Lymphoma

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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Palifermin may help relieve or prevent oral mucositis caused by chemotherapy and radiation therapy in young patients undergoing stem cell transplant. PURPOSE: This randomized phase II trial is studying palifermin to see how well it works compared with a placebo in preventing oral mucositis caused by chemotherapy and/or radiation therapy in young patients undergoing stem cell transplant.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:73e17bcc1a94ebd672b913e6684b1727' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'A Group-Wide Double-Blind Randomized Placebo-Controlled Trial of Palifermin to Prevent Chemotherapy and/or Radiotherapy Induced Oral Mucositis in Children Undergoing Autologous or Allogeneic Hematopoietic Stem Cell Transplantation\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:df5f8ae469adb8470aa30e5df7c98a46' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES: Primary\n<ul>\n<li>To compare whether palifermin versus placebo administered to pediatric patients three days prior to conditioning and three days after autologous or allogeneic hematopoietic stem cell transplantation (HSCT) is associated with a reduction in the incidence of WHO grade 3 or 4 oral mucositis.</li>\n</ul>\n Secondary\n<ul>\n<li>To evaluate the safety and tolerability of palifermin.</li>\n<li>To evaluate the long-term effects of palifermin on disease outcome and survival.</li>\n<li>To compare the incidence, total dose, and duration of parenteral opioid analgesic use (morphine equivalents), and incidence and duration of total parenteral nutrition (TPN) administration in patients treated with these regimens.</li>\n<li>To compare the incidence of febrile neutropenia and invasive bacterial infections in patients treated with these regimens.</li>\n<li>To determine whether palifermin versus placebo reduces the incidence of WHO grade 3 or 4 oral mucositis among allogeneic HSCT pediatric patients receiving methotrexate as graft-versus-host disease (GVHD) prophylaxis.</li>\n<li>To determine whether palifermin versus placebo reduces acute and chronic GVHD after allogeneic HSCT.</li>\n<li>To describe health care utilization (hospitalization duration, and administration of antibiotics, TPN, nasogastric-, nasojejunal- or gastrostomy-administered enteral nutrition, and blood products) in pediatric patients treated with these regimens.</li>\n</ul>\n OUTLINE: This is a multicenter study. Patients are stratified according to age in years (1 to 2 vs 3 to 11 vs 12 to 16), type of hematopoietic stem cell transplantation (HSCT) (autologous vs allogeneic), conditioning regimen (either total-body irradiation [TBI] or melphalan vs neither TBI nor melphalan). Patients are randomized to 1 of 2 treatment arms.\n<ul>\n<li>Arm I: Patients receive palifermin IV once daily for 3 days prior to chemotherapy and/or radiotherapy in the absence of unacceptable toxicity.</li>\n</ul>\n Patients then receive palifermin IV on days 0, 1, and 2 after autologous or allogeneic HSCT.\n<ul>\n<li>Arm II: Patients receive placebo IV once daily for 3 days prior to chemotherapy and/or radiotherapy in the absence of unacceptable toxicity. Patients then receive placebo IV on days 0, 1, and 2 after autologous or allogeneic HSCT.</li>\n</ul>\n Blood samples are collected at baseline, 32 days, and 100 days after HSCT to evaluate the immunogenicity of palifermin. Oral mucositis is assessed at baseline, daily for 8 days prior to and 32 days after HSCT, or until oral mucositis has resolved by the WHO Mucositis Scale, Oral Mucositis Assessment Scale (OMAS), modified Walsh mucositis scale, Oral Mucositis Daily Questionnaire (OMDQ), and the pain categorical rating scale. After completion of HSCT, patients are followed periodically for up to 10 years.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:a35da0cfa0a7a86f6409af67c4b7bd98' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Patients undergoing myeloablative autologous or allogeneic hematopoietic stem cell transplantation (HSCT) for any indication</li>\n<li>Any type of myeloablative HSCT conditioning regimen allowed</li>\n<li>Patients undergoing allogeneic HSCT may undergo 1 of the following types of donor stem cells:\n<ul>\n<li>HLA-matched sibling or parent</li>\n<li>Partially matched family donor (mismatched for a single HLA locus [class I])</li>\n<li>Fully matched unrelated marrow or peripheral blood stem cell donor</li>\n<li>HLA-matched or partially mismatched (at least 4 of 6 match) cord blood (class I or II)</li>\n</ul>\n</li>\n</ul>\n PATIENT CHARACTERISTICS:\n<ul>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test</li>\n<li>Fertile patients must use effective contraception</li>\n<li>No HIV positivity</li>\n<li>No known sensitivity to any E. coli-derived products\n<ul>\n<li>Known grade 1 to 2 allergic reactions to asparaginase allowed</li>\n<li>No prior grade 3-4 allergies to asparaginase or pegaspargase</li>\n</ul>\n</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>More than 30 days since prior and no concurrent treatment with any of the following therapies:\n<ul>\n<li>Oral cryotherapy</li>\n<li>Glutamine as an oral supplement</li>\n<li>Traumeel®</li>\n<li>Gelclair®</li>\n<li>Oral vancomycin paste</li>\n<li>Low-level laser therapy</li>\n<li>An investigational product or device in another clinical trial</li>\n</ul>\n</li>\n<li>No prior palifermin or other keratinocyte growth factors</li>\n<li>No other concurrent cytotoxic drugs for conditioning or graft-vs-host disease prophylaxis\n<ul>\n<li>Intrathecal methotrexate or cytarabine for CNS involvement allowed</li>\n</ul>\n</li>\n</ul>\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:bb95235845e20e6a675762a6d3f40d7e' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Safety and tolerability of palifermin [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:ec6dbdc887d16cd51563c4748d35fa7e' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Long-term disease outcome and survival [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:8eebff6f10ca6c1fd499b9e8948d715b' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Duration of WHO grade 3 or 4 oral mucositis [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:0ba2af343f300b31fc7e925de958cb39' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence, total dose, and duration of parenteral opioid analgesic use (morphine equivalents) [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:efda079bce71216266982e184ec19e9c' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence and duration of total parenteral nutrition administration [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:02fac6ce9cae062f7b8ef9c212258471' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence of febrile neutropenia and