Assistance Publique - Hôpitaux de Paris

  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fce55512905ffaa65851f935d24e5ee4' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The objective of the study is to evaluate how the use of OncoDoc2, a computerized guideline-based decision support system, could improve the compliance of multidisciplinary staff meeting decisions with local clinical practice guidelines in the management of non-metastatic breast cancer.</p>\n', created = 1283939161, expire = 1284025561, headers = '', serialized = 0 WHERE cid = '1:fce55512905ffaa65851f935d24e5ee4' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e275cf2379dfef1159eb07d1fb082e79' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Impact of the OncoDoc2 Decision Support System on Compliance of Multidisciplinary Staff Meeting Decisions With Clinical Practice Guidelines in the Management of Non-Metastatic Breast Cancer.</p>\n', created = 1283939161, expire = 1284025561, headers = '', serialized = 0 WHERE cid = '1:e275cf2379dfef1159eb07d1fb082e79' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cdc77fad425aa1494089dbc581545880' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>In France, to promote the quality of cancer care, decisions have currently to be made according to clinical practice guidelines (CPGs) during regularly organized multidisciplinary staff meetings (MSMs). Dissemination of textual CPGs has a poor impact on clinical practice as opposed to the use of clinical decision support systems (CDSSs) known to improve compliance with CPGs. OncoDoc2 is a CDSS providing patient-specific recommendations based on CPGs for non-metastatic female breast cancer management elaborated by the CancerEst INTERMEDICAL collaboration.The main goal of the study is to evaluate the effect of the routine use of OncoDoc2 during MSMs on compliance of MSM decisions with local CPGs. Impact will be measured by the compliance rate of MSM decisions with OncoDoc2 recommendations. The design of the study relies on a cluster randomized controlled trial. Under the assumption of a baseline compliance rate of 70% without intervention, an expected compliance rate of 90% in the intervention group (&#945; = 5%, &#946; = 20%), an inter-cluster variability of 5%, and 59 decisions per center, the required number of centers is 3 in each group, or 177 decisions in each arm. The study will be conducted in cancer care centers (public and private) from Paris area, France.This prospective trial will be conducted in two steps. First, baseline compliance rates will be measured in each center. Then, the 6 centers will be randomized into 2 arms. In the intervention arm, OncoDoc2 will be used during MSMs at decision time. Every case of non-adherence with system recommendations will have to be justified by clinicians. In both arms and after each MSM, MSM decisions will be recorded as well as patient characteristics and OncoDoc2 will be used for each patient case to get system recommendations. In the intervention arm, OncoDoc2 recommendations obtained by MSM will also be recorded, as well as the reason for non following recommendations in case MSM decision does not comply with guidelines.</p>\n', created = 1283939161, expire = 1284025561, headers = '', serialized = 0 WHERE cid = '1:cdc77fad425aa1494089dbc581545880' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:272458085a0d5f30758374d2cc784741' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Non metastatic, including invasive and in situ, breast cancers as well as axillary cancer without breast tumor.</li>\n<li>At least one therapeutic MSM decision.</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Breast disease without cancer</li>\n<li>Metastatic breast cancer</li>\n<li>Male breast cancer</li>\n<li>Breast cancer cases when medical records are not accessible to investigators</li>\n<li>Management but not therapeutic breast cancer decisions (diagnostic investigations, treatment follow-up, delayed decisions&#8230;)</li>\n</ul>\n</p>', created = 1283939161, expire = 1284025561, headers = '', serialized = 0 WHERE cid = '1:272458085a0d5f30758374d2cc784741' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b229e978d9e535e1a169a174c714f6b5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>typology of non-compliant reasons for both MSM decisions and treatments administration [&nbsp;Time&nbsp;Frame:&nbsp;at 18 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939161, expire = 1284025561, headers = '', serialized = 0 WHERE cid = '1:b229e978d9e535e1a169a174c714f6b5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a32c0435868de888df8b6bb52afe34fc' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>patient profiles associated with non-guideline-compliant therapeutic decisions. [&nbsp;Time&nbsp;Frame:&nbsp;at 18 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939161, expire = 1284025561, headers = '', serialized = 0 WHERE cid = '1:a32c0435868de888df8b6bb52afe34fc' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:259b3e84228768cc0d0290b373d6ec20' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Oxaliplatin is a major antitumor agent but its use is limited by potentially disabling neurotoxicity, characterized by a sensitive defect in the extremities.Mangafodipir is a MRI contrast agent with antioxidant properties. Our previous laboratory works showed that mangafodipir is able to prevent hematologic toxicity of several chemotherapy agents, including oxaliplatin and to increase their antitumor activity. Preliminary clinical data suggested that mangafodipir could prevent oxaliplatin neurotoxicity.The primary purpose of the present study is to assess the protective effect of mangafodipir in patients who have a already moderate oxaliplatin neuropathy and in whom the continuation of this treatment is desirable because of significant antitumor effect.