Gastric Cancer

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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with colorectal, gastric, ovarian, breast or lung epithelial cancer. Tumor cells grown in the laboratory will be modified to make them stimulatory to the immune system, irradiated to kill them, and injected to the patient eight times at two-week intervals . This protocol is expected to prolong survival of metastatic epithelial cancer patients.</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:5650289547ee540364ac5715ce9953b8' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Metastatic epithelial cancer</li>\n<li>Above 18 years of age</li>\n<li>Failure of at least one chemotherapy protocol</li>\n<li>Clinical performance status of ECOG 0,1</li>\n<li>Absolute neutrophil count greater than 1000/mm3</li>\n<li>Serum ALT/AST less than three times the upper limit of normal</li>\n<li>Serum creatinine less than or equal to 1.6 mg/dl.</li>\n<li>Must be able to understand and sign the Informed Consent document</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Below 18 years of age</li>\n<li>Women who are pregnant</li>\n<li>Life expectancy of less than three months</li>\n</ul>\n</p>', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:52d0208a94ed93feaea61fa51f692e38' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Study Phase: 1b/2 Indication: Previously untreated subjects with unresectable locally advanced or metastatic gastric or esophagogastric junction adenocarcinoma. Primary Objective(s): Part 1: To identify safe dose levels of AMG 102, up to 15 mg/kg Q3W, to combine with ECX. Part 2 (phase 2-double-blind): To estimate with pre-specified precision the effect of the addition of AMG 102 to ECX on progression free survival (PFS).</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:044acdd0e44efed04a6cf048ef332a26' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Multicenter, Double-Blind, 3-Arm, Phase 1b/2 Study in Subjects With Unresectable Locally Advanced or Metastatic Gastric or Esophagogastric Junction Adenocarcinoma to Evaluate the Safety and Efficacy of First-Line Treatment With Epirubicin, Cisplatin, an</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:a6cc8a32230716f88f2877b85622e238' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Pathologically confirmed unresectable locally advanced or metastatic gastric or esophagogastric junction (EGJ) adenocarcinoma; tumors of the distal esophagus within 5 cm of the EGJ are eligible</li>\n<li>ECOG performance status 0 or 1</li>\n<li>Male or female &#8805; 18 years of age</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Previous systemic therapy (chemotherapy or biologic therapy) for locally advanced or metastatic gastric or esophagogastric adenocarcinoma</li>\n<li>Less than 6 months have elapsed from completion of prior neoadjuvant or adjuvant chemotherapy or chemoradiotherapy.</li>\n<li>Subjects with resectable disease or suitable for definitive chemoradiation</li>\n<li>Subjects with persistent gastric outlet obstruction, complete dysphagia or feeding jejunostomy</li>\n<li>Tumors of squamous cell histology</li>\n<li>Known central nervous system metastases</li>\n<li>Clinically significant upper gastro-intestinal bleeding &#8804; 30 days prior to enrollment or randomization</li>\n<li>Serious or non-healing wound</li>\n</ul>\n</p>', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:34c0a478f8388c35639fa14f514d8ca7' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study will determine the feasibility of adjuvant chemotherapy and chemo-radiotherapy for patients with surgically resected adenocarcinoma of the stomach and gastro-esophageal junction.</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:6f8531653b1beb83e7ddc70a4bf8fae2' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase II Trial of Postoperative Chemotherapy and Chemo-Radiotherapy for Resected Adenocarcinoma of the Stomach and Gastro-Esophageal Junction</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:84d00fcfd1c86913adf538cea62cbe0a' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Patients with localized gastric cancer often relapse either locally or systemically. A strategy to reduce relapses at common sites would be beneficial. Our prior trial has proved the feasibility of administering FOLFIRI regimen as adjuvant chemotherapy combined with adjuvant chemoradiation in patients with excised with curative intend gastric cancer. It would be important to improve the treatment involving active regimen as adjuvant chemotherapy and optimizing chemoradiation by introducing capecitabine as a radiosensitizer.</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:34f2262bb85a354465c85cee6974bf5d' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Patients with radically resected adenocarcinoma of the stomach and/or gastroesophageal junction with histologic proof of adenocarcinoma, pathologically staged T2-3, any N, M0</li>\n<li>No prior radiation therapy to the stomach or immunotherapy or chemotherapy for any reason</li>\n<li>Patients must have a life expectancy of at least 16 weeks and a performance status of &lt; 2 ECOG scale</li>\n<li>Previous adjuvant chemotherapy with Irinotecan, Oxaliplatin and/or 5-FU based regimen. Patients who relapse within the first 6 months after the completion of adjuvant treatment are not eligible for the study.