invasive bacterial infections [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:9e8fe591e820bb46408a222bc02fcaff' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence of WHO grade 3 or 4 oral mucositis among allogeneic HSCT patients receiving methotrexate as GVHD prophylaxis [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:a24c53e1e9c2beb430185cc3a2a2a849' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence of acute and chronic GVHD after allogeneic HSCT [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:4d84bcb8e25523003f9e0c8a53ba6cfa' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Health care utilization [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:691942a1d6e9235aa1fe7f2d68315455' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Drugs used in chemotherapy, such as methotrexate and leucovorin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Glucarpidase may help return the level of methotrexate in the blood to a safe range. Giving high-dose methotrexate together with glucarpidase and leucovorin may kill more cancer cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of methotrexate when given together with glucarpidase and leucovorin in treating patients with newly diagnosed primary central nervous system lymphoma.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:ceae24433c4695b8093b6d98d435da08' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Immediate toxicity (incidence of reactions to glucarpidase) as determined by the NCI CTC [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:b3f705125988a6807999ecf2d5cc96d2' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence and severity of renal dysfunction as determined by the NCI CTC [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:eb9f2bdb5becc48fcf49d54e9b55b99c' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence and severity of mucositis as determined by the NCI CTC and WHO mucositis grading scale [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:e24e618ed8e6d0e66aa2eb3c976ca105' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence and severity of CNS toxicity and neurocognitive changes taken from patients\' medical records and measured using the Mini-Mental State questionnaire and MRI data [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:d893c90176ce92a8dbb00289b9a144fb' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Hematological toxicity (i.e., number of courses of therapy associated with neutrophils < 0.5 x 10e9/L or platelets < 50 x 10e9/L as measured by routine blood counts) [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:ea7a53931b27b1baecd66f76b0331fd7' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence of infection (i.e., number of days with fever ≥ 38 C° measured by clinical examination and days of intravenous antibiotics taken from patients\' medical records) [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:714f14b6297a11d98866632d6cde7103' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Number of inpatient days taken from patients\' medical records [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:bf895e33b9e57c04b91817bfa41a6061' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Disease response and remission rates measured by serial MRI scanning (and eye examination and lumbar puncture if necessary) [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:d54696598c7a251ca9f16baf305a3352' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Disease outcome, time to progression, and overall survival at 2 years from start of therapy measured by clinical examination and serial MRI scanning [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:2a1e60c5e06c2ab35bc63d945b69342b' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Methotrexate levels post-glucarpidase (expressed as a clinically important reduction, which is defined as a methotrexate level of < 1 μmol/L in all post-glucarpidase samples) [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:34f3c0c0a16caddcbc3fde5dc40482ba' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence of antibodies to glucarpidase measured serologically at the start of each methotrexate course and at follow-up visits if present during therapy [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:f68c6b75c743aa2df14c89e7b5285a9f' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well everolimus works in treating older patients with mantle cell lymphoma who received previous first-line or second-line chemotherapy.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:545ab9df754a1d19b02bcbd7fa1a1a57' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Phase II Trial on Efficacy of mTOR Inhibitor RAD001 as Maintenance Therapy for Patients Above 60 Years in Mantle Cell Lymphoma After First and Second Line Chemotherapy\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:b03897aa78dde42cec59628c20b7384f' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES: Primary\n<ul>\n<li>Determine the progression-free survival of older patients with mantle cell lymphoma receiving everolimus and who were previously treated with first- or second-line chemotherapy.</li>\n</ul>\n Secondary\n<ul>\n<li>Determine the toxicity and feasibility of treatment with this drug.</li>\n<li>Determine the efficacy of this drug in these patients.</li>\n<li>Compare the duration of remission after first- vs second-line chemotherapy.</li>\n<li>Determine the rate of objective remission.</li>\n</ul>\n OUTLINE: This is a multicenter study. Patients receive oral everolimus once daily in the absence of disease progression or unacceptable toxicity. After completion of study therapy, patients are followed periodically for 3 years.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:eaef3f183e579a5aa0b052e5c0540ba4' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7f121ab4981140f54a03560e17bb89ce' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Diagnosis of mantle cell lymphoma</li>\n<li>Stable disease after first- or second-line chemotherapy</li>\n<li>No uncontrolled cerebral or leptomeningeal disease</li>\n</ul>\n PATIENT CHARACTERISTICS:\n<ul>\n<li>WHO performance status 0-2</li>\n<li>Life expectancy ≥ 3 months</li>\n<li>Age ≥ 60 years or patients ≥ 40 and < 60 years who are not suitable for high-dose chemotherapy followed by autologous stem cell transplantation or allogeneic stem cell transplantation</li>\n<li>ANC ≥ 1,500/mm^3</li>\n<li>Platelet count ≥ 100,000/mm^3</li>\n<li>Hemoglobin > 9 g/dL</li>\n<li>Serum creatinine ≤ 1.5 times upper limit of normal (ULN)</li>\n<li>SGPT and SGOT ≤ 3 times ULN</li>\n<li>Bilirubin ≤ 1.5 times ULN</li>\n<li>No other malignancies within the past 3 years except treated cervical carcinoma or basal cell cancer</li>\n<li>No other serious or non-controlled illnesses (e.g., diabetes mellitus, uncontrolled hypertension, serious