Novartis

  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4dc89c6f47e972ebb7a88fe11f685f07' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To evaluate safety, visual acuity outcomes, persistence of choroidal neovascular leakage, and the number of treatments of combination intravitreal bevacizumab and verteporfin photodynamic therapy at standard or reduced fluence level in patients with subfoveal CNV due to age-related macular degeneration.</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:4dc89c6f47e972ebb7a88fe11f685f07' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:01b72e64598ae14cf6cd13e6b90dc43c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Combination Bevacizumab and Verteporfin (Standard and Reduced Fluence)in the Treatment of Neovascular Age-Related Macular Degeneration</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:01b72e64598ae14cf6cd13e6b90dc43c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a05adb7f67206a0db1f780e179e6e4fe' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Patients are men or women of age 50 or older.</li>\n<li>Patients have not received previous treatment for subfoveal choroidal neovascularization (CNV).</li>\n<li>Patients must have evidence of active or recurrent subfoveal CNV as confirmed by fluorescein angiography.</li>\n<li>The total lesion must be less than or equal to 9 disc areas in size, with a greatest linear distance of 5400 microns.</li>\n<li>Best corrected visual acuity, using ETDRS charts, of 20/40 to 20/320 (Snellen equivalent) in the study eye. Only one eye will assessed in the study.</li>\n<li>The CNV lesion must be primarily CNV (i.e. CNV equal to or greater than 50% of the lesion.</li>\n<li>The CNV is associated with only macular degeneration.</li>\n<li>Patient defers other approved treatments of subfoveal CNV associated with AMD.</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Prior treatment for subfoveal choroidal neovascularization (CNV).</li>\n<li>Prior treatment for juxtafoveal or extrafoveal CNV involving previous antiangiogenic agent, photodynamic therapy, or intravitreal triamcinolone acetate.</li>\n<li>History of vitrectomy or submacular surgery in the study eye.</li>\n<li>Subretinal fibrosis accounting for more than 50% of the lesion.</li>\n<li>Non-CNV lesion components account for more than 50% of the total lesion components.</li>\n<li>CNV due to causes other than AMD.</li>\n<li>Retinal pigmented epithelial tear involving the center of the macula.</li>\n<li>Geographic atrophy involving the central macula.</li>\n<li>Any concurrent intraocular condition in the study eye that in the opinion of the investigator could require surgical or medical intervention during the course of the study (i.e. cataract).</li>\n<li>Active intraocular inflammation.</li>\n<li>Vitreous hemorrhage in the eye.</li>\n<li>History of spherical equivalent in the study eye greater than negative 8 diopters.</li>\n<li>Intraocular surgery within 2 months of study enrollment.</li>\n<li>Uncontrolled glaucoma in the study eye. Defined as intraocular pressure greater than 30mmHg despite treatment with anti-glaucoma medication.</li>\n<li>History of other disease, such as recent myocardial infarction, recent cerebral vascular accident, or uncontrolled hypertension that in the opinion of the investigator might render the subject at high risk for complication.</li>\n<li>Inability to comply with study or follow-up procedures.</li>\n</ul>\n</p>', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:a05adb7f67206a0db1f780e179e6e4fe' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:da4a5835464435411a6b276a474403ec' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Visual Acuity: Percentage of patients losing 3 or more lines(15 letters) of visual acuity from baseline. [&nbsp;Time&nbsp;Frame:&nbsp;1 Year&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:da4a5835464435411a6b276a474403ec' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7e4d9e2e71909738d50f0b58610e38f3' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Visual acuity: Percentage of patients gaining 3 or more lines(15 letters) of VA from baseline. [&nbsp;Time&nbsp;Frame:&nbsp;1 Year&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:7e4d9e2e71909738d50f0b58610e38f3' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9c2591b4623eb4482a4fa175bd2daeb8' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate safety, tolerability, pharmacokinetics and pharmacodynamics of albinterferon alfa 2b (alb-IFN) single dose in Japanese chronic hepatitis C patients</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:9c2591b4623eb4482a4fa175bd2daeb8' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4ed9bfa52ffbed626bb0fe969e507fc0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Escalating Single Dose of Albinterferon Alfa 2b (Alb-IFN), Recombinant Human Albumin-Interferon Alfa Fusion Protein in Japanese Chronic Hepatitis C Patients.