Unspecified Adult Solid Tumor, Protocol Specific

  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:bca30b43085acc1255bde5476a39ad6c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Aerobic exercise may help prevent side effects caused by chemotherapy and help improve heart health. PURPOSE: This randomized clinical trial is studying the side effects of aerobic exercise and to see how well it works in patients receiving chemotherapy for cancer.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:bca30b43085acc1255bde5476a39ad6c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:305ec535ae4bfa5b64bd6be840671349' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>CCCWFU 99108 - Effect of Exercise Training in Patients Receiving Anthracycline Drugs - A Pilot Study</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:305ec535ae4bfa5b64bd6be840671349' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2787adf20983caee44d1ac380b290021' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES:\n<ul>\n<li>To determine if patients with cancer can exercise safely and routinely, under supervision, while receiving anthracycline chemotherapy.</li>\n<li>To determine the magnitude of the change in the peak ventilatory oxygen uptake (VO2) before and after completion of anthracycline chemotherapy with concurrent exercise versus without exercise in patients with cancer.</li>\n</ul>\n</p><p> OUTLINE: Patients are randomized to 1 of 2 intervention arms.\n<ul>\n<li>Arm I (exercise): Patients undergo supervised aerobic exercise (walk or bicycle) 3 days a week concurrently with standard anthracycline-based chemotherapy for approximately 18-24 weeks.</li>\n<li>Arm II (non-exercise): Patients receive standard anthracycline-based chemotherapy for approximately 18-24 weeks.</li>\n</ul>\n</p><p> Patients undergo peak ventilatory oxygen uptake (VO_2) by exercise bike test with gas exchange analysis at baseline and at 2 weeks after completion of anthracycline-based chemotherapy.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:2787adf20983caee44d1ac380b290021' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:55b5ec927ea50e6badcf08f5bf1630ab' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Patients with cancer scheduled to receive 4-6 courses of an anthracycline-based chemotherapy</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>Able to pedal a stationary bicycle</li>\n<li>No severe hypertension (systolic blood pressure &gt; 220 mm Hg or diastolic blood pressure &gt;120 mm Hg)</li>\n<li>No atrial fibrillation with an uncontrolled ventricular response</li>\n<li>No ventricular arrhythmias</li>\n<li>No unstable angina</li>\n<li>No acute myocardial infarction within the past 28 days of enrollment</li>\n<li>No severe valvular heart disease</li>\n<li>No severe (exercise-limiting) peripheral vascular disease</li>\n<li>No severe pulmonary disease</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n</ul>\n</p>', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:55b5ec927ea50e6badcf08f5bf1630ab' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b98daa01fb444118f438be1d93efa18d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage of patients enrolling in the study [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:b98daa01fb444118f438be1d93efa18d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e956c142a933fc9c309960797e15c0c7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage of patients completing the study [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:e956c142a933fc9c309960797e15c0c7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2d47e14359d47eefe979a6041fd83956' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Number and types of adverse events [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:2d47e14359d47eefe979a6041fd83956' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9178739fa3bbd768894159b21b081e08' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy regimen is more effective in treating metastatic spinal cord compression. PURPOSE: This randomized clinical trial is comparing two radiation therapy regimens to see how well they work in treating patients with metastatic spinal cord compression.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:9178739fa3bbd768894159b21b081e08' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1c66f8822c345a2fc0e967e8f954929b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>SCORAD: A Randomised Feasibility Study of Single Fraction Radiotherapy Compared to Multi-Fraction Radiotherapy in Patients With Metastatic Spinal Cord Compression</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:1c66f8822c345a2fc0e967e8f954929b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc724fc9b830ff6f6652a277b6642531' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES:\n<ul>\n<li>To examine whether a phase III randomized study comparing a single-fraction of radiotherapy with multi-fraction radiotherapy is acceptable to clinicians and to patients with metastatic spinal cord compression.</li>\n<li>To determine the feasibility of conducting this study in the United Kingdom.</li>\n</ul>\n</p><p> OUTLINE: This is a multicenter study. Patients are stratified by treatment center and known prognostic factors (ambulatory status at diagnosis, primary tumor type, and extent of disease [spinal metastases only vs spinal and non-bony metastases]). Patients are randomized to 1 of 2 treatment arms.\n<ul>\n<li>Arm I (multi-fraction radiotherapy): Patients undergo 5 fractions of 20 Gy external-beam radiotherapy.</li>\n<li>Arm II (single-fraction radiotherapy): Patients undergo 1 fraction of 8 Gy external beam radiotherapy.</li>\n</ul>\n</p><p> Patients undergo assessment of ambulatory status, quality of life, bladder and bowel function, and acute toxicity via self-reported questionnaires and telephone follow-ups at baseline and weeks 1, 4, 8, and 12.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:cc724fc9b830ff6f6652a277b6642531' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d336c1f03437edaaf3a9c2bc10c68a8b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically or cytologically confirmed malignant disease</li>\n<li>Proven diagnosis of metastatic spinal cord compression on MRI or CT scan\n<ul>\n<li>Single site of compression OR multiple sites that can be treated within a single radiation treatment field</li>\n</ul>\n</li>\n<li>No patient for whom surgery or chemotherapy treatment is more appropriate</li>\n<li>No multiple myeloma as primary cancer</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>Life expectancy &gt; 1 month</li>\n<li>Not pregnant</li>\n<li>Willing and able to complete assessment forms</li>\n<li>Able to give informed consent</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n</ul>\n</p>', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:d336c1f03437edaaf3a9c2bc10c68a8b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6dd4d39e6eb9c8b8e58ffc747c879ce0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Ambulatory status at 1, 4, 8, and 12 weeks from day 1 of treatment compared to baseline [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:6dd4d39e6eb9c8b8e58ffc747c879ce0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1487974dc343c5d2f697ae892bb05129' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Bladder