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:259b3e84228768cc0d0290b373d6ec20' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f3f624a818c83f0b8713f1e3f94bc83a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Evaluation of Mangafodipir Protective Activity Against Oxaliplatin Neurotoxicity</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:f3f624a818c83f0b8713f1e3f94bc83a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4fe78882a24e574ccc5f7fa44ba63e03' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Phase 2 study aiming to assess the protective effect of mangafodipir against the oxaliplatine neuropathy.Population: Cancer patient who have a mild (grade 2) oxaliplatin neuropathy and in whom the continuation of oxaliplatin for at least 4 infusions is desirable will be include, whatever the location of the primitive tumor and the use of others anticancer agents.Treatment: Mangafodipir (0.5 ml/kg) is administered as a 30 minutes infusion just after each administration of oxaliplatin. The oxaliplatin dose (85 to 100 mg/m&#178;) and the length of the infusion (2 hours) are the same that before the inclusion and modifications are not authorized during all the study participation. Primary objective: Neuropathy are clinically evaluated according to NCI-CTC criteria before each mangafodipir and oxaliplatin and thereafter one month after the last infusion. The primary criteria is the worst grade of oxaliplatin neuropathy experienced by each patient. The improvement of neuropathy is defined as a decrease by at least one grade of the severity of the neuropathy for at least 2 months. Hypothesis: at least 50% of patients will experience an improvement or a stabilization of the oxaliplatin neuropathy while receiving the mangafodipir - oxaliplatin association.Treatment discontinuation: the treatment will be stopped if the neuropathy worsened by at least one grade, in case of tumor progression, intolerable toxicity, and patient wish. Number of patients: it will be determined according to a simplified Gehan procedure: The inclusions will be stopped if no objective response (neuropathy improvement) is observed among the first 9 evaluable patients. If at least one response is observed, 16 more evaluable patients will be include. The total number of patients will be between 9 and 30 patients, including non evaluable patients. Pharmacokinetic: Serum and intra- erythrocytes manganese concentration will be evaluated before each mangafodipir infusion in order to detect accumulation Pharmacodynamic: plasmatic total antioxidant activity, superoxide dismutase activity and lipid peroxidation will be assessed at the first cycle: before and after the administration of oxaliplatin and just after the perfusion of mangafodipir.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:4fe78882a24e574ccc5f7fa44ba63e03' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5568258d99d6c07a469287aa5f2d6a96' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>NCI CTC grade 2 or more neuropathy induced by oxaliplatine</li>\n<li>At least 18 years old</li>\n<li>ECOG PS: 2 or less</li>\n<li>Life expectancy longer than 3 months</li>\n<li>Written informed consent</li>\n<li>Adequate hematologic, liver and renal functions</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Known hypersensibility to oxaliplatine</li>\n<li>Cancer resistant to oxaliplatine</li>\n<li>Fertile woman or man not willing to use adequate contraception</li>\n<li>Pregnant or lactating women</li>\n<li>Vitamin B6 administration within 48h prior to mangafodipir administration</li>\n<li>Uncontrolled infection</li>\n<li>Treatment with any other investigational agent, or participation in another clinical trial within 3 weeks prior to first administration of mangafodipir</li>\n<li>Evidence of any other disease or condition that contra-indicates the use of an investigational drug</li>\n<li>No Social Security insurance</li>\n</ul>\n</p>', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:5568258d99d6c07a469287aa5f2d6a96' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5b795313556d7b3c4219cd82e74495d9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Number of oxaliplatin administration [&nbsp;Time&nbsp;Frame:&nbsp;every 15 days&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:5b795313556d7b3c4219cd82e74495d9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a9b4fa475a98e013336fbc1f36cfbd51' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Progression free survival (time from inclusion to cancer progression) [&nbsp;Time&nbsp;Frame:&nbsp;6 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:a9b4fa475a98e013336fbc1f36cfbd51' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:feb99b66cc81a714594b59c6095b2916' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to evaluate the effectiveness of ARTHRO distension plus intensive mobilisation in shoulder capsulitis.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:feb99b66cc81a714594b59c6095b2916' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:00e4bd9b984e01ec24d9dde4995d5cbf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Evaluation of the Effectiveness of ARTHRO -Distension Plus Intensive Mobilisation in Shoulder Capsulitis</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:00e4bd9b984e01ec24d9dde4995d5cbf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:891b5dba4936663b78fc6411640edc29' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The aim of the study is to evaluate a treatment of shoulder capsulitis that associates ARTHRO distension and intensive mobilisation at 2, 6, 12, 26 and 52 weeks. It is a bicentric 48-month (inclusion: 36 months; follow up: 12 months) observer blind randomised clinical trial using 2 groups in parallel. The number of patients to be included is 58. The treatment that is evaluated associates ARTHRO distension followed by mobilisation of the shoulder 6 hours per day during 5 days, and then sessions of physiotherapy for 4 weeks. The control intervention is one intra-articular injection of corticosteroids and physiotherapy. The primary outcome is SPADI, namely pain and disability, at 2 weeks.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:891b5dba4936663b78fc6411640edc29' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:828e878a80a1127e04e0504cd3c17771' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>age &#8805; 18 years</li>\n<li>shoulder capsulitis</li>\n<li>duration of symptoms &#8805; 3 months</li>\n<li>health insurance</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>cognitive disorders</li>\n<li>Hypo coagulation</li>\n<li>biological inflammatory syndrome</li>\n<li>uncontrolled diabetes</li>\n<li>xyloca&#239;ne allergy</li>\n<li>pregnancy</li>\n<li>unable to understand and to speak french</li>\n<li>previous surgery of shoulder</li>\n<li>shoulder infiltration or distension in the previous month</li>\n<li>local contraindication to shoulder infiltration</li>\n</ul>\n</p>', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:828e878a80a1127e04e0504cd3c17771' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:445a550852fea68f4358e65ab76a1d03' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The aim of this study is to assess that the sleeve gastrectomy can improve the risk benefit than the gastric bypass</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:445a550852fea68f4358e65ab76a1d03' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6b3264f9486647c25559ec2b4612b263' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Surgical Treatment for Morbid Obesity by Sleeve Gastrectomy Versus Gastric Bypass Randomised Study Comparing Complications, Efficacy and Quality of Life</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:6b3264f9486647c25559ec2b4612b263' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:641c06b705225805de78b008f73c78c7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>In the obese patient population, the frequency of patients presenting a severe morbid obesity (45 &gt;= BMI &lt;= 50), a super obesity (BMI &gt;50), a super super obesity (BMI&gt;60), and obese patients (BMI&gt;40) with a failure of gastric banding is constantly increasing. In these patients, the surgery risk is proportionate to the weight and / or gastric surgery records. This risk is high, in bariatric surgery, for gastric bypass procedure. This justifies the evaluation of new procedure to reduce the morbidity allowing the reduction of morbid /mortality associated with the intervention.