee7bc75b6eec' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Long-term safety profiles (laboratory, ECG, insulin antibodies) [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:84733eefba6eed3366c65e98ed40d3d8' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:523253102e9358ac77ae1412fb6943b4' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Physical examination and body weight and vital signs [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:523253102e9358ac77ae1412fb6943b4' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:824f13f596e50d2aa2934cfc2e4d0b56' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Treatment satisfaction [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:824f13f596e50d2aa2934cfc2e4d0b56' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b38a64e1fa5716c3e4045f0a9c74660a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This trial is conducted in Europe. The aim of this clinical trial is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of a NNC126-0083 in healthy male Japanese subjects.</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:b38a64e1fa5716c3e4045f0a9c74660a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e693c20d3e6454ef091187739e0a7897' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Dose Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NCC126-0083 in Healthy Male Japanese Subjects.</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:e693c20d3e6454ef091187739e0a7897' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bf1af4023fa32dc7349736fcba8e8ff9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Healthy male subjects with Japanese passport and Japanese born parents</li>\n<li>Body Mass Index (BMI, kg/m2) between 18.0 and 27.0, both inclusive</li>\n<li>Subjects must be in good health according to age</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>A history or presence of cancer, diabetes, or any clinically significant cardiovascular, respiratory, metabolic, renal, hepatic, gastrointestinal, endocrinological, haematological, dermatological, venereal, neurological, psychiatric diseases or other major diseases</li>\n<li>History of any illnesses or disease that, in the opinion of the Investigator might confound the results of the trial or pose additional risk in administering the trial product to the subject</li>\n<li>Any clinically significant abnormal haematology, biochemistry or urinalysis screening tests, as judged by the Investigator</li>\n</ul>\n</p>', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:bf1af4023fa32dc7349736fcba8e8ff9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ee3bcd448df4d259aaecabd39df876ad' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>In this study we will determine the proper method for transitioning patients from a continuous insulin infusion to periodic injections of a newer long-acting insulin called detemir (Levemir).</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:ee3bcd448df4d259aaecabd39df876ad' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:da46b03f1fc15a7528bfca711738209a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Transitioning Post-Cardiothoracic Surgery Patients From Intravenous Insulin to the Subcutaneous Route With Insulin Detemir.</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:da46b03f1fc15a7528bfca711738209a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4b276acbd71b1426b1ef4edca28a2b07' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>High sugar (glucose) is common after surgery, even in patients who do not have diabetes. High glucose contributes to severe hospital complications and even death. Insulin infusions appear to reduce this risk, but are generally only continued for a few days after surgery. In this study, we will determine the proper method for transitioning patients from a continuous insulin infusion to periodic injections of a newer long-acting insulin called detemir (Levemir). 90 patients who have undergone recent open heart surgery and are requiring an insulin infusion will be enrolled. They will be randomly assigned to one of three doses of detemir, which consists of 50%, 65%, or 80% of the total daily insulin infusion requirement in the fasting state. Subjects will also receive identical mealtime coverage according to the amount of carbohydrate (glucose) that is ingested. It is expected that the high dose group will achieve superior glycemic control without excessive hypoglycemia.</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:4b276acbd71b1426b1ef4edca28a2b07' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:125975e606892246c1de6fec7c44a7d1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>diabetes mellitus</li>\n<li>post-cardiothoracic surgery</li>\n<li>requiring an insulin infusion of at least 1 unit/hour</li>\n<li>Age 18-75</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Glucocorticoids</li>\n<li>TPN or tube feeds</li>\n<li>Pregnancy</li>\n<li>Surgical procedures in the next 48 hours for whom IV insulin will be expected</li>\n<li>Expected length of stay less than 48 hours following cessation of the insulin drip</li>\n<li>Patients using subcutaneous insulin pumps</li>\n<li>Diabetic ketoacidosis</li>\n<li>End-stage renal disease</li>\n<li>End-stage liver disease</li>\n<li>Coma</li>\n<li>Potentially sensitive admissions: prisoners, HIV, suicidality</li>\n<li>Unable to give consent in English</li>\n</ul>\n</p>', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:125975e606892246c1de6fec7c44a7d1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b3c49aeaaae02128d264746d37316454' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage of patients with hypoglycemia (defined as glucose &lt;65 mg/dl [&nbsp;Time&nbsp;Frame:&nbsp;48 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:b3c49aeaaae02128d264746d37316454' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ff1bd2db5da95bc859dbeb8e0519d8c2' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Mean glucose at 6, 12, 24,48 hours [&nbsp;Time&nbsp;Frame:&nbsp;48 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:ff1bd2db5da95bc859dbeb8e0519d8c2' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:df0c394ca407d16ac0473d9a4aea3e68' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Reversion to intravenous insulin for failure of glycemic control [&nbsp;Time&nbsp;Frame:&nbsp;72 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:df0c394ca407d16ac0473d9a4aea3e68' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6984045672964125d2981d59f70e7b31' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Time required to reach AM glucose target of 80-130 mg/dl [&nbsp;Time&nbsp;Frame:&nbsp;72 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:6984045672964125d2981d59f70e7b31' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ed1e91175b8ae2a151b624fb27555bd3' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage of patients requiring an adjustment of greater than 15% in detemir dose at 24 or 48 hours [&nbsp;Time&nbsp;Frame:&nbsp;48 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:ed1e91175b8ae2a151b624fb27555bd3' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1e69895de8b419e38eb4f846db549160' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study is conducted in Asia. The aim of this observational study is to evaluate the incidence of major hypoglycaemic episodes and other adverse events, and to evaluate efficacy while using insulin under normal clinical practice conditions. The switch from OAD treatment to insulin therapy will be determined by physician.</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:1e69895de8b419e38eb4f846db549160' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:323ede110ec8ccc792a9080652de778d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Observational Safety and Efficacy Study in Subjects Using Insulin for the Treatment of Type 2 Diabetes Mellitus Failing on Oral Anti-Diabetic Agents</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:323ede110ec8ccc792a9080652de778d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:816b97f57d05187ef10c3eeb721f1db4' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Type 2 diabetes for at least 12 months and currently receiving oral anti-diabetic (OAD) treatment, whether single or combination, for at least 3 months before this study</li>\n<li>Insulin naive</li>\n<li>Poor glycaemic control on OADs and decided by the physician to start insulin therapy</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Type 1 diabetes patients</li>\n<li>Patients who are unlikely to comply with protocol, e.g., uncooperative attitude, inability to return for the final visit</li>\n<li>Patients with a hypersensitivity to insulin or to any of the excipients</li>\n<li>Patient groups not approved in the product label</li>\n</ul>\n</p>', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:816b97f57d05187ef10c3eeb721f1db4' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ebba7349c992d03ae70b128b1970686b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency and type of hypoglycaemic episodes [&nbsp;Time&nbsp;Frame:&nbsp;during 26 weeks of insulin therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:ebba7349c992d03ae70b128b1970686b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b13fad0897938c7df7c26bfe657aebd9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency and type of adverse events [&nbsp;Time&nbsp;Frame:&nbsp;during 26 weeks of insulin therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:b13fad0897938c7df7c26bfe657aebd9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e3e21ab4f16bbae87266e4c52633ebca' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency and type of adverse drug reactions [&nbsp;Time&nbsp;Frame:&nbsp;during 26 weeks of insulin therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:e3e21ab4f16bbae87266e4c52633ebca' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:940bbfbf16b0e69bc2ce596a05f1da03' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Change in HbA1c from baseline [&nbsp;Time&nbsp;Frame:&nbsp;during 26 weeks of insulin therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:940bbfbf16b0e69bc2ce596a05f1da03' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:69dd39658eab6ca6d6ffef671fbb3712' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Change in PPG from baseline [&nbsp;Time&nbsp;Frame:&nbsp;during 26 weeks of insulin therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:69dd39658eab6ca6d6ffef671fbb3712' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f9b27f015be6f597d7173218991f60cc' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Change in FPG from baseline [&nbsp;Time&nbsp;Frame:&nbsp;during 26 weeks of insulin therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:f9b27f015be6f597d7173218991f60cc' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6dc763395657b7bed11340d2841158a8' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Subjects\' insulin treatment satisfaction [&nbsp;Time&nbsp;Frame:&nbsp;during 26 weeks of insulin therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:6dc763395657b7bed11340d2841158a8' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1e89a2d74194f60792d6827666ac8c79' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Physicians\' satisfaction