Colorectal Cancer

user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:4f520676ec4d87f8ffd1603b45774e49' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Learning how often patients experience nausea and vomiting after receiving anti-vomiting medicine and chemotherapy for colorectal cancer may help doctors plan better treatment and improve patients\' quality of life. PURPOSE: This clinical trial is studying delayed nausea and vomiting in patients with colorectal cancer receiving standard anti-vomiting medicine during the first course of chemotherapy.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:4f520676ec4d87f8ffd1603b45774e49' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:536d6032ec6714c164933b3d8a2ec07a' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Prevalence of Delayed Nausea and Vomiting in Patients Being Treated With Oxaliplatin-Based Regimens (mFOLFOX6 or FOLFOX7) for Colorectal Cancer\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:536d6032ec6714c164933b3d8a2ec07a' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:dc621dc6b6899550697e95556a79a594' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES:\n<ul>\n<li>To assess the prevalence of delayed nausea and vomiting in patients with colorectal cancer receiving standard anti-emetic medications during the first course of an oxaliplatin-based chemotherapy regimen (mFOLFOX6 or FOLFOX7).</li>\n</ul>\n OUTLINE: This is a multicenter study. Patients undergo collection of demographic, diagnostic, and treatment data at baseline. Patients complete the Functional Living Index-Emesis (FLIE) questionnaire at baseline prior to first chemotherapy infusion and at 5-7 days. Patients also fill out daily patient diaries about symptoms of nausea and vomiting, and use of medications to prevent these symptoms over days 1-5.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:dc621dc6b6899550697e95556a79a594' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ad8d6542b8b6871105ea636fc50c4af1' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Diagnosis of colorectal cancer</li>\n<li>Currently receiving OR scheduled to receive the first course of either of the following chemotherapy regimens:\n<ul>\n<li>mFOLFOX6</li>\n<li>FOLFOX7</li>\n</ul>\n</li>\n<li>No clinical or imaging evidence of brain metastasis</li>\n</ul>\n PATIENT CHARACTERISTICS:\n<ul>\n<li>Able to maintain a diary and complete a standardized quality of life questionnaire in English</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>More than 90 days since prior aprepitant</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:ad8d6542b8b6871105ea636fc50c4af1' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:615361d89c6fa9031188068fcb36a664' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Presence and degree of nausea and vomiting in the acute and delayed phases after oxaliplatin-based chemotherapy as recorded in the patient\'s diary over days 1-5 [ Designated as safety issue: Yes ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:615361d89c6fa9031188068fcb36a664' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c7e9b1a56f8c295866e6de2b47331b8d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Impact of nausea and vomiting on the patient\'s quality of life as measured by the Functional Living Index - Emesis scale at baseline and at 5-7 days [ Designated as safety issue: Yes ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:c7e9b1a56f8c295866e6de2b47331b8d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c277ea3761385a99f573ec23f0311b63' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Comparison of this study\'s findings with those from aprepitant-containing anti-emetic studies conducted with cisplatin-containing regimens [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:c277ea3761385a99f573ec23f0311b63' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:12ac235c24e674090a4b1e9a42155976' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Investigation of potential factors predisposing patients to nausea and vomiting (e.g., gender, age, prior chemotherapy experience, or tendency toward development of motion-sickness) [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:12ac235c24e674090a4b1e9a42155976' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:258a2cbdc6af352c8ed256b6cf376514' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Laparoscopic-assisted resection is a less invasive type of surgery for rectal cancer and may have fewer side effects and improve recovery. It is not yet known whether laparoscopic-assisted resection is more effective than open resection in treating patients with rectal cancer. PURPOSE: This randomized phase III trial is studying laparoscopic-assisted resection to see how well it works compared with open resection in treating patients with stage IIA, stage IIIA, or stage IIIB rectal cancer.