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:641c06b705225805de78b008f73c78c7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:324100fe999987135894fae3f5076983' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Patient aged from 18 to 60 years old</li>\n<li>Patient having given his consent to the use of data from the project</li>\n<li>Patient fulfilling the inclusion criteria for surgery of obesity according to the ANAES (french national health service)</li>\n<li>Patient presenting one of the following criteria:\n<ul>\n<li>A morbid obesity strict with BMI&gt; 45</li>\n<li>A super obesity BMI&gt; 50</li>\n<li>A super super obesity BMI&gt; 60</li>\n<li>Obese patient in failure following the installation of a gastric banding with BMI&gt; 40</li>\n</ul>\n</li>\n<li>Preliminary agreement during the consultation of a psychiatrist / psychologist</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Patient with complications or co morbidities associated involving life to less 6 months</li>\n<li>Patient presenting no anaesthetic indication</li>\n<li>Patient presenting no psychiatric indication for obesity surgery</li>\n<li>Patient not affiliated with a social security scheme</li>\n<li>Pregnant Patient likely to breastfeed in the first year</li>\n</ul>\n</p>', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:324100fe999987135894fae3f5076983' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:73b56a7a897f3e148482c41dedbb8808' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of morbid events [&nbsp;Time&nbsp;Frame:&nbsp;during the follow up&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:73b56a7a897f3e148482c41dedbb8808' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fee89dff423f987ba6f194ce7c85281c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage of excess weight loss [&nbsp;Time&nbsp;Frame:&nbsp;during 18 and 36 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:fee89dff423f987ba6f194ce7c85281c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:118039b204e889dce3ac11033008269e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of patients having a excess weight loss superior than 50% [&nbsp;Time&nbsp;Frame:&nbsp;during 36 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:118039b204e889dce3ac11033008269e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:26970ccf3b923c255989290cd83ad4ec' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Regression of morbidities [&nbsp;Time&nbsp;Frame:&nbsp;during 36 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:26970ccf3b923c255989290cd83ad4ec' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cd86e85656c07d1d1a2eb7e5c535feb4' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Rate serum ghrelin [&nbsp;Time&nbsp;Frame:&nbsp;at inclusion visit, 6, 12, 18 and 36 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:cd86e85656c07d1d1a2eb7e5c535feb4' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:734b93f803f46dfe005ceb4742cfc188' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of morbid/mortality events [&nbsp;Time&nbsp;Frame:&nbsp;during 36 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:734b93f803f46dfe005ceb4742cfc188' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e106b84c58ba55919ee2750ff3e6c11a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of patients having excess weight loss superior than 50% [&nbsp;Time&nbsp;Frame:&nbsp;during 18 month&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:e106b84c58ba55919ee2750ff3e6c11a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:107e3f3f760f81d59a229c7a40dbb083' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to test the effectiveness of an antibiotic treatment (Josamycin) in the case of positive PCR for Ureaplasma spp. and/or Mycoplasma hominis in the second quarter on the risk of premature birth.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:107e3f3f760f81d59a229c7a40dbb083' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:11078db59750295d971d13d61a0a722a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Antenatal :occurence of a miscarriage late [&nbsp;Time&nbsp;Frame:&nbsp;between 16 and 22 weeks of amenorrhoea&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:11078db59750295d971d13d61a0a722a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:122f75a9b196c56dcba7987f9bce7954' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Antenatal : premature delivery [&nbsp;Time&nbsp;Frame:&nbsp;at week of amenorrhea &lt;= 34, 32, 28&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:122f75a9b196c56dcba7987f9bce7954' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3381d0c46eba342359b3823a5b319fdf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Antenatal : hospitalisation for risk of premature delivery [&nbsp;Time&nbsp;Frame:&nbsp;antenatal period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:3381d0c46eba342359b3823a5b319fdf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c50d11d02ae801b6c54cb304343660ed' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>antenatal : Number of day of hospitalisation for risk of premature delivery [&nbsp;Time&nbsp;Frame:&nbsp;antenatal period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:c50d11d02ae801b6c54cb304343660ed' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7bc76f82737764e95ec5630286435fd4' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Antenatal : premature rupture of membranes [&nbsp;Time&nbsp;Frame:&nbsp;before 37 week of amenorrhea&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:7bc76f82737764e95ec5630286435fd4' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:18bc03b2f7f0e5a248392dfeed0afd00' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>During childbirth : Hyperthermia &gt; 38&#176;C [&nbsp;Time&nbsp;Frame:&nbsp;Childbirth period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:18bc03b2f7f0e5a248392dfeed0afd00' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ebf2b2a496cffda9a80a85fa55afc101' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>During childbirth : fetal tachycardia &gt; 160 bpm [&nbsp;Time&nbsp;Frame:&nbsp;childbirth period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:ebf2b2a496cffda9a80a85fa55afc101' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ca5f371cef2f74b2c47f352ae47adad1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Post-partum : Hyperthermia &gt; 38&#176;C for more than 24hours [&nbsp;Time&nbsp;Frame:&nbsp;post partum period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:ca5f371cef2f74b2c47f352ae47adad1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0c67430f7cf85e733541c1b1d6416c70' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Post partum :need an antibiotic treatment for more than 48 hours [&nbsp;Time&nbsp;Frame:&nbsp;post partum period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:0c67430f7cf85e733541c1b1d6416c70' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:85e1bc696a7ab55d19784caa62c33bd7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Neonatal : neonatal mortality late [&nbsp;Time&nbsp;Frame:&nbsp;from day 7 to day 28&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:85e1bc696a7ab55d19784caa62c33bd7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:91f523e8ea0219168753da3516b8a83c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Neonatal : early neonatal mortality [&nbsp;Time&nbsp;Frame:&nbsp;from day 0 to day 6&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:91f523e8ea0219168753da3516b8a83c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:58808dffb42888a36baf8ebdb07f245c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Neonatal morbidity : immediate neonatal state [&nbsp;Time&nbsp;Frame:&nbsp;neonatal period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:58808dffb42888a36baf8ebdb07f245c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8b1739f2a229aef061c01f8d44079558' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Neonatal morbidity : infection [&nbsp;Time&nbsp;Frame:&nbsp;neonatal period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:8b1739f2a229aef061c01f8d44079558' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ae05f576c16bbac46c23c42cb4c9589e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Neonatal morbidity : respiratory disease [&nbsp;Time&nbsp;Frame:&nbsp;neonatal period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:ae05f576c16bbac46c23c42cb4c9589e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a4bbafc655bc660d439a58c0ea5970b1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Neonatal morbidity : digestive disease [&nbsp;Time&nbsp;Frame:&nbsp;neonatal period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:a4bbafc655bc660d439a58c0ea5970b1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bc3dbcaff00c3e566e6bd255df5a140e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Randomized evaluation of enoxaparin (0.5mg/kg IV) versus UFH (50-70IU/kg with GPIIb/IIIa inhibitors; 70-100IU without GPIIb/IIIa inhibitors). Anticoagulation can be continued after the procedure using the same agents as those allocated per randomization (enoxaparin SC, UHF IV or SC)</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:bc3dbcaff00c3e566e6bd255df5a140e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4b45e070c4575c76aeb667f0b8742b64' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Acute STEMI Treated With Primary Angioplasty and Intravenous 0.5 mg/kg Lovenox or UFH to Lower Ischemic and Bleeding Events</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:4b45e070c4575c76aeb667f0b8742b64' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:545f061a6678d2aa39796d3b792fe3e0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study is a prospective, multicenter, multinational, randomized, active-control arm trial. The study population consists of subjects with ST-segment elevation MI who are randomized within 24 hours of symptom onset. Subjects presenting between 12 and 24 hours of symptom onset should present with recurrent or persisting chest pain and/or recurrent or persisting ST elevation suggesting ongoing ischemia, and an indication of primary PCI. Approximately 850 subjects will be enrolled at approximately 50 sites in several countries including Austria, France, Germany and the United States. Informed consent will be obtained from subjects meeting all inclusion and no exclusion criteria prior to any study related procedures. Subjects will be randomized and begin treatment in the Emergency Department or in the ambulance or in the hospital room if in-patient. Eligible subjects will be randomized (1:1) to receive either UFH IV bolus (ACT-adjusted) or enoxaparin 0.50 mg/kg IV bolus without monitoring. Randomization to treatment group will be performed using an interactive voice response system (IVRS). All treatment groups will be given aspirin (160 to 500 mg/day according to local practice) and clopidogrel (300 to 900mg as loading dose according to local practice). All other concomitant medications will be consistent with local standard of care.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:545f061a6678d2aa39796d3b792fe3e0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a5b5c86ab927342057070e06ad69c32b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ol>\n<li>Be at least 18 years of age.</li>\n<li>Has experienced continuous ischemic (cardiac) symptoms for at least 20 minutes.</li>\n<li>Has onset of symptoms of qualifying acute MI within the past 24 hours, and planned for primary PCI. Patients presenting between 12 and 24 hours of symptom onset should still have an indication for primary PCI, i.e. persistent ischemic symptom and/or persistent or recurrent ST elevation</li>\n<li>Has an ECG indicative of an acute STEMI showing:\n<ul>\n<li>&#8805; 2 mm ST elevation in 2 or more contiguous precordial ECG leads (anterior infarction); or</li>\n<li>&#8805; 1 mm ST elevation in 2 or more contiguous limb ECG leads (other infarction); or</li>\n<li>New or presumably new left bundle branch block (LBBB)</li>\n</ul>\n</li>\n<li>Shock patients are eligible (but not patients with prolonged cardiac arrest)</li>\n<li>Be willing to provide informed consent (informed consent may be provided by a legally authorized representative if the patient is not able to provide it).