Prostate Cancer

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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Gathering information about anxiety and depression in patients with localized prostate cancer who have selected watchful waiting may help doctors develop educational materials that help patients cope with cancer-related anxiety. PURPOSE: This study is looking at the educational needs of patients who are undergoing watchful waiting for localized prostate cancer.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:704eaa6c2f089793a5197ae75de47e9e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4d54e1f0f3c5bacddc3e6948d173bc6e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also stop the growth of prostate cancer by blocking blood flow to the tumor. Giving docetaxel together with cetuximab may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving docetaxel together with cetuximab and to see how well it works in treating patients with metastatic prostate cancer.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:4d54e1f0f3c5bacddc3e6948d173bc6e' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Overall survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Adverse events [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:38d8cff9a4f7007df4b9e9e667a2bb28' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>PFS at 24 weeks [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:0022ea2a06593c3486bb68775c4d141c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Prostate-specific antigen (PSA) response (30% and 50% PSA response) [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:e2a031529e04c93f96f2b097ea9968cb' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Tumor assessment of measurable disease according to RECIST criteria [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:aa4ec10f8fa9b1d957f05fa6f905e8b1' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Tumor assessment of bone lesions [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:e8591ba43b6f1c4e961bed6c3428e9ee' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>An Open-Label, Multi-Centre, Randomised Parallel-Group Study, Investigating Efficacy and Safety of Different Degarelix Three-Month Dosing Regimens in Patients with Prostate Cancer Requiring Androgen Ablation Therapy.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:8868bc80bc66083da4a354b0a3623159' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The Rationale of the Study is to Demonstrate That Degarelix Given at Three-Month Dosing Intervals Will Produce and Maintain Androgen Deprivation in Prostate Cancer Patients Through Immediate and Prolonged Testosterone Suppression, and to Provide Confirmat</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:48d4c8b5d90bd43e6fee8d5d46501145' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Patients, aged 18 years or older, with a histologically proven prostate cancer of all stages in whom endocrine treatment is indicated.</li>\n<li>Screening testosterone level above the lower limit of normal range, globally defined as &gt; 2.2 ng/mL.</li>\n<li>Screening PSA level of =2 ng/mL. ECOG score of =2.</li>\n<li>Life expectancy of at least one year.</li>\n</ul>\n</p><p> CRITERIA FOR EVALUATION: Primary endpoint:\n<ul>\n<li>Probability of testosterone at castrate level (=0.5 ng/mL) from Day 28 through Day 364.</li>\n</ul>\n</p><p> Secondary endpoints:\n<ul>\n<li>Probability of testosterone at castrate level (=0.5 ng/mL) from Day 56 through Day 364.</li>\n<li>Serum levels of testosterone, LH, FSH, and PSA over time.</li>\n<li>Time to PSA failure - defined as two consecutive increases of 50%, and at least 5 ng/mL, compared to nadir.</li>\n<li>Plasma levels of degarelix over time.</li>\n<li>Frequency and severity of adverse events.</li>\n<li>Clinically significant changes in laboratory safety parameters.</li>\n<li>Clinically significant changes in physical examinations, ECGs, vital signs, and body weight.</li>\n</ul>\n</p>', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:6c5c07dc37df7749fdfc07187dd0d28d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:17572074a0ed0e55c7d602236655d0a5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To evaluate testosterone, PSA, LH, and FSH responses during one year of treatment. [&nbsp;Time&nbsp;Frame:&nbsp;3-month&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:17572074a0ed0e55c7d602236655d0a5' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To evaluate pharmacokinetic response. [&nbsp;Time&nbsp;Frame:&nbsp;3-month&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:a319dfe5516ac5cf01d613aaa42c4f6b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8f041415dbc16218a2c5338d1abdd7a7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To compare safety and tolerability profiles of different degarelix three-month dosing regimens. [&nbsp;Time&nbsp;Frame:&nbsp;3-month&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:8f041415dbc16218a2c5338d1abdd7a7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a5118750d1cd9b2430a828061749b870' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Hydroxychloroquine may stop the growth of tumor cells by blocking some of the cellular functions needed for cells to survive. PURPOSE: This phase II trial is studying how well hydroxychloroquine works in treating patients with rising prostate-specific antigen (PSA) levels after local therapy for prostate cancer.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:a5118750d1cd9b2430a828061749b870' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to compare the effects of pomegranate polyphenol pills (POM-X) and a placebo (sugar pill) on prostatic oxidative stress. The placebo is a pill that looks like the POM-X pill but does not have an active ingredient.