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:258a2cbdc6af352c8ed256b6cf376514' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5acdd40f9da7644f8cce6b84dbbd488f' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'A Phase III Prospective Randomized Trial Comparing Laparoscopic-Assisted Resection Versus Open Resection for Rectal Cancer\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:5acdd40f9da7644f8cce6b84dbbd488f' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c6c310242d5a49885bb4d08f54d69bce' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES: Primary\n<ul>\n<li>To test the hypothesis that laparoscopic-assisted resection is not inferior to open resection, based on a composite primary endpoint of oncologic factors that are indicative of a safe and feasible surgical resection, in patients with stage IIA, IIIA, or IIIB rectal cancer.</li>\n</ul>\n Secondary\n<ul>\n<li>To compare the patient-related benefit of laparoscopic-assisted resection vs open resection, in terms of blood loss, length of stay, and utilization of pain medication.</li>\n<li>To compare the disease-free survival and local pelvic recurrence at 2 years.</li>\n<li>To compare the quality of life, sexual function, and bowel and stoma function.</li>\n</ul>\n OUTLINE: This is a multicenter study. Patients are stratified according to site of primary tumor (high vs middle vs low rectum), registering surgeon, and planned operative procedure (low anterior resection vs abdominal perineal resection). Patients are randomized to 1 of 2 treatment arms.\n<ul>\n<li>Arm I: Patients undergo open laparotomy and rectal resection.</li>\n<li>Arm II: Patients undergo laparoscopic-assisted rectal resection. Quality of life is assessed periodically using EORTC Quality of Life Questionnaires (EORTC QLQ-C30 and -CR38), the Linear Analog Self-Assessment (LASA), the Stoma Quality of Life Scale (SQOLS), and the Mayo Bowel Function Questionnaire (MBFQ).</li>\n</ul>\n After completion of study treatment, patients are followed periodically for up to 5 years.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:c6c310242d5a49885bb4d08f54d69bce' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ba28ba2f8a8d2cedc6d86b182aae3aa5' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed adenocarcinoma of the rectum (≤ 12 cm from the anal verge)\n<ul>\n<li>T3, N0, M0 or any T, N1-2, M0 disease by CT scan and pelvic MRI or transrectal ultrasound\n<ul>\n<li>No T4 disease extending to the circumferential margin of rectum or invading adjacent organs</li>\n</ul>\n</li>\n</ul>\n</li>\n<li>Must have completed neoadjuvant fluorouracil-based chemotherapy and/or radiotherapy within the past 4 weeks\n<ul>\n<li>Capecitabine may have been substituted for fluorouracil</li>\n</ul>\n</li>\n</ul>\n PATIENT CHARACTERISTICS:\n<ul>\n<li>ECOG performance status 0-2</li>\n<li>Body mass index ≤ 34</li>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test</li>\n<li>No evidence of conditions (e.g., multiple prior major laparotomies or severe adhesions) that would preclude use of a laparoscopic approach</li>\n<li>No systemic disease (e.g., cardiovascular, renal, or hepatic) that would preclude surgery</li>\n<li>No other severe incapacitating disease (i.e., ASA IV [severe systemic disease that is a constant threat to life] or ASA V [moribund and is not expected to survive without the operation])</li>\n<li>No other invasive pelvic malignancy (cervical, uterine, or rectal) within the past 5 years</li>\n<li>No history of psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:ba28ba2f8a8d2cedc6d86b182aae3aa5' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Overall survival [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fda837c2e4537dcece1f29e3be5f39c3' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Quality of life [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:fda837c2e4537dcece1f29e3be5f39c3' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:955254cde948984eb9e60ebac1471e8a' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Disease-free survival [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:955254cde948984eb9e60ebac1471e8a' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6ab5f22633b20666de88cdcb27bf26b2' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Circumferential margin > 1 mm [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:6ab5f22633b20666de88cdcb27bf26b2' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2e9da24ff100a403cb44e179d70412cf' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Distal resected margin > 2 cm (or > 1 cm with clear frozen section in the low rectum) [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:2e9da24ff100a403cb44e179d70412cf' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:98687a143eabfefaa6ae75b157e6ec80' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Completeness of total mesorectal excision [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:98687a143eabfefaa6ae75b157e6ec80' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f83c655f9cbd3d745803fc7d3fa2c6a3' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Patient-related benefit [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:f83c655f9cbd3d745803fc7d3fa2c6a3' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8cc5493c52239e7c0686c48dfc960dea' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Local pelvic recurrence rates [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:8cc5493c52239e7c0686c48dfc960dea' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:302434dedfd8c3215f39cba6d31934c9' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Sexual function and bowel function [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:302434dedfd8c3215f39cba6d31934c9' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5345c4b5ee91542f733de87975c8b24c' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'This study is a randomized multi-center trial that will assess the effect of adding SIRT, using SIR-Spheres microspheres, to a standard chemotherapy regimen of FOLFOX as first line therapy in patients with non-resectable liver metastases from primary colorectal adenocarcinoma.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:5345c4b5ee91542f733de87975c8b24c' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2a4b13859bf0e9063bb38d4de3ef4000' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Randomised Comparative Study Of Folfox6m Plus Sir-Spheres® Microspheres Versus Folfox6m Alone As First Line Treatment In Patients With Nonresectable Liver Metastases From Primary Colorectal Carcinoma\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:2a4b13859bf0e9063bb38d4de3ef4000' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = ' \n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:573022adc28a5b7d84d49ca2bec433a4' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Inclusion Criteria:\n<ul>\n<li>Histologically confirmed adenocarcinoma of the colon or rectum OR radiological evidence of carcinoma of the colon or rectum.</li>\n<li>Measurable evidence of non-resectable liver metastases</li>\n<li>Adequate haematological, renal and hepatic function</li>\n</ul>\n Exclusion Criteria:\n<ul>\n<li>Evidence of ascites, cirrhosis, portal hypertension, main portal venous tumour involvement or thrombosis</li>\n<li>Any extra-hepatic metastases</li>\n<li>Prior chemotherapy for metastatic colorectal cancer</li>\n<li>Pregnant or breast feeding</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:573022adc28a5b7d84d49ca2bec433a4' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5650289547ee540364ac5715ce9953b8' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with colorectal, gastric, ovarian, breast or lung epithelial cancer. Tumor cells grown in the laboratory will be modified to make them stimulatory to the immune system, irradiated to kill them, and injected to the patient eight times at two-week intervals . This protocol is expected to prolong survival of metastatic epithelial cancer patients.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:5650289547ee540364ac5715ce9953b8' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = ' \n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = ' \n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:52d0208a94ed93feaea61fa51f692e38' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Inclusion Criteria:\n<ul>\n<li>Metastatic epithelial cancer</li>\n<li>Above 18 years of age</li>\n<li>Failure of at least one chemotherapy protocol</li>\n<li>Clinical performance status of ECOG 0,1</li>\n<li>Absolute neutrophil count greater than 1000/mm3</li>\n<li>Serum ALT/AST less than three times the upper limit of normal</li>\n<li>Serum creatinine less than or equal to 1.6 mg/dl.</li>\n<li>Must be able to understand and sign the Informed Consent document</li>\n</ul>\n Exclusion Criteria:\n<ul>\n<li>Below 18 years of age</li>\n<li>Women who are pregnant</li>\n<li>Life expectancy of less than three months</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:52d0208a94ed93feaea61fa51f692e38' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5e06f02de8c0ebb2787ffec232f83d4d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'This is a randomized, multicenter study designed to evaluate the progression free survival of the SOL group (S-1, Leucovorin, and Oxaliplatin) compared with the mFOLFOX6 group (5-FU, l-LV and Oxaliplatin) as first-line treatment of patients with metastatic colorectal cancer.