and bowel function at 1, 4, 8, and 12 weeks from day 1 of treatment compared to baseline [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:1487974dc343c5d2f697ae892bb05129' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:309af14153e9b3ad3d40d05adfb278b1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Acute side effects using RTOG scales at 1, 4, 8, and 12 weeks from day 1 of treatment [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:309af14153e9b3ad3d40d05adfb278b1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:43c63dee9db238f5a21d61532d18ce35' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Quality of life as measured by the EORTC QLQ-C30 questionnaire at 1, 4, 8, and 12 weeks from day 1 of treatment compared to baseline [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:43c63dee9db238f5a21d61532d18ce35' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d429f12a7286ea8d39cc2c50e5149228' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Further treatment [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:d429f12a7286ea8d39cc2c50e5149228' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:64b4cd47b7e4a3f2e64c859aa100c4e7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Overall survival at 3, 6, and 12 months [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:64b4cd47b7e4a3f2e64c859aa100c4e7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b335273f9eff422e77528862c137b1eb' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Total number of days spent in hospital [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:b335273f9eff422e77528862c137b1eb' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6b9f4373487cbbccad6c7ec0f9150f6a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Preferred place of care [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:6b9f4373487cbbccad6c7ec0f9150f6a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ddabe8115c73654816bbe3ae17ddbc1a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Number of patients eligible but not randomized and reasons for non-randomization [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:ddabe8115c73654816bbe3ae17ddbc1a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:83093853389028cd1080b0720e1d5b9d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:83093853389028cd1080b0720e1d5b9d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e682a05167afedd5b7847872f75934f5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Randomized Comparison of Oral Methadone as a &quot;First-Switch&quot; Opioid Versus Opioid Switching Between Sustained-Release Morphine and Oxycodone for Oncology-Hematology Outpatients With Pain Management Problems: The &quot;Simply Rotate&quot; Study</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:e682a05167afedd5b7847872f75934f5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:76802cc08dc38182f705aec18b74013c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES: Primary\n<ul>\n<li>To compare the effectiveness of an opioid rotation to oral methadone versus an opioid rotation to another long-acting strong opioid (sustained-release morphine or oxycodone) in controlling pain (i.e., analgesia) in patients with cancer.</li>\n</ul>\n</p><p> Secondary\n<ul>\n<li>To compare the tolerability of an opioid rotation to oral methadone versus an opioid rotation to another long-acting strong opioid (sustained-release morphine or oxycodone).</li>\n<li>To identify a subset of patients most likely to benefit from an opioid rotation to oral methadone, in terms of significant improvement in pain control or opioid tolerability.</li>\n</ul>\n</p><p> OUTLINE: This is a multicenter study. Patients are stratified according to their baseline opioid (morphine vs oxycodone). Patients are randomized to 1 of 2 treatment arms.\n<ul>\n<li>Arm I: Patients are switched from their current opioid medication (oxycodone or morphine) to methadone. Patients receive oral methadone 2-3 times daily for 4 weeks.</li>\n<li>Arm II: Patients currently receiving oxycodone are switched to sustained-release (SR) morphine. Patients currently receiving morphine are switched to SR oxycodone. Patients receive either oral SR morphine or oxycodone 2-3 times daily for 4 weeks.</li>\n</ul>\n</p><p> Patients are assessed for pain control and complete a symptom questionnaire on days 1, 8, 15, 22, and 28.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:76802cc08dc38182f705aec18b74013c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b46412cca3c03de4baffb656fd8990bb' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Receiving ongoing care in the outpatient medical oncology setting</li>\n<li>Self-reported pain (of any cause) for which long-acting strong opioids (morphine or oxycodone) have been prescribed or administered\n<ul>\n<li>Oral morphine-equivalent daily dose (MEDD) of existing opioid regimen (long-acting or immediate-release) 40-300 mg/day</li>\n</ul>\n</li>\n<li>Worst pain score on a scale of 0 (no pain) to 10 (worst pain) of &#8805; 5 for &#8805; 1 week duration based on verbal self-report AND/OR &#8805; 1 persistently bothersome symptom attributed to an opioid side effect (e.g., fatigue, confusion, depressed level of consciousness, memory loss, personality change, anorexia, constipation, dehydration, nausea, vomiting, weight loss, pruritus, urticaria, impotence, reduced libido, and urinary retention or hesitancy)</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>None of the following conditions that could predispose the patient to prolonged QT interval-associated tachycardia:\n<ul>\n<li>Serum potassium &lt; 3.0 mg/dL</li>\n<li>Cocaine abuse within the past 3 months</li>\n<li>Family history of sudden death</li>\n<li>Advanced heart failure (ejection fraction &lt; 40% and/or NYHA class III or IV heart disease)</li>\n</ul>\n</li>\n<li>No known or suspected cognitive impairment that could interfere with adherence to the medication plan or self-report of symptoms and side effects</li>\n<li>Not pregnant or nursing</li>\n<li>Fertile patients must use effective contraception</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>More than 4 weeks since prior radiotherapy or surgery for local control of cancer or pain palliation</li>\n<li>More than 60 days since prior use of the same long-acting opioid (i.e., the new long-acting opioid) that patient is switching to on the study</li>\n<li>More than 12 weeks since prior methadone therapy</li>\n<li>More than 3 days since prior and no concurrent transdermal fentanyl, oxymorphone, or buprenorphine</li>\n<li>Concurrent systemic anticancer therapy or bisphosphonates allowed provided therapy was initiated &#8805; 4 weeks ago</li>\n<li>Concurrent tricyclic antidepressants, NSAIDs, anticonvulsants, or other adjuvant analgesics or psychostimulants allowed provided therapy was initiated &#8805; 2 weeks ago\n<ul>\n<li>Dose expected to remain stable until after the first week of opioid rotation on study</li>\n</ul>\n</li>\n<li>No concurrent methadone maintenance therapy for opioid addiction</li>\n<li>No concurrent intrathecal infusion of analgesics</li>\n<li>No