</li>\n<li>Agree to comply with all protocol-specified procedures, including protocol-mandated follow-up</li>\n</ol>\n</p><p> Exclusion Criteria:\n<ol>\n<li>Use of UFH or LMWH or any other anticoagulant agent (Vit K antagonists, fondaparinux, bivalirudin) within 48 hours prior to randomization</li>\n<li>Thrombolytic therapy within the previous 48 hours</li>\n<li>Known or suspected pregnancy in women of childbearing potential</li>\n<li>History of hypersensitivity or contraindication to heparin or LMWH</li>\n<li>Contraindication to primary PCI or any excessive bleeding risk (e.g. recent surgery) or suspected active internal bleeding</li>\n<li>Coexistent condition associated with a limited life expectancy at short term (e.g. advanced cancer)</li>\n<li>Prolonged (&gt; 10 minutes) cardiopulmonary resuscitation (CPR)</li>\n<li>Treatment with other investigational agents or devices within the previous 30 days, planned use of investigational drugs or devices, or previous enrolment in this trial</li>\n</ol>\n</p>', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:a5b5c86ab927342057070e06ad69c32b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5a29a8883d4b5d75e4bf623534750e20' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>major bleeding during hospitalization [&nbsp;Time&nbsp;Frame:&nbsp;during hospitalization and at 6 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:5a29a8883d4b5d75e4bf623534750e20' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ae07784bb321ff8de1a2ea90c0d4368f' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>the ischemic end-point of death, reinfarction, refractory ischemia and/or urgent revascularization [&nbsp;Time&nbsp;Frame:&nbsp;day30 and 6 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:ae07784bb321ff8de1a2ea90c0d4368f' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9ae398aa5ee15bb02af4377ca95b51b3' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>the composite of major and minor bleeding during hospitalization [&nbsp;Time&nbsp;Frame:&nbsp;during hospitalization and months 6&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:9ae398aa5ee15bb02af4377ca95b51b3' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bede9aac65c302a2012a40f0d894ba74' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Comparison of two treatments of fibromyalgia; the QOL score should improve rather and, twelve months after the end of the program, remain higher in &quot;Plurifocal educational group&quot; than in control group</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:bede9aac65c302a2012a40f0d894ba74' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:23bd85fd4a6caad7c8a857d43597c07a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Evaluation of Improving Quality of Life of Fibromyalgia Patients Treated With a Plurifocal Program : a Controlled Study With 12 Months Monitoring.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:23bd85fd4a6caad7c8a857d43597c07a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3509c40b3de662417aaa9bf9083fc7db' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Comparing two forms of non-drug treatment of fibromyalgia: &quot;Information&quot; (an information group session on the fibromyalgia management modalities) versus &quot;Plurifocal educational program &quot; (intensive group program of 8 weeks, including, in addition to the briefing, measures and exercises for the implementation of the principles of managing fibromyalgia, and cognitive-behavioral therapy).</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:3509c40b3de662417aaa9bf9083fc7db' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bd6c084772c3f32668f40699e672100c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Fibromyalgia Patients according to the criteria of the American College of Rheumatology defined by:\n<ul>\n<li>diffuse pain evolving for over three months</li>\n<li>pain on palpation of at least 11 of the 18 sites listed</li>\n</ul>\n</li>\n<li>age between 18 and 65</li>\n<li>FIQ Score higher than 35/100 at inclusion</li>\n<li>Ability to respond to questionnaires</li>\n<li>monitoring possibility for at least a year</li>\n<li>Affiliation to the French Health System (social security)</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Association with chronic pain from other sources which can interfere with fibromyalgia assessment</li>\n<li>Inability to follow the full educational program</li>\n<li>previous participation in an educational program of same nature</li>\n<li>psychological disorder (personality disorder or behaviour, schizophrenia), preventing participation in the program group</li>\n</ul>\n</p>', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:bd6c084772c3f32668f40699e672100c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f45c397566775d286107fc3cfc5c629e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This prospective randomised study comparing administration of a hypo-osmolar oral hydration solution with the classical hydration via IV (intravenous) infusion in premature infants of more than 32 weeks GA (gestational age) aims to determine whether administration of a hypo-osmolar oral hydration solution is as efficient as intravenous infusion.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:f45c397566775d286107fc3cfc5c629e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:26c3f3119c59aee6a51e93bf295a81b1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Weight, length, head circumference and brachial circumference [&nbsp;Time&nbsp;Frame:&nbsp;day 3, 15 of life, and at 37 GA.&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:26c3f3119c59aee6a51e93bf295a81b1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ccbd682e28b7794914eaa2c80c63d95c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Weight, Height/length, head circumference and brachial circumference [&nbsp;Time&nbsp;Frame:&nbsp;6 and 12 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:ccbd682e28b7794914eaa2c80c63d95c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8e1e45807563b7d84f114b387582e021' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>pathologic digestive diseases (enteropathy, NEC&#8230;) [&nbsp;Time&nbsp;Frame:&nbsp;J0 to J16&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:8e1e45807563b7d84f114b387582e021' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c621cb729c21078f440e12fdefc17e6b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>pain and discomfort score (EDIN) evaluated 3 times a day [&nbsp;Time&nbsp;Frame:&nbsp;Day 0 to day 16&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:c621cb729c21078f440e12fdefc17e6b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4cb693757ffcf20f119f4448c927f9de' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>secondary IV infusion effects [&nbsp;Time&nbsp;Frame:&nbsp;Day 0 to day 8&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:4cb693757ffcf20f119f4448c927f9de' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:157a9a9f9889f5fb96c2565d9d7fe80e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>number of failure to pick and to perfuse a baby [&nbsp;Time&nbsp;Frame:&nbsp;Day 0 to day 8&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:157a9a9f9889f5fb96c2565d9d7fe80e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c5d73ec0391792a45c9311168feeb958' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>ORS culture [&nbsp;Time&nbsp;Frame:&nbsp;in case of infection&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:c5d73ec0391792a45c9311168feeb958' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:95b7a8f13decd9fa497c6fa886fc455d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Adverse Events [&nbsp;Time&nbsp;Frame:&nbsp;Up to 12 months&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:95b7a8f13decd9fa497c6fa886fc455d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fb1aab9d50790d68b8549ca1bca9481d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>In order to avoid to use a traumatic and iatrogenic examen (phlebography), the purpose of the study is to validate echography doppler in the diagnosis of asymptomatic related catheter related thrombosis.