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:c6ebd0cdc04789ce7799192bb6bcd34a' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Randomized, Placebo-Controlled, Pre-Surgical Study of the Effects of Pomegranate Pills in Men With Prostate Cancer Prior to Radical Prostatectomy</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:3ed976a5184027be3186af91ed13dc63' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a221ab287ef328e599603b63a60ec728' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Subjects will receive POM-X or placebo pills daily for up to 4 weeks prior to undergoing radical prostatectomy for prostate cancer. Biomarkers in the blood, urine, and prostate tissue will be assessed.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:a221ab287ef328e599603b63a60ec728' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ef3a2ab588ba6218ac9aabd25648064b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ol>\n<li>Histologically confirmed adenocarcinoma of the prostate, without evidence of spread beyond to lymph nodes, bone, or visceral organs.</li>\n<li>Radical prostatectomy scheduled at UCLA or Johns Hopkins.</li>\n<li>Initial prostate biopsy available for review with tumor involving 2 or more core biopsies based on pathologic review.</li>\n<li>Age &#8805; 18 years of age.</li>\n<li>Willingness and ability to sign an informed consent document.</li>\n<li>Agreement with complete abstinence from other commercially available pomegranate products during the course of the study.</li>\n<li>No prior allergy to pomegranate dietary agents.</li>\n<li>No significant medical or psychiatric condition that would make the patient a poor protocol candidate.</li>\n<li>The patient agrees to stop taking dietary or vitamin supplements (lycopene, vitamin E, selenium, genistein) or herbal supplements (eg. saw palmetto) for 2-weeks prior to staring the study.</li>\n<li>The patient is not taking LHRH agonists, androgen receptor blocking agents or finasteride, and has not undergone bilateral orchiectomy.</li>\n<li>Patient has not received experimental medications within the past six months.</li>\n</ol>\n</p><p> Exclusion Criteria:\n<ol>\n<li>Significant concomitant medical or psychiatric condition that, in the opinion of the investigator, would make the participant a poor protocol candidate.</li>\n<li>Concomitant or antecedent hormonal therapy.</li>\n<li>Known allergy to pomegranate juice.</li>\n<li>Subjects unable or unwilling to comply with protocol requirements.</li>\n<li>Evidence of metastatic disease on physical examination or on CT or bone scan.</li>\n<li>Use of finasteride, dutasteride at any point during the study.</li>\n<li>Clinically significant abnormal laboratory value &gt;2X the upper limit of normal (2XULN).</li>\n</ol>\n</p>', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:ef3a2ab588ba6218ac9aabd25648064b' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This is a phase I/II, open-label, dose escalation study of HE3235 administered orally to patients with advanced prostate cancer who have failed hormone therapy and at least one taxane based chemotherapy regimen.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:a800e182e5abd34179f4135597c41e76' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6685bc865bcb9410ccb3b23707ebda9b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase I/II, Open-Label, Dose Ranging Study of the Safety, Tolerance, Pharmacokinetics and Potential Activity of HE3235 When Administered Orally to Patients With Prostate Cancer</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:6685bc865bcb9410ccb3b23707ebda9b' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Main Inclusion Criteria:\n<ul>\n<li>Patient is male and at least 18 years of age, at the time of screening;</li>\n<li>Patient has metastatic disease (any T, any N, M1);</li>\n<li>Patient has failed at least 1 taxane regimen;</li>\n<li>Patient has histologically or cytologically confirmed adenocarcinoma of the prostate;</li>\n<li>Patient has progression of disease despite adequate hormone therapy, demonstrated by one of the following:\n<ul>\n<li>PSA level of at least 2 ng/ml that has risen on at least 2 successive occasions, at least 1 week apart.</li>\n<li>Evaluable disease progression by modified RECIST (Response Evaluation Criteria in Solid Tumors) criteria;</li>\n<li>Progression of metastatic bone disease on bone scan with &gt; 2 new lesions</li>\n</ul>\n</li>\n<li>Patient has ECOG (Eastern Cooperative Oncology Group) performance status of 0-2;</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Patient has symptomatic parenchymal brain metastases or active epidural disease requiring whole-brain irradiation Treated epidural disease is allowed</li>\n<li>Patient has active infection;</li>\n<li>Patient having a history of clinically significant cardiovascular disease (such as CHF), clinically significant hepatic, respiratory or renal abnormalities;</li>\n<li>Patient who has any clinically significant abnormalities in laboratory results at screening</li>\n<li>Patient who has a history of clinically significant neurological or psychiatric condition;</li>\n</ul>\n</p>', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:50cef5d0079c2325a707a083b5bbd8d3' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To evaluate the safety and tolerance of HE3235 when administered orally to prostate cancer patients in 28 day cycles. [&nbsp;Time&nbsp;Frame:&nbsp;Treatment period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:7e40d909d82e689e778fc827be9ab23c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To evaluate the pharmacokinetic profiles of HE3235 and major metabolites at different dose levels after 28 days of dosing. [&nbsp;Time&nbsp;Frame:&nbsp;Treatment period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:f01158ffeb67b029ca226a37106109f3' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b91af8811f368196bc7a2e02422c14cc' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>To assess potential activity of HE3235 in prostate cancer patients. [&nbsp;Time&nbsp;Frame:&nbsp;Treatment period and post-study follow-up period&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:b91af8811f368196bc7a2e02422c14cc' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Evaluate the role of molecular profiling of CTC in predicting sensitivity to treatment and treatment response. [&nbsp;Time&nbsp;Frame:&nbsp;Treament period and post-study follow-up&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:71b0a73e5ac6adb2095d682124ce5804' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This is an open label, Phase 2 trial of immunotherapy with sipuleucel-T as neoadjuvant treatment in men with localized prostate cancer.