concurrent antiarrhythmic medications (e.g., amiodarone or quinidine)</li>\n</ul>\n</p>', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:b46412cca3c03de4baffb656fd8990bb' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:16e9ff6530662c4e767ab2cbf540d2e9' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>30% reduction in patients\' total summary score for the individual composite drug toxicity score (CDTS) items [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:16e9ff6530662c4e767ab2cbf540d2e9' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a745fbf8b3911431b7c93870d4965fdf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Identification of a subset of patients most likely to benefit from an opioid rotation to oral methadone, in terms of significant improvement in pain control or opioid tolerability [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:a745fbf8b3911431b7c93870d4965fdf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2642f3e998843caf0b2c0fc70e2307b8' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Sirolimus may stop the growth of abnormal cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well sirolimus works in treating patients with Cowden syndrome or another germline mutation syndrome.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:2642f3e998843caf0b2c0fc70e2307b8' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:be7cf51df829a24e2f650c15f8adb43d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Biochemical changes (i.e., inhibition of the mTOR pathway) in peripheral blood mononuclear cells as assessed by immunoblotting [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:be7cf51df829a24e2f650c15f8adb43d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4225a839b086f3c9c3a97e6bd2eac591' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Changes in tumor size and duration of change as assessed by CT scan, digital photography, and digital dermoscopy [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:4225a839b086f3c9c3a97e6bd2eac591' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d3d8432604907275ca0937643e453265' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Changes in tumor metabolism as assessed by PET scan [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:d3d8432604907275ca0937643e453265' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9266be3bf82601dfcba9b23df0331fdf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Changes in lymphocyte counts [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:9266be3bf82601dfcba9b23df0331fdf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:185129916b60e3f800b86464f1910050' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: American ginseng may reduce fatigue in patients with cancer. It is not yet known whether American ginseng is more effective than a placebo in treating cancer-related fatigue. PURPOSE: This randomized phase III trial is studying American ginseng to see how well it works in treating patients with fatigue caused by cancer.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:185129916b60e3f800b86464f1910050' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6e3195a0a1c531f2c83403ad8eddd2cf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Toxicities [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:6e3195a0a1c531f2c83403ad8eddd2cf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0abbed8980d36b283c3f4bde494a3e61' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Impact on physical, mental, and emotional states and vigor as measured by other subscales of the MFSI-SF and BFI [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:0abbed8980d36b283c3f4bde494a3e61' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:554f38043d3ac266ea2f71ac1dce07d6' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Fatigue as measured by the BFI and Linear Analogue Scale Fatigue [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:554f38043d3ac266ea2f71ac1dce07d6' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5ed3bd456d02aec60b46680b0cc4bc04' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Fatigue-inertia, vigor-activity, tension-anxiety, anger-hostility, and confusion-bewilderment as measured by POMS and subscales of the MFSI-SF [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:5ed3bd456d02aec60b46680b0cc4bc04' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:468edc2f3a8b61efea3d652231d56885' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Impact on stress/fatigue as measured by Perceived Stress Scale [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:468edc2f3a8b61efea3d652231d56885' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9707e747feac0d2459c10c45235736d6' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Efficacy on fatigue in minority populations [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:9707e747feac0d2459c10c45235736d6' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:eedd2ab1d6bd6b6c45c06f9f6c1d1e90' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Impact of Wisconsin Ginseng on the expression of cortisol and cytokine in fatigued cancer survivors [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:eedd2ab1d6bd6b6c45c06f9f6c1d1e90' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:79a9195d9d2f2472c37e9f02ad13c14b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Role of cortisol and cytokine changes as the mechanism by which Wisconsin Ginseng can ameliorate cancer related fatigue [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:79a9195d9d2f2472c37e9f02ad13c14b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8f9e1735504ba32f7845621b1da696c0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Relationships between cytokine and cortisol levels with secondary outcomes such as mood and stress [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:8f9e1735504ba32f7845621b1da696c0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c4ce7bf0a4965c2fbfd489f248ad1ba1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Drugs used in chemotherapy, such as hydroxychloroquine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of hydroxychloroquine when given together with temozolomide in treating patients with metastatic or unresectable solid tumors.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:c4ce7bf0a4965c2fbfd489f248ad1ba1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c20121ead2a260ac7816252ff860bae0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Toxicity rates [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:c20121ead2a260ac7816252ff860bae0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:feaf7a89ca5559a2b09165e60be44219' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Pharmacodynamic and pharmacokinetic correlative endpoints [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:feaf7a89ca5559a2b09165e60be44219' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b283bf76c791e4722a669f841e56e71c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Morphine may reduce pain in patients who have undergone radiofrequency ablation to remove bone metastases. PURPOSE: This phase II trial is studying how well morphine works after radiofrequency ablation of painful bone metastases in patients with cancer.