</li>\n<li>Patients must have adequate bone marrow function (defined as peripheral absolute granulocyte count of &gt; 2.000/&#181;L, and platelet count of &gt; 100.000/&#181;L), adequate liver function (bilirubin &lt; 1,5 mg/dl), and adequate renal function (creatinine &lt; 1,5 mg/dl</li>\n<li>Patients must be able to understand the nature of this study and give written informed consent</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Patients with T1N0 carcinoma</li>\n<li>Positive cytology of pleural, or pericardial effusion or patients with any peritoneal disease diagnosed intra-operatively)</li>\n<li>Biopsy proof of lymph node metastases outside the study field such as supraclavicular, mediastinal, or para-aortic nodes</li>\n<li>Evidence of metastatic disease to distant organs</li>\n<li>Patients with cardiac disease graded as New York Heart Association Class III or IV, severe uncontrolled diabetes, hypertension, cerebron-vascular disease, or infection</li>\n<li>Patients with diabetic neuropathy</li>\n<li>Abnormalities of mental status such that either the patient cannot fully comprehend the therapeutic implications of the protocol or comply with the requirements</li>\n<li>Presence of concurrent or previous malignancies in the past 5 years (except for resected squamous or basal cell carcinoma of the skin)</li>\n<li>Pregnant women are excluded from study entry due to the teratogenic effects of the study treatment</li>\n</ul>\n</p>', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:504a2b5b9c7918d2c673a67134b7515e' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Overall survival [&nbsp;Time&nbsp;Frame:&nbsp;1 year&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:c05c0158ea62d2c91ffd4aab3d71720c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Toxicity profile [&nbsp;Time&nbsp;Frame:&nbsp;Toxicity assessment on each chemotherapy cycle&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:6fc151fc566f32a69ab98b2842b768ce' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Due to evidence available both in terms of efficacy and safety of low molecular weight heparin, its use for the prevention of thromboembolic disease in cancer patients undergoing surgical intervention, and its extended use in higher doses for the prevention of recurrent thromboembolism in cancer patients with established thrombosis, with a view that the potential benefits for survival in cancer patients from low molecular weight heparin therapy comes because of a biological activity, the dose of 1mg/Kg (50% of the full treatment dose) for a period of 6 months coincident with 6 cycles of chemotherapy, has been chosen for this study.</p>\n', created = 1283940109, expire = 1284026509, headers = '', serialized = 0 WHERE cid = '1:2d0d059b9580c624951349366adf6792' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Drugs used in chemotherapy, such as docetaxel, oxaliplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of docetaxel when given with oxaliplatin and fluorouracil and to see how well they work in treating patients with metastatic or unresectable stomach cancer, gastroesophageal junction cancer, or other solid tumor.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:fb27004e34948cacdfd8421c97ff2898' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase I/II Study of Taxotere, Oxaliplatin, and 5- Fluorouracil</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:629df973dc2683337d531c01ec5a2033' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES: Primary\n<ul>\n<li>To establish the maximum tolerated dose of docetaxel when administered with oxaliplatin and fluorouracil in patients with metastatic or unresectable solid tumors. (Phase I)</li>\n<li>To determine the response rate in patients with metastatic or unresectable adenocarcinoma of the stomach or gastroesophageal junction treated with this regimen. (Phase II)</li>\n</ul>\n</p><p> Secondary\n<ul>\n<li>To determine the dose limiting toxicity of this regimen in these patients.</li>\n<li>To evaluate the frequency of CYP3A4, CYP3A5, and MDR polymorphisms and their impact on toxicity of docetaxel.</li>\n<li>To evaluate the frequency of XRCC1 and ERCC2 polymorphisms and their impact on the toxicity of oxaliplatin.</li>\n<li>To evaluate the frequency of DPD and TSER polymorphisms and their impact on the toxicity of fluorouracil.</li>\n<li>To characterize the toxicity profile of this regimen in these patients.</li>\n</ul>\n</p><p> OUTLINE: This is a dose-escalation study of docetaxel. Patients receive docetaxel IV over 1 hour and oxaliplatin IV over 2 hours on day 1 and fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 14 days for at least 2 courses in the absence of disease progression, symptomatic tumor progression, or unacceptable toxicity. Patients undergo blood sample collection periodically for pharmacokinetic and pharmacogenomic correlative studies. Plasma concentrations of docetaxel are analyzed by reverse-phase high performance liquid chromatography and tandem mass spectrometry. Polymorphisms in CYP3A4/5, MDR, and other genes are analyzed by PCR. After completion of study therapy, patients are followed every 3 months. PROJECTED ACCRUAL: A total of 73 patients (30 for phase I and 43 for phase II) will be accrued for this study.