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:5e06f02de8c0ebb2787ffec232f83d4d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6447bfcf13b12522ab7dab02a8e61073' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Randomized Phase II Study of S-1, Oral Leucovorin, and Oxaliplatin Combination Therapy (SOL) Versus 5-FU, l-LV and Oxaliplatin Combination Therapy (mFOLFOX6) in Patients With Untreated Metastatic Colorectal Cancer\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:6447bfcf13b12522ab7dab02a8e61073' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = ' \n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f3d8db2f443a0047c3caa98282deb28b' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Inclusion Criteria:\n<ul>\n<li>Histologically proved adenocarcinoma (colorectal cancer).</li>\n<li>Age: 20 ≤ at enrollment.</li>\n<li>No prior treatment (ex. radiation therapy, chemotherapy, hormonal therapy) to advanced disease. Patients who received adjuvant chemotherapy more than 180 days before enrollment can be allowed but those who received S-1 or Oxaliplatin containing treatment shall be excluded.</li>\n<li>At least one measurable lesion by RECIST criteria</li>\n</ul>\n Exclusion Criteria:\n<ul>\n<li>Serious drug hypersensitivity.</li>\n<li>Prior history of peripheral neuropathy.</li>\n<li>Diarrhea .</li>\n<li>Simultaneously active double cancer.</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:f3d8db2f443a0047c3caa98282deb28b' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:8eac3ce5276bfb96318ce9889240693d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Drugs used in chemotherapy, such as irinotecan, oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether combination chemotherapy is more effective with or without bevacizumab in treating metastatic colorectal cancer. PURPOSE: This randomized phase III trial is studying second-line combination chemotherapy to see how well it works compared with or without bevacizumab in treating patients with metastatic colorectal cancer who have received first-line chemotherapy and bevacizumab.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:8eac3ce5276bfb96318ce9889240693d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:c7b2e9c50a773a6c3002db27ddb35eb0' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE III STUDY OF SECOND-LINE CHEMOTHERAPY WITH OR WITHOUT BEVACIZUMAB IN METASTATIC COLORECTAL CANCER PATIENTS WHO HAVE RECEIVED FIRST-LINE CHEMOTHERAPY PLUS BEVACIZUMAB.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:c7b2e9c50a773a6c3002db27ddb35eb0' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:eb780d8272b7a89f9127cf55b329ba97' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES: Primary\n<ul>\n<li>To compare the progression-free survival of second-line chemotherapy with or without bevacizumab in patients with metastatic colorectal cancer who have received first-line chemotherapy with bevacizumab.</li>\n</ul>\n Secondary\n<ul>\n<li>To compare the overall survival, response rate, and safety profile of second-line chemotherapy of these regimens in these patients.</li>\n<li>To conduct pharmacogenomics assessment of candidate variants in the VEGF gene and evaluate their association with progression-free survival and other study outcomes.</li>\n</ul>\n OUTLINE: This is a multicenter study. Patients are stratified according to participating center, ECOG performance status (0 vs 1-2), disease-free interval from the last administration of first-line chemotherapy for metastatic disease (≤ 3 months vs > 3 months), and type of second-line chemotherapy (irinotecan hydrochloride, leucovorin calcium, and fluorouracil [FOLFIRI] vs oxaliplatin, leucovorin calcium, and fluorouracil [mFOLFOX-6]). Patients are randomized to 1 of 2 treatment arms.\n<ul>\n<li>Arm I: Patients receive either irinotecan hydrochloride over 1 hour or oxaliplatin over 1 hour on day 1. Patients also receive leucovorin calcium IV over 2 hours and fluorouracil IV over 46 hours continuously beginning on day 1.</li>\n<li>Arm II: Patients receive combination chemotherapy as in arm I and bevacizumab IV on day 1.</li>\n</ul>\n Treatment in both arms repeats every 2 weeks for up to 12 courses in the absence of disease progression or unacceptable toxicity. Existing formalin-fixed paraffin-embedded tumor tissue samples are assessed for pharmacogenomics and markers predictive of response, resistance to, or toxicity from bevacizumab. Samples are analyzed via RT-PCR, array comparative genomic hybridization, fluorescence in situ hybridization, sequencing of candidate genes, and immunohistochemistry. After completion of study treatment, patients are followed for 1 year.