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:fb1aab9d50790d68b8549ca1bca9481d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c6010b0094a4c0a44adf2750bf375b36' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>CAVECCAS Value of Risk Factors for Symptomatic Catheter Related Thrombosis in Patients With Breast Cancer Treated With Adjuvant Chemotherapy</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:c6010b0094a4c0a44adf2750bf375b36' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:be5ae1f4bd0666057710e8297f572c72' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Phlebography is the gold standard for the diagnosis of asymptomatic catheter related thrombosis but can not be performed in about 15% of patients because of arm swelling and lack of superficial veins. Echography doppler is an easy, cheap and atraumatic way to make the diagnosis of deep vein thrombosis. The value of echography doppler has been proven for the diagnosis of symptomatic deep venous thrombosis of lower and upper limbs and for the diagnosis of proximal asymptomatic lower limbs. To validate the echography doppler we intend to correlate asymptomatic findings to the occurrence symptomatic related catheter related thrombosis. Patients with localized breast cancer treated with chemotherapy will be enrolled in the study. An echography doppler will be performed on day 8, 30 and 90 after catheter insertion. Findings in asymptomatic patients (thrombus visualisation, lack of vein compressibility, variation of physiologic vein blood flow) will thereafter be correlated with the presence or absence of clinical signs of catheter related thrombosis. In order to assess if they are risk factors for catheter related thrombosis, we will determine the level D-Dimer, microparticles and the results of generation thrombin tests before and 2 days after catheter insertion.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:be5ae1f4bd0666057710e8297f572c72' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:44f726e615402fa1ead4e6e1cc85a18d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>women over 18</li>\n<li>histologically proven breast cancer</li>\n<li>localized breast cancer without metastasis</li>\n<li>adjuvant or neo adjuvant chemotherapy</li>\n<li>insertion of central catheter with port for chemotherapy</li>\n<li>central catheter for more than three months</li>\n<li>inform consent</li>\n<li>follow up for three months</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>ongoing anticoagulant therapy</li>\n<li>previous central catheter</li>\n<li>femoral catheter</li>\n<li>double lumen catheter</li>\n<li>central catheter without port</li>\n<li>platelets &lt; 80G/L, TQ &lt; 50%, fibrinogen &lt; 1 g/L</li>\n<li>creatinin &gt; 175mole/L</li>\n</ul>\n</p>', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:44f726e615402fa1ead4e6e1cc85a18d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0454f86d9b08db97df41367340a6b301' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The aim of this study is to evaluate the effects of a supplementation of citrulline for three weeks in elderly malnourished and hospitalised subjects on muscle protein synthesis.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:0454f86d9b08db97df41367340a6b301' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7cfa3205ad53603011161d6c1f722771' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Citrulline Supplementation in Elderly Malnourished and Hospitalised Subjects: Effects on Protein Metabolism</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:7cfa3205ad53603011161d6c1f722771' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:65d1c5afdfaea8b51a159e19b93c69e9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Malnutrition in the elderly causes an important public health problem because their response to re nutrition is highly decreased. Several experimental studies have shown that an amino acid named citrulline could avoid this, by restoring protein synthesis. The treated group will receive each morning for three weeks a supplementation of 10 g of citrulline and the control group, non essential amino acids in iso-nitrogenous quantity to the 10g of citrulline. During the three weeks of supplementation, clinical tolerance and physical exercise will be evaluated regularly. On the 21st day, whole body protein synthesis rate in the post-absorptive state will be measured by the isotopic dilution of L-leucine (1-13C expressed in g / kg of lean mass / 24h) as well as other parameters of the protein turn-over in the post-absorptive and post-prandial state.</p>\n', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:65d1c5afdfaea8b51a159e19b93c69e9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:91225a55d757d28ca72df58af9b1b398' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>elderly hospitalised in geriatric medicine or in following care and rehabilitation, moderately malnourished</li>\n<li>aged more than 70 years</li>\n<li>recent moderate undernutrition (30 g/l &lt; albuminemia &lt; 35 g/l and 18 &lt; BMI &lt; 22 or a score of the MNA &lt; 17 with albuminemia &gt; 30 g/l)</li>\n<li>ingesta of at least 20 kcal / kg / d and 0,8 g / kg / d of proteins</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>hospitalisation &lt; 21d</li>\n<li>CRP &gt; 50 mg / l</li>\n<li>end-stage cardiac insufficiency</li>\n<li>severe digestive incapacity</li>\n<li>renal insufficiency (Creatinine Clearance &lt; 30 ml / mn)</li>\n<li>respiratory failure</li>\n<li>MMS &lt; 18</li>\n<li>uncontrolled acute or chronic infectious pathology (HIV, tuberculosis)</li>\n<li>corticoids treatment</li>\n<li>evolutionary neoplasia</li>\n<li>palliative phase of severe pathology</li>\n<li>Mental Mini Score status of Folstein (MMS) &lt; 8</li>\n<li>parenteral nutrition</li>\n<li>active chronic hepatitis or cirrhosis</li>\n<li>participation in another trial</li>\n</ul>\n</p>', created = 1283939162, expire = 1284025562, headers = '', serialized = 0 WHERE cid = '1:91225a55d757d28ca72df58af9b1b398' in /persistent/html/includes/cache.inc on line 109.

