National Institute of Mental Health (NIMH)

  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f297ea217f9bba61bb68baeb1912e015' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will examine the efficacy of Family Centered Advance Care Planning in enhancing quality of life, integrating effective end-of-life care, and preventing depression and anxiety among HIV infected adolescents and their family members.</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:f297ea217f9bba61bb68baeb1912e015' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate the effectiveness of an anger management treatment program, Juvenile Justice Anger Management for Girls, in reducing anger-related behaviors displayed by girls in the juvenile justice system.</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:34c3d788dc0a64e307b15b187f731809' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate pregnant women who have bipolar disorder to gain a better understanding of risk factors for bipolar disorder relapse during pregnancy and the postpartum period.</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:9a9bd65b3d893cdcae25a09744aa15a8' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will develop and evaluate the effectiveness of a technology-assisted behavioral intervention, consisting of Internet-based cognitive behavioral therapy combined with telephone and email support, in reducing depressive symptoms and improving treatment adherence in primary care patients with major depressive disorder.</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:6cbe310dbec979db35b3c534b1bc6515' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0186b91b76b1df1b2d1ec9a1a5449ef5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Integrated Telemental Health Intervention for Depression in Primary Care</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:0186b91b76b1df1b2d1ec9a1a5449ef5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6ba50b4f329e8abe10251e53a810d912' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Major depressive disorder (MDD) is a common mental disorder, with up to 10.3% of the population experiencing the disorder in a given 12-month period. Symptoms of MDD include feelings of anxiety, guilt, or hopelessness; irregular sleep and appetite patterns; lethargy; excessive irritability and restlessness; inability to concentrate; and lack of enjoyment in previously enjoyed activities. Fortunately, MDD is treatable with forms of psychotherapy and/or antidepressant medications. Several studies have found that when given a choice, about two-thirds of depressed patients prefer psychotherapy treatment over antidepressant medication. Although psychotherapy treatments are both effective and desirable, a variety of barriers exist to initiating and sustaining psychotherapy. Only about 20% of all patients referred for psychotherapy treatments ever follow up. Of those who do initiate psychotherapy, nearly half drop out before completing treatment. Delivering an intervention through telecommunication technologies, such as the telephone and Internet, has the potential to overcome many of the barriers to existing treatments for depression. For example, telephone- and Web-based interventions can reduce cost, extend specialized treatment over broad geographic areas, and permit considerable flexibility in scheduling of treatment components. Technology-assisted Behavioral Intervention(TABI) is a specific form of a telecommunication behavioral intervention that incorporates Web-based Internet, e-mail, and telephone intervention. Further study is needed to determine the effectiveness of TABI in reducing depressive symptoms and attrition rates in people with MDD. This pilot study will first develop TABI, which will consist of Internet-based cognitive behavioral therapy (I-CBT) accompanied by telephone and e-mail support. The study will then compare the effectiveness of TABI with the effectiveness of I-CBT alone and treatment as usual (TAU) in reducing depressive symptoms and improving treatment adherence in primary care patients with MDD. Participation in the treatment phase of this study will last 16 weeks. All participants will first undergo initial assessments that will include a telephone interview and a series of questionnaires about mood. Eligible participants will then be assigned randomly to receive TABI, I-CBT alone, or TAU. Participants assigned to TABI and I-CBT will both undergo 16 weeks of a Web-based Internet intervention consisting of modules to help them learn skills to manage their moods. Participants will be asked to access the Web site every day or two to complete the modules and to practice the learned techniques. Participants assigned to TABI will also receive a weekly telephone-based motivational intervention from a coach and will be able to communicate with the coach via email throughout the first 12 weeks of treatment. The last 4 weeks of treatment will be completed without assistance from the coach. Participants assigned to TAU will receive standard treatment from their primary care physicians and will be able to choose between TABI and I-CBT treatment options after a 16-week wait-list period. All participants will undergo repeat initial assessments at Weeks 6, 12, and 16 of treatment.