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:eb780d8272b7a89f9127cf55b329ba97' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:61a1fdbf49d303595e38b388c13c3e6b' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed colorectal adenocarcinoma\n<ul>\n<li>Metastatic or unresectable disease</li>\n</ul>\n</li>\n<li>Progressive disease based on the following criteria:\n<ul>\n<li>Progression during or after first-line chemotherapy for metastatic disease, including any of the following:\n<ul>\n<li>Fluoropyrimidine-based monotherapy with bevacizumab</li>\n<li>Fluoropyrimidine and irinotecan hydrochloride-based doublet with bevacizumab</li>\n<li>Fluoropyrimidine and oxaliplatin-based doublet with bevacizumab</li>\n</ul>\n</li>\n<li>Progression after more than 3 months from the last administration of first-line chemotherapy for metastatic disease with a fluoropyrimidine, irinotecan hydrochloride, and oxaliplatin triplet (FOLFOXIRI) with bevacizumab to which the patient had previously responded</li>\n</ul>\n</li>\n<li>Measurable disease, as assessed by RECIST criteria</li>\n<li>No prior or concurrent CNS metastasis</li>\n</ul>\n PATIENT CHARACTERISTICS:\n<ul>\n<li>ECOG performance status 0-2</li>\n<li>Life expectancy > 3 months</li>\n<li>ANC ≥ 1,500/mm^3</li>\n<li>Platelet count ≥ 100,000/mm^3</li>\n<li>Hemoglobin ≥ 9 g/dL</li>\n<li>INR ≤ 1.5 times upper limit of normal (ULN)</li>\n<li>aPTT ≤ 1.5 ULN</li>\n<li>Serum bilirubin ≤ 1.5 times ULN</li>\n<li>AST and ALT ≤ 2.5 times ULN (< 5 times ULN if liver metastases present)</li>\n<li>Alkaline phosphatase ≤ 2.5 times ULN (< 5 times ULN if liver metastases present)</li>\n<li>Serum creatinine ≤ 1.5 times ULN</li>\n<li>Proteinuria < 2+ OR protein ≤ 1g by 24-hour urine</li>\n<li>Not pregnant or nursing</li>\n<li>Fertile patients must use effective contraception</li>\n<li>No bowel obstruction or subobstruction</li>\n<li>No history of inflammatory enteropathy</li>\n<li>No prior extensive intestinal resection (i.e., > hemicolectomy or extensive small intestine resection with chronic diarrhea)</li>\n<li>No symptomatic peripheral neuropathy > grade 2</li>\n<li>No active uncontrolled infection</li>\n<li>No active disseminated intravascular coagulation</li>\n<li>No prior or concurrent malignancy, except for curatively treated basal cell and squamous cell carcinoma of the skin, or in situ carcinoma of the cervix</li>\n<li>No clinically significant cardiovascular disease, including any of the following:\n<ul>\n<li>Cerebrovascular accident within the past 6 months</li>\n<li>Myocardial infarction within the past 6 months</li>\n<li>Unstable angina</li>\n<li>NYHA class II-IV chronic heart failure</li>\n<li>Uncontrolled arrhythmia</li>\n</ul>\n</li>\n<li>No uncontrolled hypertension</li>\n<li>No thromboembolic or hemorrhagic events within the past 6 months</li>\n<li>No evidence of bleeding diathesis or coagulopathy</li>\n<li>No serious, non healing wound/ulcer or serious bone fracture</li>\n<li>No significant traumatic injury within the past 28 days</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>At least 6 weeks since prior radiotherapy</li>\n<li>At least 4 weeks since prior surgery</li>\n<li>No prior first-line chemotherapy for metastatic disease without bevacizumab</li>\n<li>No prior cetuximab or other investigational agents</li>\n<li>More than 28 days since prior open biopsy</li>\n<li>More than 28 days since prior and no concurrent major surgical procedure</li>\n<li>No concurrent therapeutic anticoagulation, antiplatelet agents, or NSAID with anti-platelet activity\n<ul>\n<li>Acetylsalicylic acid ≤ 325 mg/day allowed</li>\n</ul>\n</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:61a1fdbf49d303595e38b388c13c3e6b' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cdb346abfbb13f4616a27fe69d0ba554' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Safety [ Designated as safety issue: Yes ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:cdb346abfbb13f4616a27fe69d0ba554' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Overall survival [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:496969d7db91b883af7a8c22a7dad757' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Response rate [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:496969d7db91b883af7a8c22a7dad757' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9ca5c591d2b4ac4d1c03df153eb1c1d2' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'RATIONALE: Drugs used in chemotherapy, such as irinotecan, oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving combination chemotherapy together with bevacizumab may kill more tumor cells. PURPOSE: This randomized phase III trial is comparing two combination chemotherapy regimens given together with bevacizumab to see how well they work as first-line therapy in treating patients with metastatic colorectal cancer that cannot be removed by surgery.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:9ca5c591d2b4ac4d1c03df153eb1c1d2' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d7bb1724d074228a94ebfa7bd996baea' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'A Phase III Randomized Trial of FOLFOXIRI + Bevacizumab Versus FOLFIRI + Bevacizumab as First- Line Treatment for Metastatic Colorectal Cancer.