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:3e762b533d19d688f61dff1f683f9897' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed metastatic or surgically unresectable solid tumor meeting 1 of the following criteria:\n<ul>\n<li>Any solid tumor (Phase I)</li>\n<li>Adenocarcinoma of the stomach or gastroesophageal junction (Phase II)</li>\n</ul>\n</li>\n<li>Unidimensionally measurable disease by CT scan or MRI</li>\n<li>No uncontrolled brain metastasis</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>ECOG performance status 0-1</li>\n<li>ANC &#8805; 1,500/mm&#179;</li>\n<li>Platelet count &#8805; 100,000/mm&#179;</li>\n<li>Hemoglobin &#8805; 8.0 g/dL</li>\n<li>Creatinine &#8804; 1.5 times upper limit of normal (ULN)</li>\n<li>Total bilirubin normal</li>\n<li>Meets 1 of the following criteria:\n<ul>\n<li>Alkaline phosphatase (AP) normal AND AST or ALT &#8804; 5 times ULN</li>\n<li>AP &#8804; 2.5 times ULN AND AST or ALT &#8804; 1.5 times ULN</li>\n<li>AP &#8804; 5 times ULN AND AST or ALT normal</li>\n</ul>\n</li>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test</li>\n<li>Fertile patients must use effective contraception during and for &#8805; 3 months after completion of study therapy</li>\n<li>No preexisting neuropathy</li>\n<li>No concurrent uncontrolled illness or other condition that would preclude study compliance</li>\n<li>No history of severe hypersensitivity reaction to docetaxel or to other drugs formulated with polysorbate 80</li>\n<li>No history of allergic reactions attributed to compounds of similar chemical or biologic composition to agents used in this study</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>Recovered from prior therapy</li>\n<li>More than 4 weeks since prior therapy (Phase I)</li>\n<li>No prior oxaliplatin or taxanes (Phase I)</li>\n<li>More than 4 weeks since prior radiotherapy (Phase I)</li>\n<li>No more than two prior therapies for metastatic disease (Phase I)</li>\n<li>No prior therapy for metastatic disease (Phase II)</li>\n<li>At least 6 months since prior adjuvant therapy (given prior to the occurrence of metastatic disease) (Phase II)</li>\n<li>Prior fluorouracil and concurrent radiotherapy for palliation of the primary tumor allowed provided metastatic disease is present outside the radiotherapy field (Phase II)</li>\n<li>No prior radiotherapy to &#8805; 30% of bone marrow</li>\n<li>No other concurrent investigational agents</li>\n</ul>\n</p>', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:cfe76dc1a11603bd5bc2c7f2d4997372' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Maximum tolerated dose of docetaxel when given in combination with oxaliplatin and fluorouracil in patients with solid tumors (Phase I) [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:313d5e8ab63735d05891634aba31280c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Response rate in patients with adenocarcinoma of the stomach or gastroesophageal junction (Phase II) [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:5a3e6f454979fd726225d1c64ccbe492' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Dose-limiting toxicity of docetaxel when given in combination with oxaliplatin and fluorouracil [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:6ebe77c2266651d73d0005151b1b5bdf' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of CYP3A4, CYP3A5, and MDR polymorphisms and their impact on docetaxel toxicity [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:af2862a5ebdf520e0db32297c10a7ad0' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of XRCC1 and ERCC2 polymorphisms and their impact on oxaliplatin toxicity [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:423f49a02e0c07d8905d8f25a6fce325' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:789eebeb7636c688f69a45b69ae3dd6c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Frequency of DPD and TSER polymorphisms and their impact on fluorouracil toxicity [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:789eebeb7636c688f69a45b69ae3dd6c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7e72a885559ec5625275c28d7c6f8bfb' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Providing cognitive and behavioral therapy may improve the well-being and quality of life of patients with advanced cancer. PURPOSE: This randomized clinical trial is studying cognitive and behavioral therapy to see how well it works compared with standard care in treating patients with advanced gastrointestinal cancer or lung cancer.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:7e72a885559ec5625275c28d7c6f8bfb' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6e5b6c7c8c1bb75aab4a1ff11f998e9b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Brief CBT for Anxiety and Advanced Cancer</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:6e5b6c7c8c1bb75aab4a1ff11f998e9b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:976f418d13c4af544180cc40aca49ccf' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES:\n<ul>\n<li>To develop and examine the feasibility and patient acceptability of administering a manualized cognitive-behavioral intervention that improves quality of life by treating anxiety in patients with advanced gastrointestinal cancer or lung cancer.</li>\n<li>To estimate the effect size of a manualized cognitive-behavioral intervention to reduce anxiety in patients with advanced lung or gastrointestinal cancer.</li>\n<li>To estimate the effect size for the secondary outcomes (i.e., depression and quality of life) and to examine the extent to which specific variables (i.e., sex, age, chemotherapy side effects, pain levels) are consistent with the conceptual model as potential moderators of treatment effect.