RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.

We will evaluate the records of 30 patients that have undergone allogeneic transplant, specifically looking at engraftment rate, relapse rate, disease free survival, overall survival, causes of death and other pertinent statistics. We will compare the outcomes to appropriate historical controls.

Investigate hypothesis that real-time, MR-guided laser induced thermal ablation of brain lesions under real-time thermal imaging guidance is both a feasible and safe minimally-invasive technique for local, highly conformal therapy of metastatic brain tumors.

Primary Objectives:

1. To assess the efficacy of presurgical sunitinib therapy by evaluating time to progression.
2. Toxicities of therapy with sunitinib in RCC in the context of presurgical therapy.

Secondary (Clinical) Objectives:

1. Response rate
2. Duration of response
3. Overall Survival

The goal of this clinical research study is to find the highest safe dose of the drug 8-chloro-adenosine that can be given in the treatment of CLL. Another goal is to learn how effective the drug is at treating leukemia.

We know that treatment for rectal cancer can impact women's sexual function. Cancer patients seek counseling for lots of reasons. It often helps them cope because they can express their feelings with a trained professional. This study is open to women who have been treated for rectal cancer. It involves a new type of counseling. It will teach women skills that they can use to improve their sex lives. These skills may also improve physical and emotional well-being. We will compare the new type of counseling with the standard care women receive after treatment for rectal cancer.

Primary Objectives:

• To determine the clinical/radiographic complete and partial response rate after induction chemotherapy with docetaxel, cisplatin and fluorouracil (TPF)
• To improve local tumor control to 80% at 2 years

Secondary Objectives:

• Disease specific-survival and overall survival rates
• Organ preservation (orbital, maxillary, cranial) rate
• Patterns of treatment failure (local, regional, and distant)
• Acute and late treatment-related toxicity
• The effect of treatment on Quality of Life with and without surgery
• To evaluate the effects of induction chemotherapy on biological markers that could serve as surrogates for response and predictors of long-term outcome.

Primary: 1. To determine reliability of glucose monitoring device as compared with point of care / fingerstick glucose testing. Secondary:

1. To determine what conditions, if any, where continuous glucose monitoring device may not be reliable.
2. To determine if the continuous glucose monitor provides more clinically important information for determining insulin infusion protocol changes as compared with point-of-care testing.

The purpose of this study is to find out the effects (good and bad) Alpha-Lipoic Acid (ALA) has on preventing a side effect of platinum-containing chemotherapy called peripheral neuropathy. In this study, one group of subjects will receive Alpha-Lipoic Acid (ALA) and another group will receive a placebo control pill. A placebo control pill is a "look-a-like" pill but does not have any medication in it. Another name for placebo pill is "sugar pill." Peripheral neuropathy is an abnormal, uncomfortable, often painful, sensations and feelings in hands or feet. The sensations and feelings in the hands and feet can effect the normal use of the hands and feet, such as in buttoning, writing, typing, sewing, picking up small objects, and walking. Currently there is no standard or reliable therapy to prevent this type of neuropathy. Alpha-Lipoic Acid (ALA) is a dietary supplement that is supposed to prevent or reduce the symptoms.

Primary Objectives:

• Evaluate safety, feasibility, persistence, and anti-tumor effect of infused haploidentical donor-derived natural killer (NK) cells and low-dose interleukin-2 (IL-2).

Secondary Objectives:

• Quantification of cytokine levels;
• Assessment of NK cell immunophenotype and function.