National Institute of Mental Health (NIMH)

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Family Centered Advanced Care Planning for Adolescents With HIV/AIDS and Their Families

This study will examine the efficacy of Family Centered Advance Care Planning in enhancing quality of life, integrating effective end-of-life care, and preventing depression and anxiety among HIV infected adolescents and their family members.

Background information
Other unique IDs: 
DAHBR 9A-ASPA
R34 MH072541

Effectiveness of Anger Management Treatment in Reducing Anger-Related Behaviors in Female Juvenile Offenders

This study will evaluate the effectiveness of an anger management treatment program, Juvenile Justice Anger Management for Girls, in reducing anger-related behaviors displayed by girls in the juvenile justice system.

Background information
Other unique IDs: 
DSIR 82-SEMS
K23 MH070400

Identifying Predictors of Bipolar Disorder Relapse During Pregnancy and the Postpartum Period

This study will evaluate pregnant women who have bipolar disorder to gain a better understanding of risk factors for bipolar disorder relapse during pregnancy and the postpartum period.

Background information
Other unique IDs: 
R01 MH085026
DATR A2-AIE

Effectiveness of a Technology Assisted Behavioral Intervention in Assisting People With Major Depressive Disorder

Trial phase: 
Phase I
Recruitment status: 
Not yet recruiting

This study will develop and evaluate the effectiveness of a technology-assisted behavioral intervention, consisting of Internet-based cognitive behavioral therapy combined with telephone and email support, in reducing depressive symptoms and improving treatment adherence in primary care patients with major depressive disorder.

Background information
Trial ID: 
NCT00719979
Other unique IDs: 
DSIR 83-ATP
R34 MH078922
Official title: 

Integrated Telemental Health Intervention for Depression in Primary Care

Detailed description: 

Major depressive disorder (MDD) is a common mental disorder, with up to 10.3% of the population experiencing the disorder in a given 12-month period. Symptoms of MDD include feelings of anxiety, guilt, or hopelessness; irregular sleep and appetite patterns; lethargy; excessive irritability and restlessness; inability to concentrate; and lack of enjoyment in previously enjoyed activities. Fortunately, MDD is treatable with forms of psychotherapy and/or antidepressant medications.

Number to be enrolled: 
70 patients

Effectiveness of an Extended Release Stimulant Medication in Treating Preschool Children With Attention Deficit Hyperactivity Disorder (The APS Study)

Recruitment status: 
Recruiting

This study will evaluate the safety and effectiveness of extended release mixed amphetamine salts in treating preschool children with attention deficit hyperactivity disorder.

Background information
Trial ID: 
NCT00712699
Other unique IDs: 
F32 MH078388
DDTR BK-TKFND
Official title: 

Placebo vs. Extended Release Stimulant Crossover Trial in Preschoolers With ADHD

Detailed description: 

Attention deficit hyperactivity disorder (ADHD) is a common developmental disorder that affects between 4% and 12% of school-aged children. Children with ADHD often show symptoms of hyperactivity, inattention, inability to sit still, trouble listening, excessive talking, and aggression. ADHD is generally not diagnosed and treated in children less than 6 years old because some symptoms of ADHD are difficult to distinguish from normal behaviors of preschool-aged children.

Number to be enrolled: 
30 patients

Psychosocial Needs of YMSM

The proposed study will use both qualitative and quantitative research methods (mixed methods) to gather data that will support the eventual development of interventions for young men who have sex with men (YMSM) living with behaviorally acquired HIV infection. The overall goal of the study is to gain an understanding of the psychosocial/developmental needs of YMSM by focusing on two critical developmental issues—identity development and future life goals.

Background information
Other unique IDs: 
ATN 070

Effectiveness of a Community-Level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-Risk Populations

Trial phase: 
Phase III
Recruitment status: 
Completed

This study will evaluate the effectiveness of a community-level HIV prevention program in promoting safer sexual behaviors and reducing the transmission of HIV/sexually transmitted diseases among at-risk populations in China, India, Peru, Russia, and Zimbabwe.

Background information
Trial ID: 
NCT00710060
Other unique IDs: 
U10 MH61537
U10MH061499
U10MH061513
U10MH061536
U10MH061543
U10MH061544
DAHBR 9A-ASGT
Official title: 

NIMH Collaborative HIV/STD Prevention Trial

Detailed description: 

The HIV/AIDS epidemic remains largely out of control in many areas of the world, with an estimated 2.5 million new HIV infections worldwide in 2007. Developing countries with few economic resources and world regions undergoing difficult social transitions have been particularly impacted by large increases in HIV and sexually transmitted disease (STD) infections. To date, effective individual prevention approaches have not been rapid enough to avert the epidemic in these areas and may be too resource intensive to maintain.

Number to be enrolled: 
18147 patients

Effectiveness of a Cognitive Behavioral Treatment for Reducing Atypical Antipsychotic Medication Health Risks in People With Serious Mental Illness

Trial phase: 
Phase I
Recruitment status: 
Enrolling by invitation

This study will evaluate the effectiveness of a cognitive behavioral treatment in reducing significant medical risk factors often associated with people who have a serious mental illness and are taking atypical antipsychotic medications.

Background information
Trial ID: 
NCT00709345
Other unique IDs: 
DAHBR 96-BHB
R01 MH078576
Official title: 

Behavioral Intervention to Reduce Novel Antipsychotic Medication Health Risks

Detailed description: 

Serious mental illness encompasses a large range of symptoms varying in severity, but generally includes symptoms described as both positive and negative. Positive symptoms include confused thinking, delusions, and hallucinations, while negative symptoms include lack of emotion and depression. Because novel or atypical antipsychotic medications target both positive and negative symptoms and have fewer side effects than other medications, they make up the current standard of care for the treatment of many mental illnesses.

Number to be enrolled: 
333 patients

Effectiveness of Collaborative Depression Care Management in Treating Depressed Low-Income Hispanics With Diabetes

This study will evaluate the effectiveness of culturally adapted depression treatment for reducing depressive symptoms and improving adherence to diabetes self-care regimens in Hispanics with depression and diabetes.

Background information
Other unique IDs: 
R01 MH068468
DSIR 82-SESQ

PharmacofMRI of Anxiolytic Medications (Pregabalin)

The purpose of this study is to use functional magnetic resonance imaging (fMRI) in healthy controls to examine the acute effects of certain anxiolytic medications on brain function. In this case, the medication pregabalin will be used. The investigators hypothesize that pregabalin (at doses of 50 mg and 200 mg, versus placebo) will yield a reduction in amygdala and insula activity (in a dose-dependent fashion) during emotion processing using fMRI.

Background information
Other unique IDs: 
UCSD IRB 060407 - B
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