</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:6ba50b4f329e8abe10251e53a810d912' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bb90cd50b516d30a4e159f11162aacf8' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>DSM-IV diagnosis of MDD as assessed using the Mini Mental State Exam (MINI) plus a score of 16 or greater on the HRSD</li>\n<li>Has a telephone, email account, computer, and broadband access to the Internet</li>\n<li>Able to navigate the Internet</li>\n<li>Able to speak and read English</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Hearing or voice impairment</li>\n<li>Visual impairment that would prevent use of the workbook and completion of assessment materials</li>\n<li>Meets criteria for dementia</li>\n<li>Diagnosed with a psychotic disorder, bipolar disorder, dissociative disorder, current substance abuse, or other diagnosis for which participation in a clinical trial of psychotherapy may be either inappropriate or dangerous</li>\n<li>Currently receiving individual psychotherapy or planning to receive psychotherapy during the 12-week treatment phase of the study</li>\n<li>Planning to be out of town or unavailable for treatment for 4 weeks or more during the scheduled treatment time</li>\n<li>Exhibits severe suicidality, including ideation, plan, and intent</li>\n</ul>\n</p>', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:bb90cd50b516d30a4e159f11162aacf8' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1cb036c219a980b5b7803fe8052b09a7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate the safety and effectiveness of extended release mixed amphetamine salts in treating preschool children with attention deficit hyperactivity disorder.</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:1cb036c219a980b5b7803fe8052b09a7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8544bcc3904ecd9edf31992fe12f2e49' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Placebo vs. Extended Release Stimulant Crossover Trial in Preschoolers With ADHD</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:8544bcc3904ecd9edf31992fe12f2e49' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:97ea51e282c9eb59865aa11618b5306d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Attention deficit hyperactivity disorder (ADHD) is a common developmental disorder that affects between 4% and 12% of school-aged children. Children with ADHD often show symptoms of hyperactivity, inattention, inability to sit still, trouble listening, excessive talking, and aggression. ADHD is generally not diagnosed and treated in children less than 6 years old because some symptoms of ADHD are difficult to distinguish from normal behaviors of preschool-aged children. However, some preschool children who exhibit symptoms indicative of ADHD and who have been carefully diagnosed by a health professional may benefit from early treatment to lower risk for functional impairment later in childhood. Currently, environmental changes, parent effectiveness training, and behavior therapy are the commonly used treatments for preschoolers with ADHD symptoms, but not all preschoolers respond well to such behavioral interventions. These children may benefit from medication treatment; however, the safety and effectiveness of ADHD medications in treating preschool-aged children is not well known. Extended release mixed amphetamine salts (XR-MAS), a stimulant medication, is a commonly prescribed and approved medication for treating ADHD in children 6 years and older. Further study is needed to determine how XR-MAS affects preschool-aged children with ADHD symptoms. This study will compare the safety and effectiveness of XR-MAS versus placebo in treating preschool children with ADHD. Participation in this study will last 6 weeks. All participants will first undergo rigorous psychiatric assessments to confirm their diagnosis of ADHD. Eligible participants will then be assigned randomly to receive treatment with either XR-MAS then placebo or placebo then XR-MAS. Participants will take their assigned XR-MAS or placebo medications for 3 weeks and then cross over to the other medication for an additional 3 weeks of treatment. Rating scale scores will be collected weekly from parents and teachers to assess symptom response and measures of safety.</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:97ea51e282c9eb59865aa11618b5306d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a97f9ee764fd58ba2f27e28eaa04fbc5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Living at home for at least 6 months with parent or caregiver</li>\n<li>Enrolled in a structured school setting at least 2 half days a week with a minimum of 7 peers</li>\n<li>Full Scale Intelligence Quotient (FSIQ) of 70 or greater OR 72 or greater if bilingual</li>\n<li>Best estimate diagnosis based on clinical interview, Diagnostic Interview Schedule for Children, Child Behavior Checklist, and rating scales scores</li>\n<li>Symptoms present for at least 9 months</li>\n<li>Meets severity criteria for Clinical Global Impression-Severity with score of greater than or equal to 4 and Clinical Global Assessment Scale score of greater than or equal to 55</li>\n<li>Parent/caregiver can commit to 6 weekly sessions, including initial screening exams</li>\n<li>If on current psychotropic medication, will undergo a washout period of at least 3 days before study entry</li>\n<li>Not currently receiving psychotherapy or started psychotherapy within 30 days of study entry</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Previous nonresponse to mixed amphetamine salts (defined as 2 weeks of persistent symptoms in spite of doses greater than or equal to 15 mg per day)</li>\n<li>Diagnosis of language-based or cognitive delay of more than 2 standard deviations below same-aged peers or diagnosis of mental retardation</li>\n<li>Pervasive developmental disorder or autism</li>\n<li>Significant developmental disorder (e.g., blindness, deafness, cerebral palsy, epilepsy, psychosis)</li>\n<li>Taking another psychotropic medication that cannot be discontinued</li>\n<li>Serious psychiatric disorder (e.g., bipolar, suicidality, tic disorder)</li>\n<li>Actively taking medication for certain medical