</li>\n</ul>\n</p><p> OUTLINE: This is a pilot study followed by a randomized study. Patients are stratified according to type of cancer (liver, bile duct, gall bladder, and pancreatic vs second-line colorectal, gastric, and esophageal vs lung).\n<ul>\n<li>Pilot study: Patients complete qualitative interviews to explore ways that anxiety impacts patients, to identify components of a cognitive-behavioral therapy intervention that are most useful, and to determine the optimal method of delivery for the intervention (e.g., number and timing of interventions, administration during chemotherapy infusions when feasible). Based upon these results a full treatment manual is written for use in the randomized study. Patients are then randomized to 1 of 2 treatment arms.</li>\n<li>Arm I (cognitive-behavioral therapy): Patients undergo six 90-minute treatment modules (over 2 months) based on the results of the pilot study.</li>\n</ul>\n</p><p> Modules include psychoeducation and motivational interviewing; relaxation training and mindfulness practice; cognitive restructuring; coping with cancer fears; activity planning and pacing; and review, termination, and plan for continued use of skills.\n<ul>\n<li>Arm II (routine care): Patients receive routine medical care. At the completion of treatment, all patients meet with a blinded independent assessor to assess outcomes. Patients undergo psychiatric evaluation, including the Hamilton Anxiety Rating Scale (HAM-A), the Montgomery Asberg Depression Rating Scale (MADRS), the Mini International Neuropsychiatric Interview (MINI), and a psychosocial self-reported battery at baseline and 3 months after completing therapy.</li>\n</ul>\n</p><p> After completing treatment, patients who underwent routine care (arm II) may undergo cognitive-behavioral therapy as in arm I, if desired.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:976f418d13c4af544180cc40aca49ccf' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6dff962701910c582f812b7fc3269f6e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Diagnosis of any of the following:\n<ul>\n<li>Stage IIIB (with effusions) or IV non-small cell lung cancer</li>\n<li>Extensive stage small cell lung cancer</li>\n<li>Solid gastrointestinal cancer\n<ul>\n<li>Nonresectable</li>\n<li>Not being treated for curative intent</li>\n<li>Including any of the following diagnoses:\n<ul>\n<li>Stage III or IV pancreatic cancer</li>\n<li>Stage IV liver cancer</li>\n<li>Stage III or IV gallbladder cancer</li>\n<li>Stage III or IV bile duct cancer</li>\n<li>Stage IVB esophageal cancer</li>\n<li>Stage IV gastric cancer</li>\n</ul>\n</li>\n</ul>\n</li>\n<li>Second-line colorectal cancer (stage IV after a first line of chemotherapy)</li>\n</ul>\n</li>\n<li>At least four weeks post-diagnosis</li>\n<li>Current symptoms of anxiety and anxiety as principal psychiatric problem\n<ul>\n<li>Patients with co-morbid depression are eligible as long as anxiety symptoms are primary</li>\n</ul>\n</li>\n<li>Undergoing chemotherapy</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>No delirium or dementia</li>\n<li>No active and untreated major psychiatric condition such as schizophrenia or bipolar disorder, other psychotic disorders, or substance dependence</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>Concurrent pharmacotherapy for anxiety allowed</li>\n</ul>\n</p>', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:6dff962701910c582f812b7fc3269f6e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0b8797bdbc5a54169eb9de5bd9c8b560' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Depression as measured by the Montgomery Asberg Depression Rating Scale [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:0b8797bdbc5a54169eb9de5bd9c8b560' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0701b883ca05c32f8fe68b4ce3c26656' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Quality of life as measured by the Functional Assessment of Scale Cancer Therapy [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:0701b883ca05c32f8fe68b4ce3c26656' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:09470d0f16f5b94aeec4fab8ccb18974' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Functional impairment as measured by the Sheehan Disability Scale and the Global Assessment of Functioning [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:09470d0f16f5b94aeec4fab8ccb18974' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:40ce3944b498984f354888ac2f306b0e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to evaluate the efficacy and safety of cetuximab combined with FOLFIRI in patients with advanced gastric cancer who failed first-line chemotherapy</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:40ce3944b498984f354888ac2f306b0e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:38648195dcabb6b27b398db39cfdcf4d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Phase II Study of Cetuximab (Erbitux&#174;) in Combination With Modified FOLFIRI in Patients With Advanced Gastric Cancer Who Failed to First-Line Chemotherapy</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:38648195dcabb6b27b398db39cfdcf4d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1b004c413d051ba6eb5d099d11562c95' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Up to now, although FU based, cisplatin based and taxane based regimen, and ECF regimen have been suggested as the first line therapy for A/MGC by FDA, there is no standard regimen for patients with A/MGC as second line treatment. Based on the promising results of cetuximab combined with FOLFIRI in metastatic colorectal cancer, we design this clinical trial to evaluate the efficacy and safety of cetuximab combined with FOLFIRI for A/MGC patients as a second line treatment.