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:b283bf76c791e4722a669f841e56e71c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:24459324781f014c2b601961cd961b56' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Evaluation of the Effectiveness of the Radiofrequency Ablation for Reducing Refractory Pain From Bone Metastases</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:24459324781f014c2b601961cd961b56' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7c91e4349a117d2b77346355b7b593c2' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES: Primary\n<ul>\n<li>Measure the efficacy of morphine sulfate at 8 weeks after radiofrequency ablation (RFA) of bone metastases.</li>\n</ul>\n</p><p> Secondary\n<ul>\n<li>Assess minimum and average pain and analyze use of morphine sulfate before and after RFA.</li>\n<li>Determine disease progression by CT scan of bone.</li>\n<li>Evaluate the percentage of relief associated with RFA, specifically patient satisfaction, quality of life, anxiety, depression, and physical performance during RFA.</li>\n<li>Assess complications and side effects related to RFA and the evolution of possible side effects associated with morphine sulfate therapy.</li>\n</ul>\n</p><p> OUTLINE: This is a multicenter study. Patients complete a pain questionnaire over 1 week before undergoing radiofrequency ablation (RFA). Patients also complete questionnaires about pain, physical performance, quality of life (QOL), and anxiety at baseline. Bone metastases are removed by radiofrequency ablation (RFA). After surgery, patients receive acetaminophen and patient-controlled analgesic (PCA) morphine sulfate. PCA morphine sulfate continues with a dose increase of 50% bolus every 24 hours. Patients with maximum pain less than or equal to that at inclusion receive standard morphine sulfate therapy instead. Data concerning the total dose of PCA morphine sulfate; minimum, average, and maximum pain intensity; side effects and complications of RFA; and total dose of morphine sulfate (or equivalent) is collected daily. Pain is assessed at 4 and 8 weeks after RFA. Patients complete follow-up questionnaires about physical performance, QOL, and anxiety at 12 weeks. Patients also undergo a CT scan at 12 weeks.</p>\n', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:7c91e4349a117d2b77346355b7b593c2' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0a437945125c7077835ae9c5000a90bf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed cancer\n<ul>\n<li>Primary or unknown origin</li>\n</ul>\n</li>\n<li>Painful bone metastases despite radiotherapy or symptomatic relapse into previously irradiated area with no possibility of repeating radiotherapy\n<ul>\n<li>Bone metastases may have been treated with bisphosphonates</li>\n<li>Osteolytic bone or joint (lytic and condensed) confirmed by CT scan and meeting the following criteria:\n<ul>\n<li>Lesion size &#8804; 5 cm</li>\n<li>No more than 2 painful bone metastases\n<ul>\n<li>If 2 lesions are to be treated, distinct anatomical locations can be treated at the same time</li>\n</ul>\n</li>\n<li>Metastatic bone lesions of the pelvis, sacrum (in absence of canal involvement), ribs, or long bones allowed</li>\n</ul>\n</li>\n<li>Pain located at the tumor or in the area</li>\n</ul>\n</li>\n<li>Maximum pain in the last 24 hours &gt; 4 points (numerical scale to 11 points)</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>Life expectancy &gt; 3 months</li>\n<li>Platelet count &gt; 50,000/&#956;L</li>\n<li>Prothrombin &lt; 50%</li>\n<li>Activated cephalin time &#8804; 1.5 times normal</li>\n<li>Not pregnant</li>\n<li>Fertile patients must use effective contraception</li>\n<li>No geographical, social, or psychiatric reason that would preclude follow up</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>At least 4 weeks since prior radiotherapy</li>\n<li>At least 3 weeks since prior chemotherapy or bisphosphonates</li>\n<li>At least 1 week since beginning new painkiller therapy or anticoagulation treatment</li>\n<li>More than 30 days since participation in another drug study</li>\n<li>More than 30 days since prior surgery</li>\n</ul>\n</p>', created = 1283570779, expire = 1283657179, headers = '', serialized = 0 WHERE cid = '1:0a437945125c7077835ae9c5000a90bf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fb27004e34948cacdfd8421c97ff2898' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Drugs used in chemotherapy, such as docetaxel, oxaliplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of docetaxel when given with oxaliplatin and fluorouracil and to see how well they work in treating patients with metastatic or unresectable stomach cancer, gastroesophageal junction cancer, or other solid tumor.</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:fb27004e34948cacdfd8421c97ff2898' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:629df973dc2683337d531c01ec5a2033' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase I/II Study of Taxotere, Oxaliplatin, and 5- Fluorouracil</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:629df973dc2683337d531c01ec5a2033' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3e762b533d19d688f61dff1f683f9897' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES: Primary\n<ul>\n<li>To establish the maximum tolerated dose of docetaxel when administered with oxaliplatin and fluorouracil in patients with metastatic or unresectable solid tumors. (Phase I)</li>\n<li>To determine the response rate in patients with metastatic or unresectable adenocarcinoma of the stomach or gastroesophageal junction treated with this regimen. (Phase II)</li>\n</ul>\n</p><p> Secondary\n<ul>\n<li>To determine the dose limiting toxicity of this regimen in these patients.</li>\n<li>To evaluate the frequency of CYP3A4, CYP3A5, and MDR polymorphisms and their impact on toxicity of docetaxel.</li>\n<li>To evaluate the frequency of XRCC1 and ERCC2 polymorphisms and their impact on the toxicity of oxaliplatin.</li>\n<li>To evaluate the frequency of DPD and TSER polymorphisms and their impact on the toxicity of fluorouracil.</li>\n<li>To characterize the toxicity profile of this regimen in these patients.</li>\n</ul>\n</p><p> OUTLINE: This is a dose-escalation study of docetaxel. Patients receive docetaxel IV over 1 hour and oxaliplatin IV over 2 hours on day 1 and fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 14 days for at least 2 courses in the absence of disease progression, symptomatic tumor progression, or unacceptable toxicity. Patients undergo blood sample collection periodically for pharmacokinetic and pharmacogenomic correlative studies. Plasma concentrations of docetaxel are analyzed by reverse-phase high performance liquid chromatography and tandem mass spectrometry. Polymorphisms in CYP3A4/5, MDR, and other genes are analyzed by PCR. After completion of study therapy, patients are followed every 3 months. PROJECTED ACCRUAL: A total of 73 patients (30 for phase I and 43 for phase II) will be accrued for this study.