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:d7bb1724d074228a94ebfa7bd996baea' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ed3eb4df7dcb06ca6ea6c18d6d1e33d1' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'OBJECTIVES: Primary\n<ul>\n<li>To compare the progression-free survival of bevacizumab in combination with oxaliplatin, irinotecan hydrochloride, fluorouracil, and leucovorin calcium (FOLFOXIRI) versus bevacizumab in combination with irinotecan hydrochloride, fluorouracil, and leucovorin calcium (FOLFIRI) in patients with unresectable, metastatic colorectal cancer.</li>\n</ul>\n Secondary\n<ul>\n<li>To evaluate the safety profile, including long-term adverse events of these regimens in these patients.</li>\n<li>To compare the overall response rate, duration of response, and secondary R0 surgery rates of metastases and overall survival between treatment arms.</li>\n<li>To evaluate potential surrogate markers predictive of bevacizumab activity.</li>\n</ul>\n OUTLINE: This is a multicenter study. Patients are stratified according to ECOG performance status (0 vs 1-2), prior adjuvant chemotherapy (yes vs no), and participating center. Patients are randomized to 1 of 2 treatment arms.\n<ul>\n<li>Arm I (FOLFOXIRI): Patients receive irinotecan hydrochloride IV over 1 hour, oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours, and bevacizumab IV on day 1. Patients also receive fluorouracil IV continuously over 48 hours beginning on day 1.</li>\n<li>Arm II (FOLFIRI): Patients receive irinotecan hydrochloride IV over 1 hour, leucovorin calcium IV over 2 hours, and bevacizumab IV on day 1. Patients also receive fluorouracil IV continuously over 48 hours beginning on day 1. In both arms, treatment repeats every 2 weeks for up to 12 courses. Treatment with bevacizumab, fluorouracil, and leucovorin calcium continues in the absence of disease progression or unacceptable toxicity.</li>\n</ul>\n Patients undergo serum extraction and blood sample collection periodically for genotyping studies. Patients also undergo collection of tumoral sections from paraffin embedded primary and/or metastatic lesions periodically for immunohistochemical analyses. After completion of study treatment, patients are followed every 8 weeks.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:ed3eb4df7dcb06ca6ea6c18d6d1e33d1' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3703b3c5c122d7b902c26e629c1b14af' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed colorectal cancer\n<ul>\n<li>Unresectable metastatic disease</li>\n</ul>\n</li>\n<li>Measurable disease, defined as ≥ 1 measurable lesion according to RECIST criteria</li>\n<li>No prior chemotherapy for metastatic disease</li>\n<li>No untreated brain metastases, spinal cord compression, or primary brain tumors</li>\n<li>No history or evidence of CNS disease by physical examination unless adequately treated (e.g., uncontrolled seizure despite standard medical therapy or history of stroke)</li>\n</ul>\n PATIENT CHARACTERISTICS: Inclusion criteria:\n<ul>\n<li>ECOG performance status (PS) 0-2 (≤ 70 years of age) OR ECOG PS 0 (71-75 years of age)</li>\n<li>Life expectancy ≥ 12 weeks</li>\n<li>Neutrophils ≥ 1.5 x 10^9/L</li>\n<li>Platelet count ≥ 100 x 10^9/L</li>\n<li>Hemoglobin > 9 g/dL</li>\n<li>Total bilirubin ≤ 1.5 times upper limit of normal (ULN)</li>\n<li>AST and ALT ≤ 2.5 times ULN (≤ 5 times ULN if f liver metastases present)</li>\n<li>Alkaline phosphatase ≤ 2.5 times ULN (≤ 5 times ULN if liver metastases present)</li>\n<li>Creatinine clearance > 50 mL/min OR serum creatinine ≤ 1.5 times ULN</li>\n<li>Proteinuria < 2+ by dipstick OR urine protein ≤ 1 g by 24-hr urine collection</li>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test</li>\n<li>Fertile patients must use effective contraception</li>\n</ul>\n Exclusion criteria:\n<ul>\n<li>Serious, nonhealing wound, ulcer, or bone fracture</li>\n<li>Evidence of bleeding diathesis or coagulopathy</li>\n<li>Uncontrolled hypertension</li>\n<li>Clinically significant (i.e., active) cardiovascular disease, including any of the following:\n<ul>\n<li>Cerebrovascular accidents within the past 6 months</li>\n<li>Myocardial infarction within the past 6 months</li>\n<li>Unstable angina</li>\n<li>New York Heart Association class II-IV congestive heart failure</li>\n<li>Serious cardiac arrhythmia requiring medication</li>\n</ul>\n</li>\n<li>Known allergy to Chinese hamster ovary cell proteins or any of the components of the study medications</li>\n<li>Other co-existing malignancy or malignancy diagnosed within the past 5 years, except for basal cell or squamous cell carcinoma, or carcinoma in situ of the cervix</li>\n<li>Symptomatic peripheral neuropathy ≥ grade 1 according to the NCI Common Toxicity Criteria</li>\n<li>Lack of physical integrity of the upper gastrointestinal tract</li>\n<li>Malabsorption syndrome</li>\n<li>Inability to take oral medication</li>\n<li>Significant traumatic injury within the past 28 days</li>\n</ul>\n PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>More than 4 weeks since prior