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:1b004c413d051ba6eb5d099d11562c95' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:182f4025c5db72c665d23d93cd12fc95' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Histologically confirmed advanced or metastatic adenocarcinoma of the stomach</li>\n<li>ECOG performance scale &#8804; 1</li>\n<li>At least one measurable lesion (larger than 10 mm in diameter by spiral CT scan)</li>\n<li>Adequate hepatic, renal, heart, and hematologic functions (platelets&#65310;80 &#215; 109/L, neutrophil&#65310;2.0 &#215; 109/L, serum creatinine &#8804; 1.5mg/dl, total bilirubin within upper limit of normal(ULN), and serum transaminase&#8804;2.5&#215;the ULN)</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Pregnant or lactating women</li>\n<li>Concurrent cancer</li>\n<li>History of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix</li>\n<li>Neuropathy, brain, or leptomeningeal involvement</li>\n<li>Uncontrolled significant comorbid conditions and previous radiotherapy</li>\n</ul>\n</p>', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:182f4025c5db72c665d23d93cd12fc95' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:7bf9ab0c1d528b7a3324a3619aaeed51' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Since it is not uncertain about efficacy of combination therapy with PSK and TS-1 in gastric cancer, in this study, we compare efficacy and safety of postoperative adjuvant therapy using TS-1 or TS-1+PSK in the stage II or III gastric cancer patients.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:7bf9ab0c1d528b7a3324a3619aaeed51' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5e59d623a7f99f515b3cd51b03f2bd98' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Phase III Randomized Controlled Study of Postoperative Adjuvant Therapy Using TS-1 or TS-1+PSK for Stage II or III Gastric Cancer Patients</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:5e59d623a7f99f515b3cd51b03f2bd98' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:78b706af0ac70b1d5ade649354c39503' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>TS-1 is an oral anticancer drug approved in Japan consisting of tegafur (a pro-drug of fluorouracil, 5-FU), gimeracil and oteracil potassium. The response rate of TS-1 in the untreated advanced gastric cancer patients was 44.6% in the late phase II study. In 2007, efficacy of the adjuvant therapy using TS-1 in the resected gastric cancer patients was demonstrated by ACTS-GC study group conducted in Japan. PSK is an oral anticancer drug approved in Japan consisting of protein-bound polysaccharide extracted from mycelium of Trametes (Coriolus) versicolor, a kind of mushroom. Even though survival benefit by PSK in combination with adjuvant chemotherapy using 5-FU or tegafur in the postoperative gastric cancer patients was already demonstrated, it is not uncertain about efficacy of combination therapy with PSK and TS-1 in gastric cancer. In this study, we compare efficacy and safety of postoperative adjuvant therapy using TS-1 or TS-1+PSK in the stage II or III gastric cancer patients.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:78b706af0ac70b1d5ade649354c39503' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:140702a8a33fb9c73831fc52c544c3d6' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Patient who is pathologically confirmed as gastric cancer</li>\n<li>Patient who has received surgery with D2 or more lymph node dissection and whose final curability of surgical resection is grade A or B</li>\n<li>Patient whose final stage is II (except for T1), IIIA, or IIIB</li>\n<li>Patient without liver, peritoneal and distant metastasis, and who is negative in peritoneal cytological diagnosis</li>\n<li>Patient whose age at the registration is ranging between 20 and 80 years old</li>\n<li>Patient who has not received any preoperative therapy including radiotherapy, chemotherapy and immunotherapy</li>\n<li>Patient who has received surgery for gastric cancer within six weeks before the registration, and is judged to be capable of oral administration</li>\n<li>Patient who has no serious concurrent complications, and satisfies the following criteria\n<ul>\n<li>White blood cell count: &gt; LLN or &gt; 4,000 /mm3</li>\n<li>Platelet count: &gt; 100,000 /mm3</li>\n<li>Serum total bilirubin: &lt; 1.5 mg/dL</li>\n<li>Serum AST (GOT), ALT (GPT): &lt; 2.5 * ULN</li>\n<li>Serum creatinine: &lt; ULN</li>\n</ul>\n</li>\n<li>Patient who has received an explanation of this study by assent documents, and has given written informed consent to participate in this study</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Patient with metachronous or synchronous multicancer</li>\n<li>Patient who contraindicates to TS-1</li>\n<li>Patient who requires continuous use of flucytosine, phenytoin or warfarin potassium</li>\n<li>Patient who has experienced serious drug allergy over grade 3 in the past</li>\n<li>Patient with serious complications including paralysis of intestine, ileus, interstitial pneumonitis, fibroid lung, uncontrollable diabetes mellitus, heart insufficiency, renal insufficiency or hepatic