</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:3e762b533d19d688f61dff1f683f9897' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cfe76dc1a11603bd5bc2c7f2d4997372' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed metastatic or surgically unresectable solid tumor meeting 1 of the following criteria:\n<ul>\n<li>Any solid tumor (Phase I)</li>\n<li>Adenocarcinoma of the stomach or gastroesophageal junction (Phase II)</li>\n</ul>\n</li>\n<li>Unidimensionally measurable disease by CT scan or MRI</li>\n<li>No uncontrolled brain metastasis</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>ECOG performance status 0-1</li>\n<li>ANC &#8805; 1,500/mm&#179;</li>\n<li>Platelet count &#8805; 100,000/mm&#179;</li>\n<li>Hemoglobin &#8805; 8.0 g/dL</li>\n<li>Creatinine &#8804; 1.5 times upper limit of normal (ULN)</li>\n<li>Total bilirubin normal</li>\n<li>Meets 1 of the following criteria:\n<ul>\n<li>Alkaline phosphatase (AP) normal AND AST or ALT &#8804; 5 times ULN</li>\n<li>AP &#8804; 2.5 times ULN AND AST or ALT &#8804; 1.5 times ULN</li>\n<li>AP &#8804; 5 times ULN AND AST or ALT normal</li>\n</ul>\n</li>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test</li>\n<li>Fertile patients must use effective contraception during and for &#8805; 3 months after completion of study therapy</li>\n<li>No preexisting neuropathy</li>\n<li>No concurrent uncontrolled illness or other condition that would preclude study compliance</li>\n<li>No history of severe hypersensitivity reaction to docetaxel or to other drugs formulated with polysorbate 80</li>\n<li>No history of allergic reactions attributed to compounds of similar chemical or biologic composition to agents used in this study</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>Recovered from prior therapy</li>\n<li>More than 4 weeks since prior therapy (Phase I)</li>\n<li>No prior oxaliplatin or taxanes (Phase I)</li>\n<li>More than 4 weeks since prior radiotherapy (Phase I)</li>\n<li>No more than two prior therapies for metastatic disease (Phase I)</li>\n<li>No prior therapy for metastatic disease (Phase II)</li>\n<li>At least 6 months since prior adjuvant therapy (given prior to the occurrence of metastatic disease) (Phase II)</li>\n<li>Prior fluorouracil and concurrent radiotherapy for palliation of the primary tumor allowed provided metastatic disease is present outside the radiotherapy field (Phase II)</li>\n<li>No prior radiotherapy to &#8805; 30% of bone marrow</li>\n<li>No other concurrent investigational agents</li>\n</ul>\n</p>', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:cfe76dc1a11603bd5bc2c7f2d4997372' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c2b34635505345fd1abd588af9af272e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Toxicity profile [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:c2b34635505345fd1abd588af9af272e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:313d5e8ab63735d05891634aba31280c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Maximum tolerated dose of docetaxel when given in combination with oxaliplatin and fluorouracil in patients with solid tumors (Phase I) [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:313d5e8ab63735d05891634aba31280c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5a3e6f454979fd726225d1c64ccbe492' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Response rate in patients with adenocarcinoma of the stomach or gastroesophageal junction (Phase II) [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:5a3e6f454979fd726225d1c64ccbe492' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6ebe77c2266651d73d0005151b1b5bdf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Dose-limiting toxicity of docetaxel when given in combination with oxaliplatin and fluorouracil [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:6ebe77c2266651d73d0005151b1b5bdf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:af2862a5ebdf520e0db32297c10a7ad0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of CYP3A4, CYP3A5, and MDR polymorphisms and their impact on docetaxel toxicity [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:af2862a5ebdf520e0db32297c10a7ad0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:423f49a02e0c07d8905d8f25a6fce325' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of XRCC1 and ERCC2 polymorphisms and their impact on oxaliplatin toxicity [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:423f49a02e0c07d8905d8f25a6fce325' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:789eebeb7636c688f69a45b69ae3dd6c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of DPD and TSER polymorphisms and their impact on fluorouracil toxicity [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:789eebeb7636c688f69a45b69ae3dd6c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ae2cd9b041f6290478cd549721322636' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Screening tests may identify people with cancer who are at high risk of losing weight and help doctors plan better treatment. PURPOSE: This clinical trial is studying how well a new screening tool works in predicting weight loss in patients with cancer.</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:ae2cd9b041f6290478cd549721322636' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4b400a91a432b5ee30334eafc105c9aa' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Predicting Weight Loss in People With Cancer: Development of a Screening Tool</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:4b400a91a432b5ee30334eafc105c9aa' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8763752eb0ff8a12dd1603eed8469628' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES:\n<ul>\n<li>To identify people with cancer who are at greatest risk of future weight loss by the development of a simple and practical screening tool.</li>\n<li>To estimate the reliability of the Appetite and Symptom Questionnaire (part 1).</li>\n<li>To develop a screening tool based on the ability of the optimal combination of items from the three measures (ASQ, MUST, CRP) to predict clinically significant weight loss over three months (part 2).</li>\n<li>To estimate the sensitivity and specificity at various cut-points of the developed screening tool in predicting clinically significant weight loss (&gt; 10% weight loss or between 5% and 10% weight loss with a BMI &lt; 20 kg/m^2) over three months (part 2).</li>\n</ul>\n</p><p> OUTLINE: This is a two-part study.\n<ul>\n<li>Part 1: Patients are asked to complete the Appetite and Symptom Questionnaire (ASQ) on two occasions, one week apart.</li>\n<li>Part 2: Patients are screened at baseline for risk of malnutrition using the Malnutrition Universal Screening Tool. Blood samples are also taken at this time to establish the level of C-reactive protein and patients complete the ASQ. Patients are weighed using calibrated scales and height measurements are obtained. Patients are asked about unplanned weight loss over the previous 3-6 months. Patients are weighed again at 3 months.</li>\n</ul>\n</p><p> Percentage weight loss is calculated at 3 months.