infections, serious malnutrition, unstable angina pectoris, weak heart, myocardial infarction within the past 6 months, chronic liver illness, active ulceration in the gastrointestinal tract, psychiatric illness)</li>\n<li>No known HIV infection</li>\n<li>No gastrointestinal disturbances that could influence the absorption of everolimus and cause short-intestine syndrome (e.g., atrophic gastritis)</li>\n<li>No coagulation or bleeding diatheses</li>\n<li>Not pregnant or nursing</li>\n<li>Fertile patients must use effective contraception</li>\n<li>Patients must have complied with their previous drug prescription</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>See Patient Characteristics</li>\n<li>Recovered from all prior therapy</li>\n<li>At least 2 weeks since prior surgery, radiotherapy, or systemic antitumor therapy</li>\n<li>More than 4 weeks since prior experimental medication</li>\n<li>No chronic therapy with systemic steroids or other immunosuppressants except rituximab</li>\n<li>No prior organ transplantation</li>\n<li>No therapy with vitamin K antagonist, except low-dose coumarin</li>\n<li>No prior mTOR inhibitors</li>\n</ul>\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:7f121ab4981140f54a03560e17bb89ce' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f2bf6dd49311399fa3e6884fca9fbb40' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Efficacy [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:f2bf6dd49311399fa3e6884fca9fbb40' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b1053376ace114d693d2a3a0bf5ef42f' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Toxicity and feasibility [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:b1053376ace114d693d2a3a0bf5ef42f' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b69eabc8e01a59ed4a24eec2467f8852' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Comparison of duration of remission after first- vs second-line chemotherapy [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:b69eabc8e01a59ed4a24eec2467f8852' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cbaf7ea2ff28a95ecd23511e5feec288' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Rate of objective remission [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:cbaf7ea2ff28a95ecd23511e5feec288' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:83093853389028cd1080b0720e1d5b9d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:83093853389028cd1080b0720e1d5b9d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e682a05167afedd5b7847872f75934f5' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'A Randomized Comparison of Oral Methadone as a "First-Switch" Opioid Versus Opioid Switching Between Sustained-Release Morphine and Oxycodone for Oncology-Hematology Outpatients With Pain Management Problems: The "Simply Rotate" Study\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:e682a05167afedd5b7847872f75934f5' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:76802cc08dc38182f705aec18b74013c' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES: Primary\n<ul>\n<li>To compare the effectiveness of an opioid rotation to oral methadone versus an opioid rotation to another long-acting strong opioid (sustained-release morphine or oxycodone) in controlling pain (i.e., analgesia) in patients with cancer.</li>\n</ul>\n Secondary\n<ul>\n<li>To compare the tolerability of an opioid rotation to oral methadone versus an opioid rotation to another long-acting strong opioid (sustained-release morphine or oxycodone).</li>\n<li>To identify a subset of patients most likely to benefit from an opioid rotation to oral methadone, in terms of significant improvement in pain control or opioid tolerability.</li>\n</ul>\n OUTLINE: This is a multicenter study. Patients are stratified according to their baseline opioid (morphine vs oxycodone). Patients are randomized to 1 of 2 treatment arms.\n<ul>\n<li>Arm I: Patients are switched from their current opioid medication (oxycodone or morphine) to methadone. Patients receive oral methadone 2-3 times daily for 4 weeks.</li>\n<li>Arm II: Patients currently receiving oxycodone are switched to sustained-release (SR) morphine. Patients currently receiving morphine are switched to SR oxycodone. Patients receive either oral SR morphine or oxycodone 2-3 times daily for 4 weeks.</li>\n</ul>\n Patients are assessed for pain control and complete a symptom questionnaire on days 1, 8, 15, 22, and 28.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:76802cc08dc38182f705aec18b74013c' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b46412cca3c03de4baffb656fd8990bb' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Receiving ongoing care in the outpatient medical oncology setting</li>\n<li>Self-reported pain (of any cause) for which long-acting strong opioids (morphine or oxycodone) have been prescribed or administered\n<ul>\n<li>Oral morphine-equivalent daily dose (MEDD) of existing opioid regimen (long-acting or immediate-release) 40-300 mg/day</li>\n</ul>\n</li>\n<li>Worst pain score on a scale of 0 (no pain) to 10 (worst pain) of ≥ 5 for ≥ 1 week duration based on verbal self-report AND/OR ≥ 1 persistently bothersome symptom attributed to an opioid side effect (e.g., fatigue, confusion, depressed level of consciousness, memory loss, personality change, anorexia, constipation, dehydration, nausea, vomiting, weight loss, pruritus, urticaria, impotence, reduced libido, and urinary retention or hesitancy)</li>\n</ul>\n PATIENT CHARACTERISTICS:\n<ul>\n<li>None of the following conditions that could predispose the patient to prolonged QT interval-associated tachycardia:\n<ul>\n<li>Serum potassium < 3.0 mg/dL</li>\n<li>Cocaine abuse within the past 3 months</li>\n<li>Family history of sudden death</li>\n<li>Advanced heart failure (ejection fraction < 40% and/or NYHA class III or IV heart disease)</li>\n</ul>\n</li>\n<li>No known or suspected cognitive impairment that could interfere with adherence to the medication plan or self-report of symptoms and side effects</li>\n<li>Not pregnant or nursing</li>\n<li>Fertile patients must use effective contraception</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>More than 4 weeks since prior radiotherapy or surgery for local control of cancer or pain palliation</li>\n<li>More than 60 days since prior use of the same long-acting opioid (i.e., the new long-acting opioid) that patient is switching to on the study</li>\n<li>More than 12 weeks since prior methadone therapy</li>\n<li>More than 3 days since prior and no concurrent transdermal fentanyl, oxymorphone, or buprenorphine</li>\n<li>Concurrent systemic anticancer therapy or bisphosphonates allowed provided therapy was initiated ≥ 4 weeks ago</li>\n<li>Concurrent tricyclic antidepressants, NSAIDs, anticonvulsants, or other adjuvant analgesics or psychostimulants