insufficiency</li>\n<li>Patient with diarrhea (watery stool)</li>\n<li>Patient who is pregnant or in lactation, or wish to become pregnant during this study</li>\n<li>Male patient who intends to make someone pregnant during this study</li>\n<li>Patient with HIV positive</li>\n<li>Patient who is judged to be inappropriate as subject to this study by the principal investigator or the doctors in charge</li>\n</ul>\n</p>', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:140702a8a33fb9c73831fc52c544c3d6' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:443e7075361cfc426b8cc723e12a6744' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Vandetanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. It is not yet known whether docetaxel is more effective when given together with or without vandetanib. PURPOSE: This randomized phase II trial is studying docetaxel to see how well it works compared with docetaxel given together with vandetanib in treating patients with metastatic stomach cancer or gastroesophageal junction cancer.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:443e7075361cfc426b8cc723e12a6744' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e760e13ccf51ba2a55bfe1ce9261f68a' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Toxicity [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:e760e13ccf51ba2a55bfe1ce9261f68a' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Overall survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0e79568ecdbbf006d075c1c708fed460' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Progression-free survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:0e79568ecdbbf006d075c1c708fed460' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:661fe6dc4346768aba1ccd4958ea4df5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to evaluate the safety and time to progression of HLA-A*2402 restricted epitope peptides URLC10, KOC1, VEGFR1 and VEGFR2 emulsified with Montanide ISA 51.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:661fe6dc4346768aba1ccd4958ea4df5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3364e425176215ed6b02ac4774dc7a43' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Phase I/II Study of Multiple-Vaccine Therapy Using Epitope Peptide Restricted to HLA-A*2402 in Treating Patients With Refractory Gastric Cancer</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:3364e425176215ed6b02ac4774dc7a43' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:74f81cf55a153d1b65d7fa61ade3a32d' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>URLC10 and KOC1 have been identified as cancer specific molecules especially in non small cell lung cancer using genome-wide expression profile analysis by cDNA microarray technique. In a prior study, it has been shown that URLC10 and KOC1 are upregulated in human gastric tumors. VEGF receptor 1 and 2 are essential targets to tumor angiogenesis, and we identified that peptides derived from these receptors significantly induce the effective tumor specific CTL response in vitro and vivo. According to these findings, in this trial, we evaluate the safety, immunological and clinical response of those peptides. Patients will be vaccinated twice a week for 8 weeks. On each vaccination day, the URLC10 peptide (1mg), KOC1 peptide (1mg), VEGFR1 peptide (1mg) and VEGFR2 peptide (1mg) mixed with Montanide ISA 51 will be administered by subcutaneous injection. The patients will also receive oral chemotherapy (S-1) simultaneously. Repeated cycles of vaccine will be administered until patients develop progressive disease or unacceptable toxicity, whichever occurs first. In the phase I study, we evaluate the safety and tolerability of these peptide vaccines. In the following phase II study, we evaluate the immunological and clinical response of this vaccine therapy.</p>\n', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:74f81cf55a153d1b65d7fa61ade3a32d' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:45dde058f72bcc1beed6298d863b6e14' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Advanced or recurrent gastric cancer</li>\n<li>Resistant against conventional chemotherapy or difficult to continue the chemotherapy due to intolerable side effect(s)</li>\n<li>ECOG performance status 0-2</li>\n<li>Life expectancy &gt; 3 months</li>\n<li>HLA-A*2402</li>\n<li>Laboratory values as follows 2000/mm3&lt;WBC&lt;15000/mm3 Platelet count&gt;100000/mm3 Bilirubin &lt; 3.0mg/dl Asparate transaminase &lt; 150IU/L Alanine transaminase &lt; 150IU/L Creatinine &lt; 3.0mg/dl</li>\n<li>Able to receive oral TS-1 therapy</li>\n<li>Able and willing to give valid written informed consent</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Pregnancy (woman of childbearing potential:Refusal or inability to use effective means of contraception)</li>\n<li>Breastfeeding</li>\n<li>Active or uncontrolled infection</li>\n<li>Unhealed external wound</li>\n<li>Concurrent treatment with steroids or immunosuppressing agent</li>\n<li>Prior chemotherapy, radiation therapy, and/or immunotherapy within 4 weeks</li>\n<li>Uncontrolled brain and/or intraspinal metastasis</li>\n<li>History of allergy to Tegaful, Gimeracil and/or Oteracil</li>\n<li>Decision of unsuitableness by principal investigator or physician-in-charge</li>\n</ul>\n</p>', created = 1283940110, expire = 1284026510, headers = '', serialized = 0 WHERE cid = '1:45dde058f72bcc1beed6298d863b6e14' in /persistent/html/includes/cache.inc on line 109.