conditions (e.g., hypertension, structural cardiac condition, glaucoma, hyperthyroidism)</li>\n<li>Allergy to mixed amphetamine salts</li>\n<li>History of physical, sexual, or emotional abuse that is clinically significant</li>\n</ul>\n</p>', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:a97f9ee764fd58ba2f27e28eaa04fbc5' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Composite Parent and Teacher Conners Rating Scale Score [&nbsp;Time&nbsp;Frame:&nbsp;Measured weekly for 6 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:e9117a6843d4a30da7589a79766c3f96' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Tolerance of extended release mixed amphetamine salts [&nbsp;Time&nbsp;Frame:&nbsp;Measured weekly for 6 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:97e162d90e5e7d2084bdae7bda203624' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:68bd7cb1d3910457c363525a6fbc1d30' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The proposed study will use both qualitative and quantitative research methods (mixed methods) to gather data that will support the eventual development of interventions for young men who have sex with men (YMSM) living with behaviorally acquired HIV infection. The overall goal of the study is to gain an understanding of the psychosocial/developmental needs of YMSM by focusing on two critical developmental issues&#8212;identity development and future life goals.</p>\n', created = 1283571991, expire = 1283658391, headers = '', serialized = 0 WHERE cid = '1:68bd7cb1d3910457c363525a6fbc1d30' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3d58fd90c5aff36addfc7582cfd47001' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate the effectiveness of a community-level HIV prevention program in promoting safer sexual behaviors and reducing the transmission of HIV/sexually transmitted diseases among at-risk populations in China, India, Peru, Russia, and Zimbabwe.</p>\n', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:3d58fd90c5aff36addfc7582cfd47001' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2f293722624e490e0633c0bae266a05f' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>NIMH Collaborative HIV/STD Prevention Trial</p>\n', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:2f293722624e490e0633c0bae266a05f' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9923da2e5b5fc7b58e5e301835a5dddf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The HIV/AIDS epidemic remains largely out of control in many areas of the world, with an estimated 2.5 million new HIV infections worldwide in 2007. Developing countries with few economic resources and world regions undergoing difficult social transitions have been particularly impacted by large increases in HIV and sexually transmitted disease (STD) infections. To date, effective individual prevention approaches have not been rapid enough to avert the epidemic in these areas and may be too resource intensive to maintain. Behavioral HIV prevention interventions on the community level seek to reduce the prevalence of high-risk sexual behaviors by reaching large numbers of vulnerable people in a cost-effective and feasible manner, even in areas with limited resources. The Community Popular Opinion Leader (C-POL) program is an HIV prevention intervention that recruits and trains trusted opinion leaders in the community to promote safe sex behaviors through risk-reduction conversations with peers. Implementing the C-POL program in world regions facing significant HIV/AIDS epidemics may be the most effective means of encouraging behavior change among members of at-risk populations and strengthening social norms to maintain these changes. This study will evaluate the effectiveness of the C-POL program in promoting safer sexual behaviors and reducing the transmission of HIV/STDs among at-risk populations in China, India, Peru, Russia, and Zimbabwe. Participation in this study will last 2 years. Initially, an ethnographic study will be conducted to determine the HIV/STD knowledge, attitudes, and behaviors among the population living in the target communities. Information collected via observation, focus groups, and interviews will be used to determine the social risk groups operating within the community and to identify and recruit the opinion leaders who are influential in these groups. Also, an epidemiological study will be conducted to collect information on sexual behaviors and HIV/STD rates. A cohort of members from participating communities will first undergo baseline assessments that will include a survey about general health and knowledge of HIV/STDs and a biological sampling for HIV/STD testing. Participating communities will then be assigned randomly to receive the C-POL intervention and HIV/STD educational materials or HIV/STD educational materials alone. In communities receiving the C-POL intervention, the previously recruited opinion leaders will be taught skills for sharing HIV risk-reduction messages in daily conversation with peers. This training will occur over four to five weekly sessions. At least 15% of the community population will be trained as opinion leaders. After the initial training, opinion leaders will attend six to nine booster sessions over the next 2 years to reinforce and support continued conversation efforts. Communities assigned to receive the HIV/STD educational materials will receive informational materials on HIV/STDs to provide to community members and will provide treatment or treatment referral for people with nonviral STDs. All participants in the baseline cohort will be asked to repeat the baseline testing 1 and 2 years later. Participants who are not able to visit a clinic for testing will be contacted by phone to complete the baseline survey. After the 2-year assessments, the C-POL intervention will be conducted in the communities that received educational materials only.