allowed provided therapy was initiated ≥ 2 weeks ago\n<ul>\n<li>Dose expected to remain stable until after the first week of opioid rotation on study</li>\n</ul>\n</li>\n<li>No concurrent methadone maintenance therapy for opioid addiction</li>\n<li>No concurrent intrathecal infusion of analgesics</li>\n<li>No concurrent antiarrhythmic medications (e.g., amiodarone or quinidine)</li>\n</ul>\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:b46412cca3c03de4baffb656fd8990bb' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:16e9ff6530662c4e767ab2cbf540d2e9' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '30% reduction in patients\' total summary score for the individual composite drug toxicity score (CDTS) items [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:16e9ff6530662c4e767ab2cbf540d2e9' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a745fbf8b3911431b7c93870d4965fdf' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Identification of a subset of patients most likely to benefit from an opioid rotation to oral methadone, in terms of significant improvement in pain control or opioid tolerability [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:a745fbf8b3911431b7c93870d4965fdf' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:40e4d5e43ddb457ea11da9120b1a10d1' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, and vincristine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Colony-stimulating factors, such as pegfilgrastim, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of chemotherapy. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. It is not yet known whether combination chemotherapy and pegfilgrastim is more effective when given with or without rituximab in treating non-Hodgkin lymphoma. PURPOSE: This phase II trial is studying the side effects of giving pegfilgrastim and combination chemotherapy together with or without rituximab and to see how well it works in treating older patients with aggressive B-cell non-Hodgkin lymphoma.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:40e4d5e43ddb457ea11da9120b1a10d1' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7b6565712fa18275e790703b2fb743d8' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Side effects [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:7b6565712fa18275e790703b2fb743d8' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:221fb71092d60fb985f79a06ea0b44f0' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Adherence to therapy regimens [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:221fb71092d60fb985f79a06ea0b44f0' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:99e245b284fc5df0615501bc931d2ebb' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Antitumor effectivity [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:99e245b284fc5df0615501bc931d2ebb' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3f8cee2eaded01b7adb48dd97b8bbd33' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'The primary objective of this study is to determine safety, tolerability, dose-limiting toxicities and recommended dose of SCH 900105 administered intravenously (IV) to subjects with relapsed or refractory solid tumors or lymphoma.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:3f8cee2eaded01b7adb48dd97b8bbd33' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f0e311aae5e23ecbaf91f41d946857bb' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Pharmacokinetics of SCH 900105 [ Time Frame: Throughout treatment and then during follow-up, 30 days and 60 days (if feasible) after the last dose of study medication. ] [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:f0e311aae5e23ecbaf91f41d946857bb' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:89d4d4629a78965daf5ceb3cb7fd6152' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Preliminary evaluation of tumor responses [ Time Frame: Throughout treatment ] [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:89d4d4629a78965daf5ceb3cb7fd6152' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4240b570080eddbfc8eb3e319c9992c7' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Gene expression profiling of RNA from peripheral blood mononuclear cells, tumor tissue, and/or body fluid cells. [ Time Frame: Throughout treatment ] [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:4240b570080eddbfc8eb3e319c9992c7' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:629ce9e4905c5571c535cc5c4588fac1' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Serum concentrations of hepatocyte growth factor (HGF)/SCH 900105 complex. [ Time Frame: Throughout treatment ] [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:629ce9e4905c5571c535cc5c4588fac1' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:dbbc7c6370383e074038c7dee168792d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Standardized uptake value measured by positron-emission tomography scan. [ Time Frame: Screening Visit and Cycle 3 Day 1. ] [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:dbbc7c6370383e074038c7dee168792d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2eff824ab77350bd698f5df0a3299305' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Serum concentrations of exploratory biomarkers (HGF, s-Met, angiogenic and inflammation markers). [ Time Frame: Throughout treatment ] [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:2eff824ab77350bd698f5df0a3299305' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:352d70193ede05ded78f86e5a49c20d4' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: A donor peripheral stem cell transplant helps stop the growth of cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient\'s bone marrow make stem cells, red blood cells, white blood cells, and platelets. Once the donated stem cells begin working, the patient\'s immune system may see the remaining cancer cells as not belonging in the patient\'s body and destroy them. Giving an infusion of donor T cells may helps stop the patient\'s immune system from rejecting the donor\'s stem cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of donor T cells in treating patients with high-risk hematologic cancer who are undergoing donor peripheral blood stem cell transplant.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:352d70193ede05ded78f86e5a49c20d4' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e5186cd5855132b57983e764d3b6af1b' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'MT2004-03: A Clinical Trial of Adult CD4+ CD25+ Regulatory T Cells in BMT Recipients Was "A Dose Escalation Study of CD4+ CD25+ Cells in Adult Patients Undergoing HLA-Identical Sibling Donor Peripheral Blood Progenitor Cell (PBPC) Transplantation&quo\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:e5186cd5855132b57983e764d3b6af1b' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:88cc5b5198290b5cc0e09b556cb0785e' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES: Primary\n<ul>\n<li>To determine whether CD4- and CD25-positive regulatory T cells can be safely administered to patients with high-risk hematologic malignancies undergoing HLA-identical sibling donor peripheral blood progenitor cell (PBPC) transplantation.