with insulin therapy [&nbsp;Time&nbsp;Frame:&nbsp;during 26 weeks of insulin therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:1e89a2d74194f60792d6827666ac8c79' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8fd99a28a88a24423d5d8810d2cac811' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Weight change [&nbsp;Time&nbsp;Frame:&nbsp;at the end of the study&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:8fd99a28a88a24423d5d8810d2cac811' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a994075b968914c5b6bf481c2fd27083' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage of patients reaching the target of HbA1c less than 7.5% [&nbsp;Time&nbsp;Frame:&nbsp;at the end of the study&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:a994075b968914c5b6bf481c2fd27083' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:04d5fd28226f4bb4e4d4d6b013fa33ee' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage of patients reaching the target of HbA1c less than 7% [&nbsp;Time&nbsp;Frame:&nbsp;at the end of the study&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:04d5fd28226f4bb4e4d4d6b013fa33ee' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fb3cf4f953f4ac7b18088061cd65da7b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage of patients reaching the target of HbA1c less than 6.5% [&nbsp;Time&nbsp;Frame:&nbsp;at the end of the study&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:fb3cf4f953f4ac7b18088061cd65da7b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:39e9abcf618909d1cde757abf66c691a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This trial is conducted in Europe. The aim of this clinical trial is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of NNC126-0083 in growth hormone deficient adults</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:39e9abcf618909d1cde757abf66c691a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fa4ef7fb23e7f4c5656a791203e634d4' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Dose Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC126-0083 in Growth Hormone Deficient Adults (GHDA)</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:fa4ef7fb23e7f4c5656a791203e634d4' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6f9ad8d0239383541c7759195045293c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>GHDA subjects as defined in the Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II</li>\n<li>Fertile females must agree to use appropriate contraceptive methods and have a negative pregnancy test at inclusion</li>\n<li>GH replacement therapy for more than 3 months</li>\n<li>Body Mass Index (BMI, kg/m2) of 22.0 to 35.0 kg/m2, both inclusive</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods</li>\n<li>Malignant disease</li>\n<li>Proliferative retinopathy judged by retina-photo within the last year - only with concomitant diabetes</li>\n<li>Heart insufficiency, NYHA class greater than 2</li>\n<li>Subjects with diabetes with an HbA1C above 8.0%</li>\n<li>Diabetic receiving insulin treatment</li>\n<li>Stable pituitary replacement therapy for less than 3 months</li>\n<li>Impaired liver function</li>\n<li>Impaired kidney function</li>\n</ul>\n</p>', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:6f9ad8d0239383541c7759195045293c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:744cfa13ed7c9d9b09c1a8cd073b38e1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study is conducted in Asia. The aim of this observational study is to evaluate safety, efficacy and convenience in using NovoMix&#174; 30 FlexPen&#174; in type 2 diabetes under normal clinical practice conditions.</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:744cfa13ed7c9d9b09c1a8cd073b38e1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9e542de42116548a972a15735cf6c7f3' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Observational, Safety and Efficacy Study in Subjects Using NovoMix&#174; 30 (Biphasic Insulin Aspart 30) FlexPen&#174; as Monotherapy or in Combination With OHA for the Treatment of Type 2 Diabetes Mellitus</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:9e542de42116548a972a15735cf6c7f3' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>All patients with type 2 diabetes, not adequately controlled on their current therapy, who were prescribed NovoMix&#174; 30 FlexPen&#174; as monotherapy, or in combination with OHA, in accordance with the approved labeling, are eligible for the survey.</li>\n</ul>\n</p>', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:e8d233ad7ab2a23860282fae85390d3d' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Change in HbA1c [&nbsp;Time&nbsp;Frame:&nbsp;after 12 weeks of therapy&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939935, expire = 1284026335, headers = '', serialized = 0 WHERE cid = '1:592a15c3c39d8d2831962b7a57a08a8c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:375cea8c0bee4abb169ffbb11809041b' in /persistent/html/includes/cache.inc on line 26.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Evaluation of general well-being by using the WHO-5 well-being questionnaire (Appendix I). [&nbsp;Time&nbsp;Frame:&nbsp;at 3 months and 6 months after baseline&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939936, expire = 1284026336, headers = '', serialized = 0 WHERE cid = '1:57367d95f8a6dbfcc9c62922b896b63a' in /persistent/html/includes/cache.inc on line 109.
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Observational Study to Observe the Safety of NovoMix® 30 Treatment in Patients With Type 2 Diabetes