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:a9ed1060a6b01c08259e341850229f7c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Single Center, Open Label, Phase 2 Trial of Immunotherapy With Sipuleucel-T as Neoadjuvant Treatment in Men With Localized Prostate Cancer</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:382bc8d40249e85823489b842990c2cb' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:208ff6da6a8b84b5b4215b6750bde370' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This is a single center, open label, Phase 2 study. Subjects will be treated with 3 infusions of sipuleucel-T prior to a scheduled radical prostatectomy (RP) surgery. To assess the immune response following treatment with sipuleucel-T, tissue from the prostatectomy specimen will be compared with tissue from the core biopsy specimen obtained prior to treatment with sipuleucel T. Following RP, subjects will be randomized to receive either a booster infusion of sipuleucel T or no further treatment with sipuleucel-T (i.e., booster: no booster).</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:208ff6da6a8b84b5b4215b6750bde370' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:20081920b649bd45e894f8c3003af1e5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria Eligible subjects must meet all of the following criteria.\n<ul>\n<li>Adenocarcinoma of the prostate.</li>\n<li>Subject is scheduled for RP as the initial therapy for localized prostate cancer.</li>\n<li>Subject is &#8805; 18 years of age.</li>\n<li>Subject has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.</li>\n<li>Subject has adequate hematologic, renal, and liver function.</li>\n</ul>\n</p><p> Exclusion Criteria A subject is not eligible for study participation if any of the following criteria apply.\n<ul>\n<li>Subject has any evidence of metastasis.</li>\n<li>Subject received hormones, including luteinizing hormone-releasing hormone agonists, antiandrogens, or 5 &#945;-reductase inhibitors at any time prior to study screening.</li>\n<li>Subject has received prior radiation therapy or chemotherapy for prostate cancer.</li>\n<li>Subject has received systemic steroid therapy within 14 days.</li>\n<li>Subject has a history of stage III or greater cancer, excluding prostate cancer. Subjects with a history of basal or squamous cell skin cancers are allowed, provided that the subject was adequately treated and is disease-free at the time of study screening. Subjects with a history of stage I or II cancer must have been adequately treated and been disease-free for &#8805; 3 years prior to study screening.</li>\n</ul>\n</p>', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:20081920b649bd45e894f8c3003af1e5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fc238f4a2e6f12e6206e4ef8bb2edd22' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This is a randomized, multicenter, single blind, Phase 2 trial of immunotherapy in men with metastatic androgen independent prostate cancer to evaluate sipuleucel-T manufactured with different concentrations of PA2024 antigen</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:fc238f4a2e6f12e6206e4ef8bb2edd22' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Evaluate the overall survival in each of the cohorts. [&nbsp;Time&nbsp;Frame:&nbsp;Overall survival will be evaluated after the last living subject has completed the Month 36 visit.&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:564a13c91b7fa5f83fbb5f45d6ea4e8a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:130b14362cee3c5edcca679b82b359c1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase II trial is studying the side effects of internal radiation therapy when given with or without external-beam radiation therapy and to see how well it works in treating patients with localized prostate cancer.</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:130b14362cee3c5edcca679b82b359c1' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Overall survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Disease-free survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:955254cde948984eb9e60ebac1471e8a' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Disease-specific survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:3a471e31c67439bb594bd79567eda6ca' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Association between dose-volume limitations for organs at risk and rate and severity of GU or GI adverse events [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:68acdb8bb12aafe48a788a8d38d19400' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Patient preference for a second treatment (a second high dose-rate brachytherapy session or an external beam radiotherapy session) [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283572328, expire = 1283658728, headers = '', serialized = 0 WHERE cid = '1:f3090ec6d03057e6f1c85198c119f27e' in /persistent/html/includes/cache.inc on line 109.
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Educational Needs of Patients Undergoing Watchful Waiting for Localized Prostate Cancer