</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:4ed9bfa52ffbed626bb0fe969e507fc0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:61795d6915e75cfb8c484511a0791247' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Have a clinical diagnosis of CHC established on the basis of a detectable viral load as measured by a serum HCV RNA test at least 6 months before and during the screening period.</li>\n<li>Age 20 to 69 years</li>\n<li>Have compensated liver disease results on screening laboratory assessment</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Evidence of decompensated liver disease and/or liver cirrhosis.</li>\n<li>Body weight &lt; 50 kg.</li>\n<li>A history of immunologically mediated disease.</li>\n<li>A history or other clinical evidence of interstitial lung disease</li>\n</ul>\n</p>', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:61795d6915e75cfb8c484511a0791247' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3dca513e0455dc16b8710608d508f07a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The proposed study is aimed to assess the safety and immunogenicity of rMenB when administered with or without routine infant vaccinations to healthy infants in their first year of life according to different immunization schedules. This study will also demonstrate that the immunogenicity of routine infant vaccines when given concomitantly with rMenB at 2, 3 and 4 months of age, is non-inferior to that of routine infant vaccines given without rMenB.</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:3dca513e0455dc16b8710608d508f07a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6f6404ce31fc559693463504070208a0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase 2b, Open Label, Randomized, Parallel-Group, Multi-Center Study to Evaluate the Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine When Administered With or Without Routine Infant Vaccinations to Healthy Infants</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:6f6404ce31fc559693463504070208a0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:177e09d3a97477ad10bb8ee00b3ae4ad' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Healthy 2-month old infants (55-89 days, inclusive), who were born after full term pregnancy with an estimated gestational age &#8805; 37 weeks and a birth weight &#8805; 2.5 kg;</li>\n<li>for whom a parent/legal guardian has given written informed consent after the nature of the study has been explained.</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>History of any meningococcal B or C vaccine administration;</li>\n<li>prior vaccination with routine infant vaccines (Diphtheria, Tetanus, Pertussis, Polio, Haemophilus influenzae type b (Hib), and Pneumococcal antigens);</li>\n<li>previous ascertained or suspected disease caused by N. meningitidis</li>\n<li>History of severe allergic reaction after previous vaccinations or hypersensitivity to any vaccine component;</li>\n<li>significant acute or chronic infection within the previous 7 days or axillary temperature major or equal to38 degrees within the previous day;</li>\n<li>antibiotics within 6 days prior to enrollment;</li>\n<li>any serious chronic or progressive disease</li>\n<li>known or suspected impairment or alteration of the immune system;</li>\n<li>receipt of blood, blood products and/or plasma derivatives or any parenteral immunoglobulin preparation.</li>\n</ul>\n</p>', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:177e09d3a97477ad10bb8ee00b3ae4ad' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:01c259f1a11cbe2c1c491915abb5e07c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This second extension will evaluate the efficacy and long term safety of zoledronic acid in women with post-menopausal osteoporosis</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:01c259f1a11cbe2c1c491915abb5e07c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ca85015669853586574c529f02f28177' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A 3-Year, Multicenter, Double-Blind, Randomized, Placebo-Controlled Extension to CZOL446H2301E1 to Evaluate the Efficacy and Long Term Safety of 6 and 9 Years Zoledronic Acid Treatment of Postmenopausal Women With Osteoporosis</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:ca85015669853586574c529f02f28177' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bb1b09a2a7f3613c9c456b0aa25b60f5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Women who have received the 4th and 6th dose of zoledronic acid in study CZOL446H2301E1</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Poor kidney, eye, liver health</li>\n<li>Use of certain therapies for osteoporosis in study CZOL446H2301E1</li>\n<li>Abnormal calcium levels</li>\n</ul>\n</p><p> Other protocol-defined inclusion/exclusion criteria may