Allogeneic Whole Cell Cancer Vaccine for Metastatic Epithelial Tumors

Trial phase: 
Phase I
Recruitment status: 
Not yet recruiting

This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with colorectal, gastric, ovarian, breast or lung epithelial cancer. Tumor cells grown in the laboratory will be modified to make them stimulatory to the immune system, irradiated to kill them, and injected to the patient eight times at two-week intervals . This protocol is expected to prolong survival of metastatic epithelial cancer patients.

Background information
Trial ID: 
NCT00722228
Other unique IDs: 
0359-08-HMO-CTIL
Official title: 

 

Detailed description: 

 

Number to be enrolled: 
0 patients

AMG 102 Plus ECX for Unresectable Locally Advanced or Metastatic Gastric or Esophagogastric Junction Cancer

Trial phase: 
Phase I
Recruitment status: 
Recruiting

Study Phase: 1b/2 Indication: Previously untreated subjects with unresectable locally advanced or metastatic gastric or esophagogastric junction adenocarcinoma. Primary Objective(s): Part 1: To identify safe dose levels of AMG 102, up to 15 mg/kg Q3W, to combine with ECX. Part 2 (phase 2-double-blind): To estimate with pre-specified precision the effect of the addition of AMG 102 to ECX on progression free survival (PFS).

Background information
Trial ID: 
NCT00719550
Other unique IDs: 
20060317
Official title: 

A Multicenter, Double-Blind, 3-Arm, Phase 1b/2 Study in Subjects With Unresectable Locally Advanced or Metastatic Gastric or Esophagogastric Junction Adenocarcinoma to Evaluate the Safety and Efficacy of First-Line Treatment With Epirubicin, Cisplatin, an

Detailed description: 

 

Number to be enrolled: 
136 patients

Postoperative Chemotherapy and Chemo-Radiotherapy for Resected Gastric Cancer

Trial phase: 
Phase II
Recruitment status: 
Recruiting

This study will determine the feasibility of adjuvant chemotherapy and chemo-radiotherapy for patients with surgically resected adenocarcinoma of the stomach and gastro-esophageal junction.

Background information
Trial ID: 
NCT00718913
Other unique IDs: 
CT/08.07
Official title: 

A Phase II Trial of Postoperative Chemotherapy and Chemo-Radiotherapy for Resected Adenocarcinoma of the Stomach and Gastro-Esophageal Junction

Detailed description: 

Patients with localized gastric cancer often relapse either locally or systemically. A strategy to reduce relapses at common sites would be beneficial. Our prior trial has proved the feasibility of administering FOLFIRI regimen as adjuvant chemotherapy combined with adjuvant chemoradiation in patients with excised with curative intend gastric cancer. It would be important to improve the treatment involving active regimen as adjuvant chemotherapy and optimizing chemoradiation by introducing capecitabine as a radiosensitizer.

Number to be enrolled: 
49 patients

Overall Survival of Inoperable Gastric/GastroOesophageal Cancer Subjects on Treating With LMWH + Chemotherapy(CT) Versus Standard CT

Due to evidence available both in terms of efficacy and safety of low molecular weight heparin, its use for the prevention of thromboembolic disease in cancer patients undergoing surgical intervention, and its extended use in higher doses for the prevention of recurrent thromboembolism in cancer patients with established thrombosis, with a view that the potential benefits for survival in cancer patients from low molecular weight heparin therapy comes because of a biological activity, the dose of 1mg/Kg (50% of the full treatment dose) for a period of 6 months coincident with 6 cycles of chemotherapy, has been chosen for this study.

Background information
Other unique IDs: 
TRI0702

Docetaxel, Oxaliplatin, and Fluorouracil in Treating Patients With Metastatic or Unresectable Stomach Cancer, Gastroesophageal Junction Cancer, or Other Solid Tumor

Trial phase: 
Phase I
Recruitment status: 
Recruiting

RATIONALE: Drugs used in chemotherapy, such as docetaxel, oxaliplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of docetaxel when given with oxaliplatin and fluorouracil and to see how well they work in treating patients with metastatic or unresectable stomach cancer, gastroesophageal junction cancer, or other solid tumor.

Background information
Trial ID: 
NCT00711243
Other unique IDs: 
CDR0000599734
NU-0412
SANOFI - AVENTIS-NU0412
NU-948-006
Official title: 

A Phase I/II Study of Taxotere, Oxaliplatin, and 5- Fluorouracil

Detailed description: 

OBJECTIVES: Primary

  • To establish the maximum tolerated dose of docetaxel when administered with oxaliplatin and fluorouracil in patients with metastatic or unresectable solid tumors. (Phase I)
  • To determine the response rate in patients with metastatic or unresectable adenocarcinoma of the stomach or gastroesophageal junction treated with this regimen. (Phase II)

Number to be enrolled: 
73 patients

Cognitive and Behavioral Therapy or Standard Care in Patients With Advanced Gastrointestinal Cancer or Lung Cancer

Recruitment status: 
Recruiting

RATIONALE: Providing cognitive and behavioral therapy may improve the well-being and quality of life of patients with advanced cancer. PURPOSE: This randomized clinical trial is studying cognitive and behavioral therapy to see how well it works compared with standard care in treating patients with advanced gastrointestinal cancer or lung cancer.