</li>\n</ul>\n Secondary\n<ul>\n<li>To determine the incidence of grade II-IV acute graft-versus-host-disease (GVHD), chronic GVHD, relapse, and survival after administration of CD4- and CD25-positive regulatory T cells in these patients.</li>\n</ul>\n OUTLINE: This is a dose-escalation study of CD4- and CD25-positive donor regulatory T cells followed by a phase II study. All patients receive myeloablative preparative therapy and GVHD prophylaxis as per University of Minnesota protocol UMN-MT2001-02 or UMN-MT2001-10.\n<ul>\n<li>First allogeneic peripheral blood progenitor cell (PBPC) infusion: Patients receive unmobilized, culture-expanded, CD4- and CD25-positive donor regulatory T cells IV over 15-60 minutes at the assigned dose on day -2.</li>\n<li>Second allogeneic PBPC infusion: Patients undergo matched-sibling donor PBPC transplantation IV on day 0.</li>\n</ul>\n Patients undergo blood sample collection prior to commencement of preparative therapy and then at day 100, 6 months, and 1 year after PBPC transplantation. Samples are analyzed for immune reconstitution by immunophenotyping and functional analyses. After completion of study therapy, patients are followed for up to 1 year.\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:88cc5b5198290b5cc0e09b556cb0785e' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cf0204f2091e71d9a29007de741d118d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Diagnosis of a high-risk hematologic malignancy, including any of the following:\n<ul>\n<li>Acute lymphoblastic leukemia (ALL) beyond second complete remission (CR2)</li>\n<li>Acute myeloid leukemia beyond CR2</li>\n<li>Chronic myelogenous leukemia in accelerated phase or post-blast crisis</li>\n<li>Myelodysplastic syndromes with 5-20% blasts in bone marrow</li>\n<li>Non-Hodgkin lymphoma beyond third partial remission</li>\n<li>Multiple myeloma meeting the following criterion:\n<ul>\n<li>Not a candidate for autologous stem cell transplantation</li>\n</ul>\n</li>\n</ul>\n</li>\n<li>Must have an HLA-identical sibling donor available, meeting the following criteria:\n<ul>\n<li>12 to 75 years of age</li>\n<li>Matched to recipient for HLA-A and -B antigens using serological techniques and for DRB1 allele level using SSOP typing UMN-MT2001-02</li>\n</ul>\n</li>\n<li>Concurrently enrolled on 1 of the following protocols:\n<ul>\n<li>UMN-MT2001-02</li>\n<li>UMN-MT2001-10</li>\n</ul>\n</li>\n</ul>\n PATIENT CHARACTERISTICS:\n<ul>\n<li>Not specified</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n</ul>\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:cf0204f2091e71d9a29007de741d118d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:955254cde948984eb9e60ebac1471e8a' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Disease-free survival [ Designated as safety issue: No ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:955254cde948984eb9e60ebac1471e8a' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1e8c637579fde6f0fcb8a2651fdb18a9' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Maximum tolerated dose (Phase I) [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:1e8c637579fde6f0fcb8a2651fdb18a9' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:304374ea3ca2a087b59d8e9d97059a92' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence of grade 3-5 infusional toxicity at 48 hours after a CD4- and CD25-positive regulatory T-cell infusion (phase II) [ Designated as safety issue: Yes ]\n', created = 1283569470, expire = 1283655870, headers = '', serialized = 0 WHERE cid = '1:304374ea3ca2a087b59d8e9d97059a92' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c23c82efd2f0577ba704d51488708c2e' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Cumulative incidence of grade II-IV acute graft-versus-host-disease (GVHD) at day 100 [ Designated as safety issue: Yes ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:c23c82efd2f0577ba704d51488708c2e' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4e3050674aeef45c053bbe3dc185e71a' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Incidence of chronic GVHD at 6 months [ Designated as safety issue: Yes ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:4e3050674aeef45c053bbe3dc185e71a' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3742cbea75676c7d2a67a4ff75040626' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Relapse at 6 months [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:3742cbea75676c7d2a67a4ff75040626' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:eec69a9d1c23f750a0cbcc0bd1a4d41f' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Survival at 100 days and 1 year [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:eec69a9d1c23f750a0cbcc0bd1a4d41f' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:81943028a4b3a3d0d6ce193a4354f052' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'The first part of the study will determine the highest dose of study drug that can be taken without causing serious side effects in patients with lymphoma. The appropriate dose determined from the first part of the study will be used in the second part of the study to assess disease response in 6 different types of lymphoma patients.\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:81943028a4b3a3d0d6ce193a4354f052' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4075d51967a34c1725f43cfd538f763a' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: PEG-interferon alfa-2b may interfere with the growth of cancer cells and slow the growth of mycosis fungoides/Sezary syndrome. Ultraviolet light therapy uses a drug, such as psoralen, that is absorbed by cancer cells. The drug becomes active when it is exposed to ultraviolet light. When the drug is active, cancer cells are killed. Giving PEG-interferon alfa-2b together with ultraviolet light therapy may kill more cancer cell. PURPOSE: This clinical trial is studying the side effects and best dose of PEG-interferon alfa-2b when given together with ultraviolet light therapy in treating patients with stage IB, stage II, stage III, or stage IVA mycosis fungoides/Sezary syndrome.