apply</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:bb1b09a2a7f3613c9c456b0aa25b60f5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:85e94902f3af12aab6690c7606c1ac39' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Differences between treatment groups in the percentage change of total hip and femoral neck BMD (bone mineral density) at year 7, 8 and 9 compared to year 0</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:85e94902f3af12aab6690c7606c1ac39' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ab4e324cc8db96711cc8d7008109c0f9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Differences between treatment groups in the percentage change of total hip BMD at year 7 and 8 compared to year 6</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:ab4e324cc8db96711cc8d7008109c0f9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:10c89237790a11069b56adbefb96d910' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Relative change in biomarkers</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:10c89237790a11069b56adbefb96d910' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:14d7b06584760ed279f4fa051c993a89' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Relative change in height</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:14d7b06584760ed279f4fa051c993a89' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f54689a99c5df549d8bff20cc9594466' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Differences between treatment groups in the number of clinical fractures</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:f54689a99c5df549d8bff20cc9594466' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:aafab867a18a3417cf2ec528c00ed2c1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate the safety, tolerability and efficacy of multiple doses of AFQ056 in patients with Fragile X Syndrome. The dose range will be 50 to 150 mg b.i.d. The primary read-out of efficacy is reduction in Aberrant-Behavior Checklist score.</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:aafab867a18a3417cf2ec528c00ed2c1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fee85171736f7170d6090ab244ca7ae5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Multi-Centre, Randomized, Double-Blind, Placebo Controlled, Two-Period, Crossover Proof-of-Concept Study in Male Patients With Fragile X Syndrome to Assess the Efficacy, Safety and Tolerability of Multiple Oral Doses of AFQ056</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:fee85171736f7170d6090ab244ca7ae5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e71e0c96966af47b84b7f5c2104d743c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Male, non-smoking patients between 18 and 35 years of age (both inclusive).</li>\n<li>Patients with fmr1 full mutation (&gt; 200 CGG repeats)</li>\n<li>Patients with a Clinical Global Impression Severity Score (CGI-S) of &gt; 4 (moderately ill)</li>\n<li>Patients with a score of &gt;20 in the ABC-C scale (at screening)</li>\n<li>Patients with a mental age of &#8805; 48 months as measured by the Stanford-Binet test</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Patients with DSM-IV diagnosis of schizophrenia, history and/or presence of psychosis, confusional states and/or repeated hallucinations.</li>\n<li>Patients with a history of seizures in the past 5 years without any therapeutic treatment controlling the disorders.</li>\n<li>Patients under stable anti-convulsant therapies that experienced seizures in the 2 years prior to randomization</li>\n<li>Patients with ECG abnormalities, autonomic dysfunctions, bronchospastic diseases, drug or atopic allergy</li>\n<li>Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism or excretion of drugs</li>\n<li>Patients using (or have used within four weeks before randomization) concomitant medications that are potent inhibitors of CYP3A4 (e.g., ketoconazole, ritonavir, etc.)</li>\n</ul>\n</p><p> Other protocol-defined inclusion/exclusion criteria may apply.</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:e71e0c96966af47b84b7f5c2104d743c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b9bb0ccba867a359c4999480cfa367c5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>28 days treatment with AFQ056 on behavior (communication, socialization, daily living, repetitive behaviors, anxiety/avoidance, clinical global improvement)</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:b9bb0ccba867a359c4999480cfa367c5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:034913eb44fa69518fbdcb582116a60c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>28 days treatment with AFQ056 on cognition (receptive language, attention, vigilance&#8230;)</p>\n', created = 1283572049, expire = 1283658449, headers = '', serialized = 0 WHERE cid = '1:034913eb44fa69518fbdcb582116a60c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3d5259dc35b185d110228995b5114345' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate the safety and tolerability of nilotinib after failure of imatinib therapy or imatinib therapy after nilotinib failure.