Impact of OncoDoc2 on Guideline Compliance in the Management of Breast Cancer

Recruitment status: 
Recruiting

The objective of the study is to evaluate how the use of OncoDoc2, a computerized guideline-based decision support system, could improve the compliance of multidisciplinary staff meeting decisions with local clinical practice guidelines in the management of non-metastatic breast cancer.

Background information
Trial ID: 
NCT00728442
Other unique IDs: 
K 070603
Official title: 

Impact of the OncoDoc2 Decision Support System on Compliance of Multidisciplinary Staff Meeting Decisions With Clinical Practice Guidelines in the Management of Non-Metastatic Breast Cancer.

Detailed description: 

In France, to promote the quality of cancer care, decisions have currently to be made according to clinical practice guidelines (CPGs) during regularly organized multidisciplinary staff meetings (MSMs). Dissemination of textual CPGs has a poor impact on clinical practice as opposed to the use of clinical decision support systems (CDSSs) known to improve compliance with CPGs.

Number to be enrolled: 
354 patients
Acronym: 
OncoDoc2

Protective Effect of Mangafodipir Against Oxaliplatin Neurotoxicity

Trial phase: 
Phase II
Recruitment status: 
Recruiting

Oxaliplatin is a major antitumor agent but its use is limited by potentially disabling neurotoxicity, characterized by a sensitive defect in the extremities.Mangafodipir is a MRI contrast agent with antioxidant properties. Our previous laboratory works showed that mangafodipir is able to prevent hematologic toxicity of several chemotherapy agents, including oxaliplatin and to increase their antitumor activity. Preliminary clinical data suggested that mangafodipir could prevent oxaliplatin neurotoxicity.The primary purpose of the present study is to assess the protective effect of mangafodipir in patients who have a already moderate oxaliplatin neuropathy and in whom the continuation of this treatment is desirable because of significant antitumor effect.

Background information
Trial ID: 
NCT00727922
Other unique IDs: 
P071203
MnDPDP04
IDRCB 2008-A000198-39
Official title: 

Evaluation of Mangafodipir Protective Activity Against Oxaliplatin Neurotoxicity

Detailed description: 

Phase 2 study aiming to assess the protective effect of mangafodipir against the oxaliplatine neuropathy.Population: Cancer patient who have a mild (grade 2) oxaliplatin neuropathy and in whom the continuation of oxaliplatin for at least 4 infusions is desirable will be include, whatever the location of the primitive tumor and the use of others anticancer agents.Treatment: Mangafodipir (0.5 ml/kg) is administered as a 30 minutes infusion just after each administration of oxaliplatin.

Number to be enrolled: 
25 patients
Acronym: 
MnDPDP-K04

ARTHRO Distension Plus Intensive Mobilisation in Shoulder Capsulitis

Trial phase: 
Phase III
Recruitment status: 
Not yet recruiting

The purpose of this study is to evaluate the effectiveness of ARTHRO distension plus intensive mobilisation in shoulder capsulitis.

Background information
Trial ID: 
NCT00724113
Other unique IDs: 
P051039
Official title: 

Evaluation of the Effectiveness of ARTHRO -Distension Plus Intensive Mobilisation in Shoulder Capsulitis

Detailed description: 

The aim of the study is to evaluate a treatment of shoulder capsulitis that associates ARTHRO distension and intensive mobilisation at 2, 6, 12, 26 and 52 weeks. It is a bicentric 48-month (inclusion: 36 months; follow up: 12 months) observer blind randomised clinical trial using 2 groups in parallel. The number of patients to be included is 58. The treatment that is evaluated associates ARTHRO distension followed by mobilisation of the shoulder 6 hours per day during 5 days, and then sessions of physiotherapy for 4 weeks.

Number to be enrolled: 
58 patients
Acronym: 
CAPSULITE

Surgical Treatment for Morbid Obesity by Sleeve Gastrectomy Versus Gastric Bypass

Recruitment status: 
Recruiting

The aim of this study is to assess that the sleeve gastrectomy can improve the risk benefit than the gastric bypass

Background information
Trial ID: 
NCT00722995
Other unique IDs: 
K060213
IDRCB2007-A00373-50
Official title: 

Surgical Treatment for Morbid Obesity by Sleeve Gastrectomy Versus Gastric Bypass Randomised Study Comparing Complications, Efficacy and Quality of Life

Detailed description: 

In the obese patient population, the frequency of patients presenting a severe morbid obesity (45 >= BMI <= 50), a super obesity (BMI >50), a super super obesity (BMI>60), and obese patients (BMI>40) with a failure of gastric banding is constantly increasing. In these patients, the surgery risk is proportionate to the weight and / or gastric surgery records. This risk is high, in bariatric surgery, for gastric bypass procedure.