\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:4075d51967a34c1725f43cfd538f763a' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4e16f03346b44b28dc5b5c8db1e32fce' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Pilot Study of Pegylated Interferon-Alfa 2b in Combination With PUVA Therapy in Cutaneous T-Cell Lymphoma\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:4e16f03346b44b28dc5b5c8db1e32fce' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:dde542e8cf83c1fcd611c07828e4ffd8' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES: Primary\n<ul>\n<li>To evaluate toxicity, patient self-reported disease and treatment-related symptoms, and the impact of treatment on quality of life of combined pegylated interferon alfa-2b (IFN-α-2b) and psoralens with ultraviolet light A (PUVA) therapy on health-related quality of life in patients with stages IB-IVA mycosis fungoides/Sezary syndrome.</li>\n</ul>\n Secondary\n<ul>\n<li>To evaluate efficacy and duration of response related to combined pegylated IFN-α-2b plus PUVA therapy in these patients.</li>\n</ul>\n OUTLINE: This is an intrapatient dose-escalation study of PEG-interferon alfa-2b. Patients receive PEG-interferon alfa-2b subcutaneously once weekly for 12 months in the absence of disease progression or unacceptable toxicity. Patients also receive oral psoralen 1.5-2 hours prior to ultraviolet light A treatment. Treatment with UV light therapy repeats 2-3 times weekly until complete remission is achieved and then once every 4-6 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity. Health-related quality of life is assessed periodically using the FACT-BRM, FACT-G, and FACT-CTCL questionnaires. After completion of study therapy, patients are followed for 1 year.\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:dde542e8cf83c1fcd611c07828e4ffd8' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:051c24d38918d040a534563221a3cd81' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed mycosis fungoides/Sezary syndrome\n<ul>\n<li>Stage IB-IVA disease</li>\n<li>Erythrodermic disease allowed</li>\n</ul>\n</li>\n<li>Measurable disease\n<ul>\n<li>One or more indicatory lesions must be designated prior to study entry</li>\n</ul>\n</li>\n</ul>\n PATIENT CHARACTERISTICS:\n<ul>\n<li>ECOG/WHO performance status 0-1</li>\n<li>Life expectancy ≥ 3 months</li>\n<li>Absolute neutrophil count ≥ 1,500/mm³</li>\n<li>Platelet count ≥ 75,000/mm³</li>\n<li>WBC ≥ 3,000/mm³</li>\n<li>Serum creatinine ≤ 2.0 mg/dL</li>\n<li>Total serum bilirubin ≤ 2.2 mg/dL</li>\n<li>Serum AST and ALT ≤ 2 times upper limit of normal</li>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test</li>\n<li>Fertile patients must use effective contraception</li>\n<li>Patients must be disease free of prior malignancies for ≥ 5 years except currently treated squamous cell or basal cell carcinoma of the skin, carcinoma in situ of the cervix, or surgically removed melanoma in situ of the skin (stage 0), with histologically confirmed free margins of excision</li>\n<li>No history of seizure disorder or severe heart disease</li>\n<li>No acute infections</li>\n<li>Diagnosed depression allowed with receiving appropriate care for depression</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>No prior psoralens with ultraviolet light A or interferon alfa therapy</li>\n<li>More than 4 weeks since prior topical therapy, systemic chemotherapy, or biologic therapy</li>\n<li>More than 4 weeks since prior surgery and fully recovered</li>\n<li>At least 1 week since prior antibiotics</li>\n<li>No other concurrent standard or investigational topical and systemic antipsoriatic or anticancer therapies including radiation, steroids, retinoids, nitrogen mustard, thalidomide, or other investigational agents</li>\n<li>No concurrent topical agents except emollients</li>\n</ul>\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:051c24d38918d040a534563221a3cd81' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e760e13ccf51ba2a55bfe1ce9261f68a' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Toxicity [ Designated as safety issue: Yes ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:e760e13ccf51ba2a55bfe1ce9261f68a' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f2bf6dd49311399fa3e6884fca9fbb40' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Efficacy [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:f2bf6dd49311399fa3e6884fca9fbb40' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Health-related quality of life [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:f87d16f050a79b48f3196d4bac556711' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6713644cfb7a461772facea017cb04a1' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Patient self-reported disease [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:6713644cfb7a461772facea017cb04a1' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Treatment-related symptoms [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:b186078c5efb6855388efa0b1209abe7' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:49c2ff260a75ba3c1b04a91d0b345203' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Duration of response [ Designated as safety issue: Yes ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:49c2ff260a75ba3c1b04a91d0b345203' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fd05b5e100c550ae2ff5470953cfbabb' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Sometimes the cancer may not need treatment until it progresses. In this case, observation may be sufficient. Giving combination chemotherapy together with bortezomib, thalidomide, and rituximab before an autologous peripheral stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as G-CSF, helps stem cells move from the bone marrow to the blood so they can be collected and stored. More chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. PURPOSE: This observational and phase II trial is studying how well giving combination chemotherapy together with bortezomib, thalidomide, and rituximab followed by two autologous peripheral blood stem cell transplants works in treating patients with Waldenstrom macroglobulinemia.\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:fd05b5e100c550ae2ff5470953cfbabb' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Toxicity [ Designated as safety issue: Yes ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:e760e13ccf51ba2a55bfe1ce9261f68a' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Overall survival [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Response rate (complete response, very good partial response, and partial response) [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:4c09f8061c1dbd87c131f89f001abfef' in /persistent/html/includes/cache.inc on line 109.
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user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Standard prognostic factors and other potential correlates that may relate to progression, symptomatic disease, and/or survival [ Designated as safety issue: No ]\n', created = 1283569471, expire = 1283655871, headers = '', serialized = 0 WHERE cid = '1:6d970013327ebe98a1ec9016f6279787' in /persistent/html/includes/cache.inc on line 109.

Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell Transplant

Trial phase:

Phase II

Recruitment status:

Not yet recruiting

RATIONALE: Palifermin may help relieve or prevent oral mucositis caused by chemotherapy and radiation therapy in young patients undergoing stem cell transplant. PURPOSE: This randomized phase II trial is studying palifermin to see how well it works compared with a placebo in preventing oral mucositis caused by chemotherapy and/or radiation therapy in young patients undergoing stem cell transplant.

Background information

Trial ID:

NCT00728585

Other unique IDs:

CDR0000588622

COG-ACCL0521

Official title:

A Group-Wide Double-Blind Randomized Placebo-Controlled Trial of Palifermin to Prevent Chemotherapy and/or Radiotherapy Induced Oral Mucositis in Children Undergoing Autologous or Allogeneic Hematopoietic Stem Cell Transplantation

Detailed description:

OBJECTIVES: Primary

To compare whether palifermin versus placebo administered to pediatric patients three days prior to conditioning and three days after autologous or allogeneic hematopoietic stem cell transplantation (HSCT) is associated with a reduction in the incidence of WHO grade 3 or 4 oral mucositis.

Number to be enrolled:

200 patients

Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma

RATIONALE: Drugs used in chemotherapy, such as methotrexate and leucovorin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Glucarpidase may help return the level of methotrexate in the blood to a safe range. Giving high-dose methotrexate together with glucarpidase and leucovorin may kill more cancer cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of methotrexate when given together with glucarpidase and leucovorin in treating patients with newly diagnosed primary central nervous system lymphoma.

Background information

Other unique IDs:

CDR0000599206

CRUK-BRD/07/004

2007-002570-58

EU-20861

Everolimus in Treating Older Patients With Mantle Cell Lymphoma Previously Treated With First-Line or Second-Line Chemotherapy

Trial phase:

Phase II

Recruitment status:

Recruiting

RATIONALE: Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well everolimus works in treating older patients with mantle cell lymphoma who received previous first-line or second-line chemotherapy.

Background information

Trial ID:

NCT00727207

Other unique IDs:

CDR0000597004

KRDI-TUM-CRAD001C2428

EUDRACT: 2007-005116-12

EU-20855

Official title:

Phase II Trial on Efficacy of mTOR Inhibitor RAD001 as Maintenance Therapy for Patients Above 60 Years in Mantle Cell Lymphoma After First and Second Line Chemotherapy

Detailed description:

OBJECTIVES: Primary

Determine the progression-free survival of older patients with mantle cell lymphoma receiving everolimus and who were previously treated with first- or second-line chemotherapy.

Secondary

Determine the toxicity and feasibility of treatment with this drug.
Determine the efficacy of this drug in these patients.
Compare the duration of remission after first- vs second-line chemotherapy.
Determine the rate of objective remission.

Number to be enrolled:

35 patients

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

Recruitment status:

Recruiting

RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.

Background information

Trial ID:

NCT00726830

Other unique IDs:

CDR0000598283

MDA-2007-0791

Official title:

A Randomized Comparison of Oral Methadone as a "First-Switch" Opioid Versus Opioid Switching Between Sustained-Release Morphine and Oxycodone for Oncology-Hematology Outpatients With Pain Management Problems: The "Simply Rotate" Study

Detailed description:

OBJECTIVES: Primary

To compare the effectiveness of an opioid rotation to oral methadone versus an opioid rotation to another long-acting strong opioid (sustained-release morphine or oxycodone) in controlling pain (i.e., analgesia) in patients with cancer.

Number to be enrolled:

300 patients

Pegfilgrastim and Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Aggressive B-Cell Non-Hodgkin Lymphoma

RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, and vincristine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Colony-stimulating factors, such as pegfilgrastim, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of chemotherapy. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. It is not yet known whether combination chemotherapy and pegfilgrastim is more effective when given with or without rituximab in treating non-Hodgkin lymphoma. PURPOSE: This phase II trial is studying the side effects of giving pegfilgrastim and combination chemotherapy together with or without rituximab and to see how well it works in treating older patients with aggressive B-cell non-Hodgkin lymphoma.