</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:8763752eb0ff8a12dd1603eed8469628' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a5a446b212d18a6b29e00d0b61b20a72' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Meets 1 of the following criteria, depending on part of study:\n<ul>\n<li>Part 1:\n<ul>\n<li>Receiving radiotherapy for cancer at Nottingham City Hospital</li>\n<li>Likely to be clinically stable over the duration of one week (i.e., not at high risk of disease or treatment-related appetite and weight loss)</li>\n<li>Stable weight and appetite</li>\n</ul>\n</li>\n<li>Part 2:\n<ul>\n<li>Outpatient at Nottingham City Hospital with a confirmed diagnosis of primary lung or gastrointestinal cancer</li>\n<li>Lost no more than 10% of pre-illness stable body weight</li>\n<li>Lost no more than 5% of pre-illness stable body weight if body mass index (BMI) was less than 20 kg/m^2</li>\n<li>BMI &#8805; 18.5 kg/m^2</li>\n</ul>\n</li>\n</ul>\n</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>No condition impairing the ability to swallow</li>\n<li>Not receiving enteral tube feeding or parenteral nutrition (part 2)</li>\n<li>Able to be weighed (part 2)</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>No concurrent radiotherapy to the head, neck or upper gastrointestinal tract area</li>\n</ul>\n</p>', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:a5a446b212d18a6b29e00d0b61b20a72' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ce25cc4377e539d737fa4d1ee24c80e6' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Percentage weight loss by measuring height and weight at baseline and at 3 months [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:ce25cc4377e539d737fa4d1ee24c80e6' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:df0b208d081a7cdeb91b5ef34e633e8b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Malnutrition Universal Screening Tool Score at initial screening [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:df0b208d081a7cdeb91b5ef34e633e8b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0393e07c849ed56a58329126303652b3' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Response to the Appetite and Symptom Questionnaire at baseline [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:0393e07c849ed56a58329126303652b3' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1b679e273cb401f341b8330200b2ede0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Level of blood C-reactive protein at baseline [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:1b679e273cb401f341b8330200b2ede0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4d1ca3b8fe716e5671a5d7ec5b06b741' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Clinical condition, defined as diagnosis and stage of disease, treatment, and performance status at baseline [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:4d1ca3b8fe716e5671a5d7ec5b06b741' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:504a5645b7463d7db99c6db55152b3b5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to find out the effects (good and bad) Alpha-Lipoic Acid (ALA) has on preventing a side effect of platinum-containing chemotherapy called peripheral neuropathy. In this study, one group of subjects will receive Alpha-Lipoic Acid (ALA) and another group will receive a placebo control pill. A placebo control pill is a &quot;look-a-like&quot; pill but does not have any medication in it. Another name for placebo pill is &quot;sugar pill.&quot; Peripheral neuropathy is an abnormal, uncomfortable, often painful, sensations and feelings in hands or feet. The sensations and feelings in the hands and feet can effect the normal use of the hands and feet, such as in buttoning, writing, typing, sewing, picking up small objects, and walking. Currently there is no standard or reliable therapy to prevent this type of neuropathy. Alpha-Lipoic Acid (ALA) is a dietary supplement that is supposed to prevent or reduce the symptoms.</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:504a5645b7463d7db99c6db55152b3b5' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Prevention of Cisplatin- or Oxaliplatin-Induced Peripheral Neuropathy With Alpha-Lipoic Acid: A Placebo-Controlled Phase III Trial</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:70f1ec837eef02e5b447288647e7b6fd' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c558358185700b1174b6366c0ed65ec1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Scheduled to receive a cisplatin- or oxaliplatin-containing chemotherapy regimen for cancer</li>\n<li>No established clinical neuropathy</li>\n<li>No clinically evident CNS metastases, including leptomeningeal metastases</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS: AGE\n<ul>\n<li>Not specified PERFORMANCE STATUS</li>\n<li>Not specified LIFE EXPECTANCY</li>\n<li>Not specified HEMATOPOIETIC</li>\n<li>Not specified HEPATIC</li>\n<li>Bilirubin &lt; 2 mg/dL RENAL</li>\n<li>Creatinine &lt; 2 mg/dL OR</li>\n<li>Creatinine clearance &gt; 45 mL/min OTHER</li>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test</li>\n<li>Fertile patients must use effective contraception</li>\n<li>Must have a normal state of arousal</li>\n<li>No confusion or memory or concentration deficit</li>\n<li>No history of diabetes mellitus requiring oral medication or insulin treatment</li>\n<li>No chronic alcoholism</li>\n<li>No other active CNS disease (e.g., dementia or encephalopathy)</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY: BIOLOGIC THERAPY\n<ul>\n<li>Not specified CHEMOTHERAPY</li>\n<li>See Disease Characteristics</li>\n<li>No carboplatin, vincristine, vinblastine, paclitaxel, or docetaxel for 6 months prior, during, and 6 months after study treatment ENDOCRINE THERAPY</li>\n<li>Not specified RADIOTHERAPY</li>\n<li>Not specified SURGERY</li>\n<li>Not specified OTHER</li>\n<li>Concurrent medications that can modify peripheral neuropathy (e.g., gabapentin, lamotrigine, carbamazepine, phenytoin, or tricyclic antidepressants) are allowed provided there is no dose adjustment within 2 weeks before study entry and during study participation</li>\n<li>No concurrent vitamin E (including multivitamins that contain vitamin E) &#8805; 100 IU per day</li>\n<li>No concurrent physical modality (e.g., annodyne [monochromatic near-infrared photoenergy, 890 nm], microcurrent, or transcutaneous electrical neural stimulation) for peripheral neuropathy related symptoms unless physical or occupational therapy for functional training</li>\n</ul>\n</p>', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:c558358185700b1174b6366c0ed65ec1' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Group differences in change scores from baseline at 6-8, 12, 24, 36, and 48 weeks [&nbsp;Time&nbsp;Frame:&nbsp;2 years&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:b7017f2a141d6075d915f615de63060c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Number of courses received [&nbsp;Time&nbsp;Frame:&nbsp;2 years&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:62249da00011075adfe8607794114713' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7322b04da0615ce694db691b0a4081dc' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Optimal tumor response [&nbsp;Time&nbsp;Frame:&nbsp;2 years&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283570780, expire = 1283657180, headers = '', serialized = 0 WHERE cid = '1:7322b04da0615ce694db691b0a4081dc' in /persistent/html/includes/cache.inc on line 109.