RATIONALE: Gathering information about anxiety and depression in patients with localized prostate cancer who have selected watchful waiting may help doctors develop educational materials that help patients cope with cancer-related anxiety. PURPOSE: This study is looking at the educational needs of patients who are undergoing watchful waiting for localized prostate cancer.

Background information
Other unique IDs: 
CDR0000600452
BCM-H-19995

Docetaxel and Cetuximab in Treating Patients With Metastatic Prostate Cancer

RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also stop the growth of prostate cancer by blocking blood flow to the tumor. Giving docetaxel together with cetuximab may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving docetaxel together with cetuximab and to see how well it works in treating patients with metastatic prostate cancer.

Background information
Other unique IDs: 
CDR0000599858
SWS-SAKK-08/07
MERCK-SAKK-0807
SANOFI-AVENTIS-SWS-SAKK-0807

Open-Label, Randomised Parallel-Group Study

Trial phase: 
Phase III
Recruitment status: 
Terminated

An Open-Label, Multi-Centre, Randomised Parallel-Group Study, Investigating Efficacy and Safety of Different Degarelix Three-Month Dosing Regimens in Patients with Prostate Cancer Requiring Androgen Ablation Therapy.

Background information
Trial ID: 
NCT00728533
Other unique IDs: 
FE 200486 CS26
2007-006055-39
Official title: 

The Rationale of the Study is to Demonstrate That Degarelix Given at Three-Month Dosing Intervals Will Produce and Maintain Androgen Deprivation in Prostate Cancer Patients Through Immediate and Prolonged Testosterone Suppression, and to Provide Confirmat

Detailed description: 

 

Number to be enrolled: 
0 patients

Hydroxychloroquine in Treating Patients With Rising PSA Levels After Local Therapy for Prostate Cancer

RATIONALE: Hydroxychloroquine may stop the growth of tumor cells by blocking some of the cellular functions needed for cells to survive. PURPOSE: This phase II trial is studying how well hydroxychloroquine works in treating patients with rising prostate-specific antigen (PSA) levels after local therapy for prostate cancer.