</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:3d5259dc35b185d110228995b5114345' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Extension Study to a Phase III Multi-Center, Open-Label, Randomized Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosomepositive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:f3e1700fba409ff826737e4811f69bef' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4c7908df7d5cc9871b426e1f9573a1b7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion criteria\n<ol>\n<li>Male or female patients &#8805; 18 years of age.</li>\n<li>ECOG 0, 1, or 2.</li>\n<li>Patients with Ph+ CML who have failed treatment in the core protocol.</li>\n<li>Diagnosis of chronic myelogenous leukemia with cytogenetic confirmation of Philadelphia chromosome of (9;22) translocations (presence of BCR-ABL a review of a minimum 20 metaphases is required).</li>\n<li>Adequate end organ function as defined by:\n<ul>\n<li>Total bilirubin &lt; 1.5 x ULN,</li>\n<li>SGOT and SGPT &lt; 2.5 x ULN,</li>\n<li>Creatinine &lt; 1.5 x ULN,</li>\n<li>Serum amylase and lipase &#8804; 1.5 x ULN,</li>\n<li>Alkaline phosphatase &#8804; 2.5 x ULN unless considered tumor related.</li>\n</ul>\n</li>\n<li>Patients must have the following laboratory values (&#8805; LLN (lower limit of normal) or corrected to within normal limits with supplements prior to the first dose of study medication.):\n<ul>\n<li>Potassium &#8805; LLN,</li>\n<li>Magnesium &#8805; LLN,</li>\n<li>Phosphorus &#8805; LLN,</li>\n<li>Total calcium (corrected for serum albumin) &#8805; LLN.</li>\n</ul>\n</li>\n</ol>\n</p><p> Exclusion criteria\n<ol>\n<li>Previously documented T315I mutations.</li>\n<li>Impaired cardiac function including any one of the following:\n<ul>\n<li>LVEF &lt; 45% or below the institutional lower limit of the normal range (whichever is higher) as determined by locally read echocardiogram.</li>\n<li>Inability to determine the QT interval on ECG.</li>\n<li>Complete left bundle branch block.</li>\n<li>Use of a ventricular-paced pacemaker.</li>\n<li>Congenital long QT syndrome or a known family history of long QT syndrome.</li>\n<li>History of or presence of clinically significant ventricular or atrial tachyarrhythmias.</li>\n</ul>\n</li>\n</ol>\n</p>', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:4c7908df7d5cc9871b426e1f9573a1b7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:11e7451c2cb9a078048cf1dc3a55e178' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Treatment with MMF often results in adverse GI events, which can lead to dose reductions of MMF and decreased graft function. Enteric-coated mycophenolate sodium (MYFORTIC*) was developed as an alternative formulation of MPA to improve upper GI tract side effects. An improvement in the severity of GI side effects could result in an increased tolerance to MPA and an improvement in patient quality of life. This study will use the GSRS to evaluate improvement in gastrointestinal symptoms.</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:11e7451c2cb9a078048cf1dc3a55e178' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3ede948f38658a0437591c0dd7482c0d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Prospective, 6 Month, Open Label, Conversion Study From MMF to PRMYFORTIC* Evaluating the Severity of GI Symptoms and MPA Metabolite as a Surrogate Marker of MYFORTIC</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:3ede948f38658a0437591c0dd7482c0d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6ccfaef74609554264e73583a6cb0af9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate the change in the total gastrointestinal symptom rating scale (GSRS) score at baseline versus month 1,at baseline versus month 3 and at baseline versus month 6 after conversion from MMF to PRMYFORTIC* .</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:6ccfaef74609554264e73583a6cb0af9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d4c506a42100101b10c073d6f5337528' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Received a kidney transplant at least six months</li>\n<li>stable graft function (no increased creatinine &gt; 20% in the previous 4 weeks)</li>\n<li>Receiving immunosuppressive regimen with stable dose of MMF for at least 4 weeks</li>\n<li>Immunosuppressive regimen with a dose of MMF (dose&#8804; 2.0 g/day) at least 4 weeks OR C0 MMF &lt; 1.4 &#181;g/ml at visit 1 OR patients receiving MMF who have GI side effects</li>\n<li>Willing to provide written informed consent</li>\n<li>Women of childbearing age must have a negative pregnancy test and use a medically acceptable method of contraception throughout the treatment period;</li>\n<li>Over 18 years of age.