Aerobic Exercise in Patients Receiving Chemotherapy for Cancer

Recruitment status: 
Completed

RATIONALE: Aerobic exercise may help prevent side effects caused by chemotherapy and help improve heart health. PURPOSE: This randomized clinical trial is studying the side effects of aerobic exercise and to see how well it works in patients receiving chemotherapy for cancer.

Background information
Trial ID: 
NCT00728429
Other unique IDs: 
CDR0000601334
CCCWFU-99108
CCCWFU-IRB-IRB00006209
Official title: 

CCCWFU 99108 - Effect of Exercise Training in Patients Receiving Anthracycline Drugs - A Pilot Study

Detailed description: 

OBJECTIVES:

  • To determine if patients with cancer can exercise safely and routinely, under supervision, while receiving anthracycline chemotherapy.
  • To determine the magnitude of the change in the peak ventilatory oxygen uptake (VO2) before and after completion of anthracycline chemotherapy with concurrent exercise versus without exercise in patients with cancer.

Number to be enrolled: 
28 patients

Radiation Therapy in Treating Patients With Metastatic Spinal Cord Compression

Recruitment status: 
Recruiting

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy regimen is more effective in treating metastatic spinal cord compression. PURPOSE: This randomized clinical trial is comparing two radiation therapy regimens to see how well they work in treating patients with metastatic spinal cord compression.

Background information
Trial ID: 
NCT00727584
Other unique IDs: 
CDR0000599886
CRUK-UCL-BRD/07/010
CRUK-SCORAD
ISRCTN97555949
EU-20863
Official title: 

SCORAD: A Randomised Feasibility Study of Single Fraction Radiotherapy Compared to Multi-Fraction Radiotherapy in Patients With Metastatic Spinal Cord Compression

Detailed description: 

OBJECTIVES:

  • To examine whether a phase III randomized study comparing a single-fraction of radiotherapy with multi-fraction radiotherapy is acceptable to clinicians and to patients with metastatic spinal cord compression.
  • To determine the feasibility of conducting this study in the United Kingdom.

Number to be enrolled: 
100 patients

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

Recruitment status: 
Recruiting

RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.

Background information
Trial ID: 
NCT00726830
Other unique IDs: 
CDR0000598283
MDA-2007-0791
Official title: 

A Randomized Comparison of Oral Methadone as a "First-Switch" Opioid Versus Opioid Switching Between Sustained-Release Morphine and Oxycodone for Oncology-Hematology Outpatients With Pain Management Problems: The "Simply Rotate" Study

Detailed description: 

OBJECTIVES: Primary

  • To compare the effectiveness of an opioid rotation to oral methadone versus an opioid rotation to another long-acting strong opioid (sustained-release morphine or oxycodone) in controlling pain (i.e., analgesia) in patients with cancer.