</p>\n', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:9923da2e5b5fc7b58e5e301835a5dddf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4e2ee49c8cf1ff5af28ebec2249c7a50' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Either lives, works, or socializes in the selected venues</li>\n<li>Plans to remain in the venue for at least 1 year after study entry</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Permanent disability that hinders participation (e.g. deaf, mental retardation)</li>\n<li>Reports no sex in the 6 months before study entry (China, Peru)</li>\n<li>No STDs present at study entry (China)</li>\n<li>Enrolled in final year of school at time of recruitment (Russia)</li>\n<li>Has lived in venue for less than 2 years (Zimbabwe)</li>\n<li>Lives in venue for less than 9 months out of a year (Zimbabwe)</li>\n</ul>\n</p>', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:4e2ee49c8cf1ff5af28ebec2249c7a50' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of unprotected sexual acts with nonspousal partners [&nbsp;Time&nbsp;Frame:&nbsp;Measured at baseline and Years 1 and 2&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:197d8d01b34a26f30db228713cb64f0d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8cd06a88466f5ea5c5a23d0d867cdc6f' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will evaluate the effectiveness of a cognitive behavioral treatment in reducing significant medical risk factors often associated with people who have a serious mental illness and are taking atypical antipsychotic medications.</p>\n', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:8cd06a88466f5ea5c5a23d0d867cdc6f' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Behavioral Intervention to Reduce Novel Antipsychotic Medication Health Risks</p>\n', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:c24dfda1e171fb2e2e31c94605358b19' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:eacafa3e2b41fda630706ac763c80e23' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Serious mental illness encompasses a large range of symptoms varying in severity, but generally includes symptoms described as both positive and negative. Positive symptoms include confused thinking, delusions, and hallucinations, while negative symptoms include lack of emotion and depression. Because novel or atypical antipsychotic medications target both positive and negative symptoms and have fewer side effects than other medications, they make up the current standard of care for the treatment of many mental illnesses. However, there is growing concern that the psychiatric benefits associated with atypical antipsychotic medications are offset by serious negative medical consequences, including weight gain, obesity-related cardiovascular risk, insulin resistance, and diabetes. Behavioral interventions that aim to help people coping with serious mental illness to reduce weight, sustain weight loss, and achieve better fitness may improve the risk/benefit ratio of atypical antipsychotic medications. A small-group cognitive behavioral intervention that provides peer and structural risk-reduction support may be the most beneficial means of promoting healthy eating and exercise habits in people with serious mental illness who are living in group homes. This study will evaluate the effectiveness of a small-group cognitive behavioral intervention conducted in group homes for reducing significant medical risk factors often associated with people who have a serious mental illness and are taking atypical antipsychotic medications. Participation in this study will last about 18 months through follow-up. All participants will undergo baseline assessments that will include the following: measurements of diet and exercise patterns, using self-report and observational methods; measurements of weight, body mass index, body fat distribution, pulse rate, and blood pressure; blood draws; and questions about psychological well-being and quality of life. Group homes will then be assigned randomly to provide participating residents with either the cognitive behavioral intervention or the time-matched attention control program. Participants in both groups will receive 26 weekly 1-hour small-group sessions and 26 weekly 30-minute individual sessions with a study facilitator. The cognitive behavioral sessions will focus on promoting healthy behaviors, dieting, and exercise. The time-matched attention control sessions will focus on improving communications, developing healthy techniques for coping with stress, and resolving conflicts. After completing treatment, all participants will receive 6 monthly 1-hour booster sessions of their assigned treatments. They will also repeat the baseline assessments 3 times over the following 12 months.</p>\n', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:eacafa3e2b41fda630706ac763c80e23' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Resides in one of the designated group homes</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Sufficiently impaired because of a psychiatric illness, as reflected in mental status in which informed judgment about study participation cannot be assured at the time of study entry</li>\n<li>Medical contraindication to study participation</li>\n</ul>\n</p>', created = 1283571992, expire = 1283658392, headers = '', serialized = 0 WHERE cid = '1:2dcef3cd81cace2256b51254dcb8df86' in /persistent/html/includes/cache.inc on line 109.
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Family Centered Advanced Care Planning for Adolescents With HIV/AIDS and Their Families