Number to be enrolled: 
280 patients
Acronym: 
SLEEVE

Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin)

The purpose of this study is to test the effectiveness of an antibiotic treatment (Josamycin) in the case of positive PCR for Ureaplasma spp. and/or Mycoplasma hominis in the second quarter on the risk of premature birth.

Background information
Other unique IDs: 
P060216
AOM 06046

STEMI Treated With Primary Angioplasty and Intravenous Lovenox or Unfractionated Heparin (UFH)

Trial phase: 
Phase III
Recruitment status: 
Recruiting

Randomized evaluation of enoxaparin (0.5mg/kg IV) versus UFH (50-70IU/kg with GPIIb/IIIa inhibitors; 70-100IU without GPIIb/IIIa inhibitors). Anticoagulation can be continued after the procedure using the same agents as those allocated per randomization (enoxaparin SC, UHF IV or SC)

Background information
Trial ID: 
NCT00718471
Other unique IDs: 
P071101
EUDRACT: 2007-007676-42
Official title: 

Acute STEMI Treated With Primary Angioplasty and Intravenous 0.5 mg/kg Lovenox or UFH to Lower Ischemic and Bleeding Events

Detailed description: 

This study is a prospective, multicenter, multinational, randomized, active-control arm trial. The study population consists of subjects with ST-segment elevation MI who are randomized within 24 hours of symptom onset. Subjects presenting between 12 and 24 hours of symptom onset should present with recurrent or persisting chest pain and/or recurrent or persisting ST elevation suggesting ongoing ischemia, and an indication of primary PCI. Approximately 850 subjects will be enrolled at approximately 50 sites in several countries including Austria, France, Germany and the United States.

Number to be enrolled: 
850 patients
Acronym: 
ATOLL

Improving Quality of Life of Fibromyalgia Patients

Recruitment status: 
Recruiting

Comparison of two treatments of fibromyalgia; the QOL score should improve rather and, twelve months after the end of the program, remain higher in "Plurifocal educational group" than in control group

Background information
Trial ID: 
NCT00715195
Other unique IDs: 
AOR05005
P051029
Official title: 

Evaluation of Improving Quality of Life of Fibromyalgia Patients Treated With a Plurifocal Program : a Controlled Study With 12 Months Monitoring.

Detailed description: 

Comparing two forms of non-drug treatment of fibromyalgia: "Information" (an information group session on the fibromyalgia management modalities) versus "Plurifocal educational program " (intensive group program of 8 weeks, including, in addition to the briefing, measures and exercises for the implementation of the principles of managing fibromyalgia, and cognitive-behavioral therapy).

Number to be enrolled: 
100 patients
Acronym: 
Aquavip

Oral Versus Intravenous Rehydration for Prevention of Dehydration in Premature Babies, During the First Days of Life.

This prospective randomised study comparing administration of a hypo-osmolar oral hydration solution with the classical hydration via IV (intravenous) infusion in premature infants of more than 32 weeks GA (gestational age) aims to determine whether administration of a hypo-osmolar oral hydration solution is as efficient as intravenous infusion.

Background information
Other unique IDs: 
P060208

Determination of Predictive Value of Echography Doppler Abnormalities

Recruitment status: 
Recruiting

In order to avoid to use a traumatic and iatrogenic examen (phlebography), the purpose of the study is to validate echography doppler in the diagnosis of asymptomatic related catheter related thrombosis.

Background information
Trial ID: 
NCT00714909
Other unique IDs: 
K070104
N° ID RCB: 2007-A01123-50
Official title: 

CAVECCAS Value of Risk Factors for Symptomatic Catheter Related Thrombosis in Patients With Breast Cancer Treated With Adjuvant Chemotherapy

Detailed description: 

Phlebography is the gold standard for the diagnosis of asymptomatic catheter related thrombosis but can not be performed in about 15% of patients because of arm swelling and lack of superficial veins. Echography doppler is an easy, cheap and atraumatic way to make the diagnosis of deep vein thrombosis. The value of echography doppler has been proven for the diagnosis of symptomatic deep venous thrombosis of lower and upper limbs and for the diagnosis of proximal asymptomatic lower limbs.

Number to be enrolled: 
600 patients
Acronym: 
CAVECCAS

Citrulline and Protein Metabolism in the Malnourished Elderly People

Recruitment status: 
Not yet recruiting

The aim of this study is to evaluate the effects of a supplementation of citrulline for three weeks in elderly malnourished and hospitalised subjects on muscle protein synthesis.

Background information
Trial ID: 
NCT00714675
Other unique IDs: 
P070127
Official title: 

Citrulline Supplementation in Elderly Malnourished and Hospitalised Subjects: Effects on Protein Metabolism

Detailed description: 

Malnutrition in the elderly causes an important public health problem because their response to re nutrition is highly decreased. Several experimental studies have shown that an amino acid named citrulline could avoid this, by restoring protein synthesis. The treated group will receive each morning for three weeks a supplementation of 10 g of citrulline and the control group, non essential amino acids in iso-nitrogenous quantity to the 10g of citrulline. During the three weeks of supplementation, clinical tolerance and physical exercise will be evaluated regularly.

Number to be enrolled: 
30 patients
Acronym: 
CIPROAGE
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