Recruitment status: 
Recruiting

This study is conducted in Europe. The study aims to observe the incidence of serious adverse drug reactions in patients with type 2 diabetes during NovoMix® 30 treatment.

Background information
Trial ID: 
NCT00729898
Other unique IDs: 
BIASP-3512
Official title: 

Safety of NovoMix® 30 (Biphasic Insulin Aspart) Treatment in Patients With Type 2 Diabetes

Detailed description: 

 

Number to be enrolled: 
1800 patients

Examination of the Safety and Tolerability of NNC 0070-0002-0349 in Overweight/Obese Volunteers

Trial phase: 
Phase I
Recruitment status: 
Terminated

This trial will be conducted in the United States of America (USA). The aim of this clinical trial is to investigate whether NNC 0070-0002-0349 is safe and well tolerated. Groups of eight subjects will be administered subcutaneous injections of NNC 0070-0002-0349 or placebo on Day 1 beginning with a low dose; after which laboratory and vital sign data as well as subject reported adverse events will be evaluated. If safe to proceed, the next group of subjects will be given a higher dose and the safety evaluation performed again before proceeding. In total, 5 dose levels will be evaluated. Subjects will be administered a dose and remain in the clinic until the morning of Day 8 after dosing and vital signs and safety labs as well as blood drawn for pharmacokinetic samples taken. Subjects will return to the clinic on Days 10, 12, 14, 16, 18 and 22 for repeat blood draws and safety labs. Day 22 is the final study visit.

Background information
Trial ID: 
NCT00728455
Other unique IDs: 
NN9112-1905
Official title: 

Single Subcutaneous Dose Rising Study to Investigate the Safety, Tolerability, Efficacy and Pharmacokinetics of NNC 0070-0002-0349 in Overweight/Obese Male Subjects

Detailed description: 

 

Number to be enrolled: 
0 patients

Long Term Safety Trial to Compare Insulin Treatment With Preprandial Inhaled Human Insulin to s.c. Insulin Aspart Both Combined With NPH in Subjects With Type 1 Diabetes

Trial phase: 
Phase III
Recruitment status: 
Completed

This trial is conducted in Oceania. The aim of this trial is to compare the safety of using pulmonary inhaled human insulin to s.c. insulin aspart both combined with NPH insulin in subjects with type 1 diabetes.

Background information
Trial ID: 
NCT00725036
Other unique IDs: 
NN1998-1496
Official title: 

Long Term Safety Trial Comparing Intensive Treatment of Pulmonary Inhaled Human Insulin With s.c. Insulin Aspart, Both in Combination With NPH, in Subjects With Type 1 Diabetes Mellitus

Detailed description: 

 

Number to be enrolled: 
304 patients

Dose Study in Healthy Japanese Males Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083

Trial phase: 
Phase I
Recruitment status: 
Completed

This trial is conducted in Europe. The aim of this clinical trial is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of a NNC126-0083 in healthy male Japanese subjects.

Background information
Trial ID: 
NCT00722540
Other unique IDs: 
NN8630-1958
EudraCT No: 2008-001578-33
Official title: 

Dose Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NCC126-0083 in Healthy Male Japanese Subjects.

Detailed description: 

 

Number to be enrolled: 
40 patients
Acronym: 
EasyG

Transitioning Open Heart Surgery Patients From Insulin Infusions to Detemir

Trial phase: 
Phase 0
Recruitment status: 
Recruiting

In this study we will determine the proper method for transitioning patients from a continuous insulin infusion to periodic injections of a newer long-acting insulin called detemir (Levemir).