This study will examine the efficacy of Family Centered Advance Care Planning in enhancing quality of life, integrating effective end-of-life care, and preventing depression and anxiety among HIV infected adolescents and their family members.

Background information
Other unique IDs: 
DAHBR 9A-ASPA
R34 MH072541

Effectiveness of Anger Management Treatment in Reducing Anger-Related Behaviors in Female Juvenile Offenders

This study will evaluate the effectiveness of an anger management treatment program, Juvenile Justice Anger Management for Girls, in reducing anger-related behaviors displayed by girls in the juvenile justice system.

Background information
Other unique IDs: 
DSIR 82-SEMS
K23 MH070400

Identifying Predictors of Bipolar Disorder Relapse During Pregnancy and the Postpartum Period

This study will evaluate pregnant women who have bipolar disorder to gain a better understanding of risk factors for bipolar disorder relapse during pregnancy and the postpartum period.

Background information
Other unique IDs: 
R01 MH085026
DATR A2-AIE

Effectiveness of a Technology Assisted Behavioral Intervention in Assisting People With Major Depressive Disorder

Trial phase: 
Phase I
Recruitment status: 
Not yet recruiting

This study will develop and evaluate the effectiveness of a technology-assisted behavioral intervention, consisting of Internet-based cognitive behavioral therapy combined with telephone and email support, in reducing depressive symptoms and improving treatment adherence in primary care patients with major depressive disorder.

Background information
Trial ID: 
NCT00719979
Other unique IDs: 
DSIR 83-ATP
R34 MH078922
Official title: 

Integrated Telemental Health Intervention for Depression in Primary Care

Detailed description: 

Major depressive disorder (MDD) is a common mental disorder, with up to 10.3% of the population experiencing the disorder in a given 12-month period. Symptoms of MDD include feelings of anxiety, guilt, or hopelessness; irregular sleep and appetite patterns; lethargy; excessive irritability and restlessness; inability to concentrate; and lack of enjoyment in previously enjoyed activities. Fortunately, MDD is treatable with forms of psychotherapy and/or antidepressant medications.

Number to be enrolled: 
70 patients

Effectiveness of an Extended Release Stimulant Medication in Treating Preschool Children With Attention Deficit Hyperactivity Disorder (The APS Study)

Recruitment status: 
Recruiting

This study will evaluate the safety and effectiveness of extended release mixed amphetamine salts in treating preschool children with attention deficit hyperactivity disorder.