Number to be enrolled: 
300 patients

Sirolimus in Treating Patients With Cowden Syndrome or Another Germline Mutation Syndrome

RATIONALE: Sirolimus may stop the growth of abnormal cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well sirolimus works in treating patients with Cowden syndrome or another germline mutation syndrome.

Background information
Other unique IDs: 
CDR0000600867
NCI-08-C-0151
NCI-P07252

American Ginseng in Treating Patients With Fatigue Caused by Cancer

RATIONALE: American ginseng may reduce fatigue in patients with cancer. It is not yet known whether American ginseng is more effective than a placebo in treating cancer-related fatigue. PURPOSE: This randomized phase III trial is studying American ginseng to see how well it works in treating patients with fatigue caused by cancer.

Background information
Other unique IDs: 
CDR0000597665
NCCTG-N07C2

Hydroxychloroquine and Temozolomide in Treating Patients With Metastatic or Unresectable Solid Tumors

RATIONALE: Drugs used in chemotherapy, such as hydroxychloroquine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of hydroxychloroquine when given together with temozolomide in treating patients with metastatic or unresectable solid tumors.

Background information
Other unique IDs: 
CDR0000600329
UPCC-12907

Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer

Trial phase: 
Phase II
Recruitment status: 
Recruiting

RATIONALE: Morphine may reduce pain in patients who have undergone radiofrequency ablation to remove bone metastases. PURPOSE: This phase II trial is studying how well morphine works after radiofrequency ablation of painful bone metastases in patients with cancer.

Background information
Trial ID: 
NCT00712712
Other unique IDs: 
CDR0000589594
IB-MEDOR
IB-2007-16
INCA-RECF0498
EUDRACT-2007-002686-13
Official title: 

Evaluation of the Effectiveness of the Radiofrequency Ablation for Reducing Refractory Pain From Bone Metastases

Detailed description: 

OBJECTIVES: Primary

  • Measure the efficacy of morphine sulfate at 8 weeks after radiofrequency ablation (RFA) of bone metastases.

Number to be enrolled: 
63 patients

Docetaxel, Oxaliplatin, and Fluorouracil in Treating Patients With Metastatic or Unresectable Stomach Cancer, Gastroesophageal Junction Cancer, or Other Solid Tumor

Trial phase: 
Phase I
Recruitment status: 
Recruiting

RATIONALE: Drugs used in chemotherapy, such as docetaxel, oxaliplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of docetaxel when given with oxaliplatin and fluorouracil and to see how well they work in treating patients with metastatic or unresectable stomach cancer, gastroesophageal junction cancer, or other solid tumor.

Background information
Trial ID: 
NCT00711243
Other unique IDs: 
CDR0000599734
NU-0412
SANOFI - AVENTIS-NU0412
NU-948-006
Official title: 

A Phase I/II Study of Taxotere, Oxaliplatin, and 5- Fluorouracil

Detailed description: 

OBJECTIVES: Primary

  • To establish the maximum tolerated dose of docetaxel when administered with oxaliplatin and fluorouracil in patients with metastatic or unresectable solid tumors. (Phase I)
  • To determine the response rate in patients with metastatic or unresectable adenocarcinoma of the stomach or gastroesophageal junction treated with this regimen. (Phase II)

Number to be enrolled: 
73 patients

Screening to Predict Weight Loss in Patients With Cancer

Recruitment status: 
Recruiting

RATIONALE: Screening tests may identify people with cancer who are at high risk of losing weight and help doctors plan better treatment. PURPOSE: This clinical trial is studying how well a new screening tool works in predicting weight loss in patients with cancer.

Background information
Trial ID: 
NCT00710632
Other unique IDs: 
CDR0000590278
QMC-WEIGHT
EU-20831
Official title: 

Predicting Weight Loss in People With Cancer: Development of a Screening Tool

Detailed description: 

OBJECTIVES:

  • To identify people with cancer who are at greatest risk of future weight loss by the development of a simple and practical screening tool.
  • To estimate the reliability of the Appetite and Symptom Questionnaire (part 1).
  • To develop a screening tool based on the ability of the optimal combination of items from the three measures (ASQ, MUST, CRP) to predict clinically significant weight loss over three months (part 2).
  • To estimate the sensitivity and specificity at various cut-points of the developed screening tool in predicting clinically signifi
Number to be enrolled: 
220 patients

Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer

Trial phase: 
Phase III
Recruitment status: 
Recruiting

The purpose of this study is to find out the effects (good and bad) Alpha-Lipoic Acid (ALA) has on preventing a side effect of platinum-containing chemotherapy called peripheral neuropathy. In this study, one group of subjects will receive Alpha-Lipoic Acid (ALA) and another group will receive a placebo control pill. A placebo control pill is a "look-a-like" pill but does not have any medication in it. Another name for placebo pill is "sugar pill." Peripheral neuropathy is an abnormal, uncomfortable, often painful, sensations and feelings in hands or feet. The sensations and feelings in the hands and feet can effect the normal use of the hands and feet, such as in buttoning, writing, typing, sewing, picking up small objects, and walking. Currently there is no standard or reliable therapy to prevent this type of neuropathy. Alpha-Lipoic Acid (ALA) is a dietary supplement that is supposed to prevent or reduce the symptoms.

Background information
Trial ID: 
NCT00705029
Other unique IDs: 
0120070249
Official title: 

Prevention of Cisplatin- or Oxaliplatin-Induced Peripheral Neuropathy With Alpha-Lipoic Acid: A Placebo-Controlled Phase III Trial

Detailed description: 

 

Number to be enrolled: 
244 patients
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