Background information
Other unique IDs: 
CDR0000600326
CINJ-080803

A Study Of the Effectiveness Of Pomegranate Pills in Men With Prostate Cancer Before Prostatectomy

Recruitment status: 
Recruiting

The purpose of this study is to compare the effects of pomegranate polyphenol pills (POM-X) and a placebo (sugar pill) on prostatic oxidative stress. The placebo is a pill that looks like the POM-X pill but does not have an active ingredient.

Background information
Trial ID: 
NCT00719030
Other unique IDs: 
GUP-0515-02
Official title: 

A Randomized, Placebo-Controlled, Pre-Surgical Study of the Effects of Pomegranate Pills in Men With Prostate Cancer Prior to Radical Prostatectomy

Detailed description: 

Subjects will receive POM-X or placebo pills daily for up to 4 weeks prior to undergoing radical prostatectomy for prostate cancer. Biomarkers in the blood, urine, and prostate tissue will be assessed.

Number to be enrolled: 
35 patients

A Phase I/II Study of HE3235 in Patients With Prostate Cancer

Trial phase: 
Phase II
Recruitment status: 
Recruiting

This is a phase I/II, open-label, dose escalation study of HE3235 administered orally to patients with advanced prostate cancer who have failed hormone therapy and at least one taxane based chemotherapy regimen.

Background information
Trial ID: 
NCT00716794
Other unique IDs: 
HE3235-0201
Official title: 

A Phase I/II, Open-Label, Dose Ranging Study of the Safety, Tolerance, Pharmacokinetics and Potential Activity of HE3235 When Administered Orally to Patients With Prostate Cancer

Detailed description: 

 

Number to be enrolled: 
44 patients

Sipuleucel-T as Neoadjuvant Treatment in Prostate Cancer

Trial phase: 
Phase II
Recruitment status: 
Recruiting

This is an open label, Phase 2 trial of immunotherapy with sipuleucel-T as neoadjuvant treatment in men with localized prostate cancer.

Background information
Trial ID: 
NCT00715104
Other unique IDs: 
P07-1
Official title: 

A Single Center, Open Label, Phase 2 Trial of Immunotherapy With Sipuleucel-T as Neoadjuvant Treatment in Men With Localized Prostate Cancer

Detailed description: 

This is a single center, open label, Phase 2 study. Subjects will be treated with 3 infusions of sipuleucel-T prior to a scheduled radical prostatectomy (RP) surgery. To assess the immune response following treatment with sipuleucel-T, tissue from the prostatectomy specimen will be compared with tissue from the core biopsy specimen obtained prior to treatment with sipuleucel T. Following RP, subjects will be randomized to receive either a booster infusion of sipuleucel T or no further treatment with sipuleucel-T (i.e., booster: no booster).

Number to be enrolled: 
40 patients
Acronym: 
NeoACT

To Evaluate Sipuleucel-T Manufactured With Different Concentrations of PA2024 Antigen

This is a randomized, multicenter, single blind, Phase 2 trial of immunotherapy in men with metastatic androgen independent prostate cancer to evaluate sipuleucel-T manufactured with different concentrations of PA2024 antigen

Background information
Other unique IDs: 
P07-2

Internal Radiation Therapy With or Without External-Beam Radiation Therapy in Treating Patients With Localized Prostate Cancer

RATIONALE: Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase II trial is studying the side effects of internal radiation therapy when given with or without external-beam radiation therapy and to see how well it works in treating patients with localized prostate cancer.

Background information
Other unique IDs: 
CDR0000600446
MAYO-MC0652

Phase II Study of Docetaxel for Clinically Asymptomatic High Risk Prostate Cancer Patients

The purpose of this study is to assess the response to Taxotere (docetaxel) chemotherapy given as a primary treatment to patients with early and rapid PSA rising after prostatectomy for high risk disease.

Background information
Other unique IDs: 
Project 5.2.08.02
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