Background information
Trial ID: 
NCT00712699
Other unique IDs: 
F32 MH078388
DDTR BK-TKFND
Official title: 

Placebo vs. Extended Release Stimulant Crossover Trial in Preschoolers With ADHD

Detailed description: 

Attention deficit hyperactivity disorder (ADHD) is a common developmental disorder that affects between 4% and 12% of school-aged children. Children with ADHD often show symptoms of hyperactivity, inattention, inability to sit still, trouble listening, excessive talking, and aggression. ADHD is generally not diagnosed and treated in children less than 6 years old because some symptoms of ADHD are difficult to distinguish from normal behaviors of preschool-aged children.

Number to be enrolled: 
30 patients

Psychosocial Needs of YMSM

The proposed study will use both qualitative and quantitative research methods (mixed methods) to gather data that will support the eventual development of interventions for young men who have sex with men (YMSM) living with behaviorally acquired HIV infection. The overall goal of the study is to gain an understanding of the psychosocial/developmental needs of YMSM by focusing on two critical developmental issues—identity development and future life goals.

Background information
Other unique IDs: 
ATN 070

Effectiveness of a Community-Level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-Risk Populations

Trial phase: 
Phase III
Recruitment status: 
Completed

This study will evaluate the effectiveness of a community-level HIV prevention program in promoting safer sexual behaviors and reducing the transmission of HIV/sexually transmitted diseases among at-risk populations in China, India, Peru, Russia, and Zimbabwe.

Background information
Trial ID: 
NCT00710060
Other unique IDs: 
U10 MH61537
U10MH061499
U10MH061513
U10MH061536
U10MH061543
U10MH061544
DAHBR 9A-ASGT
Official title: 

NIMH Collaborative HIV/STD Prevention Trial

Detailed description: 

The HIV/AIDS epidemic remains largely out of control in many areas of the world, with an estimated 2.5 million new HIV infections worldwide in 2007. Developing countries with few economic resources and world regions undergoing difficult social transitions have been particularly impacted by large increases in HIV and sexually transmitted disease (STD) infections. To date, effective individual prevention approaches have not been rapid enough to avert the epidemic in these areas and may be too resource intensive to maintain.

Number to be enrolled: 
18147 patients

Effectiveness of a Cognitive Behavioral Treatment for Reducing Atypical Antipsychotic Medication Health Risks in People With Serious Mental Illness

Trial phase: 
Phase I
Recruitment status: 
Enrolling by invitation

This study will evaluate the effectiveness of a cognitive behavioral treatment in reducing significant medical risk factors often associated with people who have a serious mental illness and are taking atypical antipsychotic medications.

Background information
Trial ID: 
NCT00709345
Other unique IDs: 
DAHBR 96-BHB
R01 MH078576
Official title: 

Behavioral Intervention to Reduce Novel Antipsychotic Medication Health Risks

Detailed description: 

Serious mental illness encompasses a large range of symptoms varying in severity, but generally includes symptoms described as both positive and negative. Positive symptoms include confused thinking, delusions, and hallucinations, while negative symptoms include lack of emotion and depression. Because novel or atypical antipsychotic medications target both positive and negative symptoms and have fewer side effects than other medications, they make up the current standard of care for the treatment of many mental illnesses.

Number to be enrolled: 
333 patients

Effectiveness of Collaborative Depression Care Management in Treating Depressed Low-Income Hispanics With Diabetes

This study will evaluate the effectiveness of culturally adapted depression treatment for reducing depressive symptoms and improving adherence to diabetes self-care regimens in Hispanics with depression and diabetes.

Background information
Other unique IDs: 
R01 MH068468
DSIR 82-SESQ

PharmacofMRI of Anxiolytic Medications (Pregabalin)

The purpose of this study is to use functional magnetic resonance imaging (fMRI) in healthy controls to examine the acute effects of certain anxiolytic medications on brain function. In this case, the medication pregabalin will be used. The investigators hypothesize that pregabalin (at doses of 50 mg and 200 mg, versus placebo) will yield a reduction in amygdala and insula activity (in a dose-dependent fashion) during emotion processing using fMRI.

Background information
Other unique IDs: 
UCSD IRB 060407 - B
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