</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>GI symptoms assumed or known not to be caused by MPA therapy;</li>\n<li>Acute rejection episode &#8804; 4 weeks prior to study enrollment;</li>\n<li>Liver disease interfering with enterohepatic recirculation, such as active hepatitis B, active hepatitis C, autoimmune hepatitis and liver cirrhosis;</li>\n<li>Female patients who are pregnant, lactating or of child bearing potential and not practicing an approved method of birth control;</li>\n<li>Active bacterial, viral or fungal infection;</li>\n<li>Presence of psychiatric illness that in the view of the investigator would interfere with study requirements;</li>\n<li>Known sensitivity to the study drug;</li>\n<li>Receiving any investigational drug or have received any investigational drug within 30 days prior to study enrollment.</li>\n</ul>\n</p>', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:d4c506a42100101b10c073d6f5337528' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to determine whether the combination of Myfortic and sirolimus is effective at preventing rejection while preserving kidney function in stable kidney transplant recipients.</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:a7eb114c29aef847091f20d3402eb0be' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:839a0eef53bb39e760e687efb710b8b4' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this research is to establish if a once a year dose of Zoledronic Acid is sufficient to suppress and maintain urine bone density markers (NTx) within normal range at 12 months post-dosing in postmenopausal early breast cancer patients receiving additional treatment with non-steroidal aromatase inhibitors.</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:839a0eef53bb39e760e687efb710b8b4' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d20ac383f99e052a714809c300e97ff7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate the pharmacodynamics and pharmacokinetics of darifenacin liquid oral suspension in children, ages 6-15 years, with neurogenic detrusor overactivity. The results will support a benefit-risk based dosage recommendation for phase IIIa clinical trials.</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:d20ac383f99e052a714809c300e97ff7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0d9bd976860196d0f42b90f0b30cfb9e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A 14-Day, Open-Label, Multicenter, Dose-Escalating, Sequential Cohort Study to Evaluate Pharmacodynamics (Urodynamics) and Pharmacokinetics, Clinical Efficacy, Tolerability and Safety, Following Multiple Doses (mg/kg/Day) of a Darifenacin Liquid Oral Susp</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:0d9bd976860196d0f42b90f0b30cfb9e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8ca1be60d0f2a1fcca5df30d34adaea5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Male and female patients ages 6-15 years</li>\n<li>Documented detrusor overactivity associated with a known neurological condition such as meningomyelocele, and confirmed by urodynamics at baseline</li>\n<li>Using clean intermittent catheterization (CIC) on a regular basis</li>\n<li>Participating in a bowel program on a regular basis</li>\n<li>Able to swallow the study medication in accordance to the protocol</li>\n<li>Patients and/or parent/guardian able to complete the bladder diary and follow the study procedures</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Treatment with drugs known to significantly affect the urinary bladder and urinary bladder outlet function</li>\n<li>Fecal impaction. Patients may be included, once this condition has resolved</li>\n<li>Clinically significant anatomical abnormalities or acquired disorders of the urinary tract</li>\n<li>Previous reconstructive surgery (augmentation etc.) of the bladder or bladder outlet</li>\n<li>Symptomatic urinary tract infection unresolved at time of urodynamic study and/or completion of bladder diary.</li>\n<li>Diabetes insipidus</li>\n<li>Electro stimulation therapy or bladder training within 2 weeks prior to Visit 1 and at any time during the study</li>\n<li>Concomitant diseases, in which the use of darifenacin is contraindicated</li>\n<li>History of hypersensitivity to darifenacin or to drugs with similar chemical structures</li>\n<li>Patients with any physical and cognitive impairment or any other condition which in the opinion of the investigator makes the patient unsuitable for inclusion</li>\n<li>Female adolescent of child-bearing potential, unless using an acceptable method of contraception</li>\n<li>Pregnant or nursing (lactating) female adolescents Other protocol-defined inclusion/exclusion criteria may apply.</li>\n</ul>\n</p>', created = 1283572050, expire = 1283658450, headers = '', serialized = 0 WHERE cid = '1:8ca1be60d0f2a1fcca5df30d34adaea5' in /persistent/html/includes/cache.inc on line 109.