Background information
Trial ID: 
NCT00706290
Other unique IDs: 
CDR0000597438
MGH-2007-P-000368
Official title: 

Brief CBT for Anxiety and Advanced Cancer

Detailed description: 

OBJECTIVES:

  • To develop and examine the feasibility and patient acceptability of administering a manualized cognitive-behavioral intervention that improves quality of life by treating anxiety in patients with advanced gastrointestinal cancer or lung cancer.
  • To estimate the effect size of a manualized cognitive-behavioral intervention to reduce anxiety in patients with advanced lung or gastrointestinal cancer.
  • To estimate the effect size for the secondary outcomes (i.e., depression and quality of life) and to examine the extent to which specific variables (i.e., sex
Number to be enrolled: 
60 patients

Study of Cetuximab to Treat Gastric Cancer

Trial phase: 
Phase II
Recruitment status: 
Recruiting

The purpose of this study is to evaluate the efficacy and safety of cetuximab combined with FOLFIRI in patients with advanced gastric cancer who failed first-line chemotherapy

Background information
Trial ID: 
NCT00699881
Other unique IDs: 
EMR 62202- 806
Official title: 

Phase II Study of Cetuximab (Erbitux®) in Combination With Modified FOLFIRI in Patients With Advanced Gastric Cancer Who Failed to First-Line Chemotherapy

Detailed description: 

Up to now, although FU based, cisplatin based and taxane based regimen, and ECF regimen have been suggested as the first line therapy for A/MGC by FDA, there is no standard regimen for patients with A/MGC as second line treatment. Based on the promising results of cetuximab combined with FOLFIRI in metastatic colorectal cancer, we design this clinical trial to evaluate the efficacy and safety of cetuximab combined with FOLFIRI for A/MGC patients as a second line treatment.

Number to be enrolled: 
55 patients
Acronym: 
EFFI

Study of TS-1 or TS-1 + PSK for Gastric Cancer Patients

Trial phase: 
Phase III
Recruitment status: 
Recruiting

Since it is not uncertain about efficacy of combination therapy with PSK and TS-1 in gastric cancer, in this study, we compare efficacy and safety of postoperative adjuvant therapy using TS-1 or TS-1+PSK in the stage II or III gastric cancer patients.

Background information
Trial ID: 
NCT00687843
Other unique IDs: 
TMOG-GC01
Official title: 

Phase III Randomized Controlled Study of Postoperative Adjuvant Therapy Using TS-1 or TS-1+PSK for Stage II or III Gastric Cancer Patients

Detailed description: 

TS-1 is an oral anticancer drug approved in Japan consisting of tegafur (a pro-drug of fluorouracil, 5-FU), gimeracil and oteracil potassium. The response rate of TS-1 in the untreated advanced gastric cancer patients was 44.6% in the late phase II study. In 2007, efficacy of the adjuvant therapy using TS-1 in the resected gastric cancer patients was demonstrated by ACTS-GC study group conducted in Japan. PSK is an oral anticancer drug approved in Japan consisting of protein-bound polysaccharide extracted from mycelium of Trametes (Coriolus) versicolor, a kind of mushroom.

Number to be enrolled: 
480 patients
Acronym: 
TMOG-GC01

Docetaxel With or Without Vandetanib in Treating Patients With Metastatic Stomach Cancer or Gastroesophageal Junction Cancer

RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Vandetanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. It is not yet known whether docetaxel is more effective when given together with or without vandetanib. PURPOSE: This randomized phase II trial is studying docetaxel to see how well it works compared with docetaxel given together with vandetanib in treating patients with metastatic stomach cancer or gastroesophageal junction cancer.

Background information
Other unique IDs: 
CDR0000596150
RPCI-I-106207

Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in Patients With Gastric Cancer

Trial phase: 
Phase I
Recruitment status: 
Active, not recruiting

The purpose of this study is to evaluate the safety and time to progression of HLA-A*2402 restricted epitope peptides URLC10, KOC1, VEGFR1 and VEGFR2 emulsified with Montanide ISA 51.

Background information
Trial ID: 
NCT00681577
Other unique IDs: 
IMS-MKA2402
Official title: 

Phase I/II Study of Multiple-Vaccine Therapy Using Epitope Peptide Restricted to HLA-A*2402 in Treating Patients With Refractory Gastric Cancer

Detailed description: 

URLC10 and KOC1 have been identified as cancer specific molecules especially in non small cell lung cancer using genome-wide expression profile analysis by cDNA microarray technique. In a prior study, it has been shown that URLC10 and KOC1 are upregulated in human gastric tumors. VEGF receptor 1 and 2 are essential targets to tumor angiogenesis, and we identified that peptides derived from these receptors significantly induce the effective tumor specific CTL response in vitro and vivo.

Number to be enrolled: 
14 patients
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