Background information
Trial ID: 
NCT00717288
Other unique IDs: 
2007H0210
60016576
Official title: 

Transitioning Post-Cardiothoracic Surgery Patients From Intravenous Insulin to the Subcutaneous Route With Insulin Detemir.

Detailed description: 

High sugar (glucose) is common after surgery, even in patients who do not have diabetes. High glucose contributes to severe hospital complications and even death. Insulin infusions appear to reduce this risk, but are generally only continued for a few days after surgery. In this study, we will determine the proper method for transitioning patients from a continuous insulin infusion to periodic injections of a newer long-acting insulin called detemir (Levemir). 90 patients who have undergone recent open heart surgery and are requiring an insulin infusion will be enrolled.

Number to be enrolled: 
90 patients

Observational Study to Evaluate Safety and Efficacy of Insulin Therapy in Type 2 Diabetes Mellitus Subjects Failing on Oral Anti-Diabetic Agents

Recruitment status: 
Active, not recruiting

This study is conducted in Asia. The aim of this observational study is to evaluate the incidence of major hypoglycaemic episodes and other adverse events, and to evaluate efficacy while using insulin under normal clinical practice conditions. The switch from OAD treatment to insulin therapy will be determined by physician.

Background information
Trial ID: 
NCT00715780
Other unique IDs: 
INS-3615
Official title: 

Observational Safety and Efficacy Study in Subjects Using Insulin for the Treatment of Type 2 Diabetes Mellitus Failing on Oral Anti-Diabetic Agents

Detailed description: 

 

Number to be enrolled: 
2000 patients

Dose Study in Growth Hormone Deficient Adults Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083

Trial phase: 
Phase II
Recruitment status: 
Completed

This trial is conducted in Europe. The aim of this clinical trial is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of NNC126-0083 in growth hormone deficient adults

Background information
Trial ID: 
NCT00715689
Other unique IDs: 
NN8630-1823
EudraCT No: 2008-001061-29
Official title: 

Dose Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC126-0083 in Growth Hormone Deficient Adults (GHDA)

Detailed description: 

 

Number to be enrolled: 
33 patients

Observational Study to Evaluate Safety, Efficacy and Convenience of Using NovoMix® 30 FlexPen® in Type 2 Diabetes

Recruitment status: 
Completed

This study is conducted in Asia. The aim of this observational study is to evaluate safety, efficacy and convenience in using NovoMix® 30 FlexPen® in type 2 diabetes under normal clinical practice conditions.

Background information
Trial ID: 
NCT00715663
Other unique IDs: 
NOPEN3-1891
Official title: 

Observational, Safety and Efficacy Study in Subjects Using NovoMix® 30 (Biphasic Insulin Aspart 30) FlexPen® as Monotherapy or in Combination With OHA for the Treatment of Type 2 Diabetes Mellitus

Detailed description: 

 

Number to be enrolled: 
1296 patients
Acronym: 
CEEP

Observational Study of Patients Using Levemir® or Insulatard® as Start Insulin for Treatment of Diabetes

Recruitment status: 
Completed

This trial is conducted in Europa. The aim of this observational study is to evaluate the glycaemic control, weight change and hypoglycaemic effects in patients with type 2 diabetes with Levemir® compared to Insulatard® under normal clinical practice conditions.

Background information
Trial ID: 
NCT00715351
Other unique IDs: 
NN304-1896
Official title: 

Efficacy and Safety of Glycaemic Control of Levemir® or Insulatard® in Patients With Type 2 Diabetes

Detailed description: 

 

Number to be enrolled: 
325 patients

Evaluation of Recombinant Factor XIII for Prevention of Bleeding in Patients With FXIII Inherited Deficiency

The trial is conducted in Asia, Europe and North America. The aim of this trial is to evaluate Recombinant FXIII treatment in patients with FXIII Inherited Deficiency. It is expected that Recombinant FXIII can be used as prevention of bleeding episodes

Background information
Other unique IDs: 
F13CD-1725
EudraCT No: 2006-003148-51
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