Bevacizumab in Combination With Visudyne Photodynamic Therapy (PDT)

Trial phase: 
Phase II
Recruitment status: 
Active, not recruiting

To evaluate safety, visual acuity outcomes, persistence of choroidal neovascular leakage, and the number of treatments of combination intravitreal bevacizumab and verteporfin photodynamic therapy at standard or reduced fluence level in patients with subfoveal CNV due to age-related macular degeneration.

Background information
Trial ID: 
NCT00729846
Other unique IDs: 
BPDT2006
Official title: 

Combination Bevacizumab and Verteporfin (Standard and Reduced Fluence)in the Treatment of Neovascular Age-Related Macular Degeneration

Detailed description: 

 

Number to be enrolled: 
22 patients

Albinterferon Alfa 2b Single Dose in Japanese Chronic Hepatitis C Patients

Trial phase: 
Phase I
Recruitment status: 
Recruiting

This study will evaluate safety, tolerability, pharmacokinetics and pharmacodynamics of albinterferon alfa 2b (alb-IFN) single dose in Japanese chronic hepatitis C patients

Background information
Trial ID: 
NCT00724776
Other unique IDs: 
CABF656A1202
Official title: 

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Escalating Single Dose of Albinterferon Alfa 2b (Alb-IFN), Recombinant Human Albumin-Interferon Alfa Fusion Protein in Japanese Chronic Hepatitis C Patients.

Detailed description: 

 

Number to be enrolled: 
30 patients

Safety, Tolerability and Immunogenicity of Meningococcal B Recombinant Vaccine Administered With or Without Routine Infant Vaccinations to Healthy Infants According to Different Immunization Schedules

Trial phase: 
Phase III
Recruitment status: 
Recruiting

The proposed study is aimed to assess the safety and immunogenicity of rMenB when administered with or without routine infant vaccinations to healthy infants in their first year of life according to different immunization schedules. This study will also demonstrate that the immunogenicity of routine infant vaccines when given concomitantly with rMenB at 2, 3 and 4 months of age, is non-inferior to that of routine infant vaccines given without rMenB.

Background information
Trial ID: 
NCT00721396
Other unique IDs: 
V72P12
Official title: 

A Phase 2b, Open Label, Randomized, Parallel-Group, Multi-Center Study to Evaluate the Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine When Administered With or Without Routine Infant Vaccinations to Healthy Infants

Detailed description: 

 

Number to be enrolled: 
1800 patients

3-Year Efficacy and Safety Study of Zoledronic Acid in Post-Menopausal Women With Osteoporosis Treated With Zoledronic Acid for 6 Years

Trial phase: 
Phase III
Recruitment status: 
Enrolling by invitation

This second extension will evaluate the efficacy and long term safety of zoledronic acid in women with post-menopausal osteoporosis

Background information
Trial ID: 
NCT00718861
Other unique IDs: 
CZOL446H2301E2
Official title: 

A 3-Year, Multicenter, Double-Blind, Randomized, Placebo-Controlled Extension to CZOL446H2301E1 to Evaluate the Efficacy and Long Term Safety of 6 and 9 Years Zoledronic Acid Treatment of Postmenopausal Women With Osteoporosis

Detailed description: 

 

Number to be enrolled: 
400 patients

Efficacy, Safety and Tolerability of AFQ056 in Fragile X Patients

Trial phase: 
Phase II
Recruitment status: 
Enrolling by invitation

This study will evaluate the safety, tolerability and efficacy of multiple doses of AFQ056 in patients with Fragile X Syndrome. The dose range will be 50 to 150 mg b.i.d. The primary read-out of efficacy is reduction in Aberrant-Behavior Checklist score.