Background information

Other unique IDs:

CDR0000454473

DSHNHL-2003-2

EU-20534

A Phase 1 Dose-Escalation Study in Advanced Solid Tumors and Lymphomas (Study P05538)

The primary objective of this study is to determine safety, tolerability, dose-limiting toxicities and recommended dose of SCH 900105 administered intravenously (IV) to subjects with relapsed or refractory solid tumors or lymphoma.

Background information

Other unique IDs:

P05538

Donor T Cells in Treating Patients With High-Risk Hematologic Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant

Trial phase:

Phase I

Recruitment status:

Recruiting

RATIONALE: A donor peripheral stem cell transplant helps stop the growth of cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Once the donated stem cells begin working, the patient's immune system may see the remaining cancer cells as not belonging in the patient's body and destroy them. Giving an infusion of donor T cells may helps stop the patient's immune system from rejecting the donor's stem cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of donor T cells in treating patients with high-risk hematologic cancer who are undergoing donor peripheral blood stem cell transplant.

Background information

Trial ID:

NCT00725062

Other unique IDs:

CDR0000601051

UMN-2004LS034

MT2004-03

Official title:

MT2004-03: A Clinical Trial of Adult CD4+ CD25+ Regulatory T Cells in BMT Recipients Was "A Dose Escalation Study of CD4+ CD25+ Cells in Adult Patients Undergoing HLA-Identical Sibling Donor Peripheral Blood Progenitor Cell (PBPC) Transplantation&quo

Detailed description:

OBJECTIVES: Primary

To determine whether CD4- and CD25-positive regulatory T cells can be safely administered to patients with high-risk hematologic malignancies undergoing HLA-identical sibling donor peripheral blood progenitor cell (PBPC) transplantation.

Secondary

To determine the incidence of grade II-IV acute graft-versus-host-disease (GVHD), chronic GVHD, relapse, and survival after administration of CD4- and CD25-positive regulatory T cells in these patients.

Number to be enrolled:

32 patients

Study of the Safety and Tolerability of PCI-24781 in Patients With Lymphoma

The first part of the study will determine the highest dose of study drug that can be taken without causing serious side effects in patients with lymphoma. The appropriate dose determined from the first part of the study will be used in the second part of the study to assess disease response in 6 different types of lymphoma patients.

Background information

Other unique IDs:

PCYC-0403

PEG-Interferon Alfa-2b and Ultraviolet Light Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Mycosis Fungoides/Sezary Syndrome

Recruitment status:

Recruiting

RATIONALE: PEG-interferon alfa-2b may interfere with the growth of cancer cells and slow the growth of mycosis fungoides/Sezary syndrome. Ultraviolet light therapy uses a drug, such as psoralen, that is absorbed by cancer cells. The drug becomes active when it is exposed to ultraviolet light. When the drug is active, cancer cells are killed. Giving PEG-interferon alfa-2b together with ultraviolet light therapy may kill more cancer cell. PURPOSE: This clinical trial is studying the side effects and best dose of PEG-interferon alfa-2b when given together with ultraviolet light therapy in treating patients with stage IB, stage II, stage III, or stage IVA mycosis fungoides/Sezary syndrome.

Background information

Trial ID:

NCT00724061

Other unique IDs:

CDR0000598495

NU-07H4

SPRI-NU-07H4

Official title:

Pilot Study of Pegylated Interferon-Alfa 2b in Combination With PUVA Therapy in Cutaneous T-Cell Lymphoma

Detailed description:

OBJECTIVES: Primary

To evaluate toxicity, patient self-reported disease and treatment-related symptoms, and the impact of treatment on quality of life of combined pegylated interferon alfa-2b (IFN-α-2b) and psoralens with ultraviolet light A (PUVA) therapy on health-related quality of life in patients with stages IB-IVA mycosis fungoides/Sezary syndrome.

Secondary

To evaluate efficacy and duration of response related to combined pegylated IFN-α-2b plus PUVA therapy in these patients.

Number to be enrolled:

15 patients

Observation or Combination Chemotherapy, Bortezomib, Thalidomide, and Rituximab Followed By Two Autologous Peripheral Blood Stem Cell Transplants in Treating Patients With Waldenstrom Macroglobulinemia

RATIONALE: Sometimes the cancer may not need treatment until it progresses. In this case, observation may be sufficient. Giving combination chemotherapy together with bortezomib, thalidomide, and rituximab before an autologous peripheral stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as G-CSF, helps stem cells move from the bone marrow to the blood so they can be collected and stored. More chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. PURPOSE: This observational and phase II trial is studying how well giving combination chemotherapy together with bortezomib, thalidomide, and rituximab followed by two autologous peripheral blood stem cell transplants works in treating patients with Waldenstrom macroglobulinemia.

Background information

Other unique IDs:

CDR0000600963

SWOG-S0629

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Pegfilgrastim and Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Aggressive B-Cell Non-Hodgkin Lymphoma

A Phase 1 Dose-Escalation Study in Advanced Solid Tumors and Lymphomas (Study P05538)

Donor T Cells in Treating Patients With High-Risk Hematologic Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant

Study of the Safety and Tolerability of PCI-24781 in Patients With Lymphoma

PEG-Interferon Alfa-2b and Ultraviolet Light Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Mycosis Fungoides/Sezary Syndrome

Observation or Combination Chemotherapy, Bortezomib, Thalidomide, and Rituximab Followed By Two Autologous Peripheral Blood Stem Cell Transplants in Treating Patients With Waldenstrom Macroglobulinemia

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