Background information
Trial ID: 
NCT00718341
Other unique IDs: 
CAFQ056A2204
Official title: 

A Multi-Centre, Randomized, Double-Blind, Placebo Controlled, Two-Period, Crossover Proof-of-Concept Study in Male Patients With Fragile X Syndrome to Assess the Efficacy, Safety and Tolerability of Multiple Oral Doses of AFQ056

Detailed description: 

 

Number to be enrolled: 
30 patients

Efficacy and Safety of Nilotinib Patients With Newly Diagnosed CML - CP (Chronic Myelogenous Leukemia - Chronic Phase)

Trial phase: 
Phase III
Recruitment status: 
Active, not recruiting

This study will evaluate the safety and tolerability of nilotinib after failure of imatinib therapy or imatinib therapy after nilotinib failure.

Background information
Trial ID: 
NCT00718263
Other unique IDs: 
CAMN107A2303E1
Official title: 

Extension Study to a Phase III Multi-Center, Open-Label, Randomized Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosomepositive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)

Detailed description: 

 

Number to be enrolled: 
90 patients

Prospective, 6 Month, Open Label, Conversion Study From Mycophenolate Mofetil (MMF) to PRMYFORTIC*

Recruitment status: 
Recruiting

Treatment with MMF often results in adverse GI events, which can lead to dose reductions of MMF and decreased graft function. Enteric-coated mycophenolate sodium (MYFORTIC*) was developed as an alternative formulation of MPA to improve upper GI tract side effects. An improvement in the severity of GI side effects could result in an increased tolerance to MPA and an improvement in patient quality of life. This study will use the GSRS to evaluate improvement in gastrointestinal symptoms.

Background information
Trial ID: 
NCT00715468
Other unique IDs: 
CERL080ACA07
Official title: 

Prospective, 6 Month, Open Label, Conversion Study From MMF to PRMYFORTIC* Evaluating the Severity of GI Symptoms and MPA Metabolite as a Surrogate Marker of MYFORTIC

Detailed description: 

This study will evaluate the change in the total gastrointestinal symptom rating scale (GSRS) score at baseline versus month 1,at baseline versus month 3 and at baseline versus month 6 after conversion from MMF to PRMYFORTIC* .

Number to be enrolled: 
65 patients

Study Evaluating Conversion From Tacrolimus to Sirolimus in Stable Kidney Transplant Recipients Receiving Myfortic

The purpose of this study is to determine whether the combination of Myfortic and sirolimus is effective at preventing rejection while preserving kidney function in stable kidney transplant recipients.

Background information
Other unique IDs: 
KTXP_US28_MYFIIRP07

Single Dosing of Zoledronic Acid in Cancer Therapy Induced Bone Loss (CTIBL)

The purpose of this research is to establish if a once a year dose of Zoledronic Acid is sufficient to suppress and maintain urine bone density markers (NTx) within normal range at 12 months post-dosing in postmenopausal early breast cancer patients receiving additional treatment with non-steroidal aromatase inhibitors.

Background information
Other unique IDs: 
CZOL446H US113

2 Week Open-Label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (6 - 15 Yrs) With Neurogenic Detrusor Overactivity

Trial phase: 
Phase II
Recruitment status: 
Recruiting

This study will evaluate the pharmacodynamics and pharmacokinetics of darifenacin liquid oral suspension in children, ages 6-15 years, with neurogenic detrusor overactivity. The results will support a benefit-risk based dosage recommendation for phase IIIa clinical trials.

Background information
Trial ID: 
NCT00712322
Other unique IDs: 
CDAR328B2201
Official title: 

A 14-Day, Open-Label, Multicenter, Dose-Escalating, Sequential Cohort Study to Evaluate Pharmacodynamics (Urodynamics) and Pharmacokinetics, Clinical Efficacy, Tolerability and Safety, Following Multiple Doses (mg/kg/Day) of a Darifenacin Liquid Oral Susp

Detailed description: 

 

Number to be enrolled: 
60 patients
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