radiotherapy</li>\n<li>More than 10 days since prior and no concurrent ongoing treatment with anticoagulants for therapeutic purposes</li>\n<li>More than 28 days since prior and no concurrent major surgical procedure</li>\n<li>More than 28 days since prior open biopsy</li>\n<li>More than 30 days since prior investigational agents</li>\n<li>No concurrent chronic daily high-dose acetylsalicylic acid (> 325 mg/day)</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:3703b3c5c122d7b902c26e629c1b14af' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Overall survival [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ee28679e59cceacccdd3b0ead00a1752' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Duration of response [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:ee28679e59cceacccdd3b0ead00a1752' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0c662c9aa299a69083abe115daccf333' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Overall response rate [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:0c662c9aa299a69083abe115daccf333' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:937715371a6a78222a5f5dcd7ed753eb' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Secondary R0 surgery rates of metastases [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:937715371a6a78222a5f5dcd7ed753eb' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:5e5c4ca69aa158998ebf14e6f3ab98b3' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Surrogate markers predictive of bevacizumab activity [ Designated as safety issue: No ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:5e5c4ca69aa158998ebf14e6f3ab98b3' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:fd95bb5b68483d824eb0748eb23762da' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Open-label phase 1b trial. Study treatment will be administered in 3 week cycles. There are two distinct parts in this study:\n<ul>\n<li>Part 1: Dose escalation from IMO-2055</li>\n<li>Part 2: Once a recommended phase 2 dose is found additional tolerability and pharmacodynamics will be explored</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:fd95bb5b68483d824eb0748eb23762da' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1d336dbfff949d291fa1a35d18610b06' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Open-Label Phase 1b Study of Irinotecan Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer Who Have Progressed Following Chemotherapy for Advanced or Metastatic Disease\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:1d336dbfff949d291fa1a35d18610b06' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:610451e60d80c249d697e120a4d4243e' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<ul>\n<li>Part 1: Dose escalation of IMO-2055, including 4 dose groups. Once a recommended phase 2 dosage (RP2D) of IMO-2055 given concomitantly with irinotecan and cetuximab is found the selected cohort will be expanded by an additional 6 to 9 patients (to a total of 12 patients) for confirmation of the RP2D and combination treatment regimen.</li>\n<li>Part 2: A final cohort of 12 patients (Cohort 6) will be enrolled simultaneously to explore tolerability and pharmacodynamics in patients treated with the RP2D of IMO-2055 in combination with irinotecan with cetuximab.</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:610451e60d80c249d697e120a4d4243e' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3b5fb4dffc7b03dbc00bf21a2cdf7208' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Inclusion Criteria:\n<ul>\n<li>Histologically confirmed adenocarcinoma of the colon or rectum with metastatic disease.</li>\n<li>Patients whose disease has recurred or progressed during or within 6 months of completion of standard therapy or patients stopping standard therapy due to excessive toxicity within the first 8 weeks.</li>\n<li>One additional prior regimen is permitted for neoadjuvant, adjuvant, or neoadjuvant plus adjuvant therapy.</li>\n</ul>\n Exclusion Criteria:\n<ul>\n<li>Administration of any chemotherapy, biotherapy, radiotherapy, investigational agent or major surgery, within 4 weeks prior to first study dosing.</li>\n<li>Inadequate bone marrow, liver, and renal function</li>\n<li>Other significant medical diseases</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:3b5fb4dffc7b03dbc00bf21a2cdf7208' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:3ed6e3d5fb917f3e653bb8cda822ef97' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'To evaluate the safety of weekly IMO-2055 combined with irinotecan plus cetuximab. [ Time Frame: throughout Study ] [ Designated as safety issue: Yes ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:3ed6e3d5fb917f3e653bb8cda822ef97' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a756f2b88ca28849387c67f5d616e34a' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'To investigate the pharmacokinetics (PK) of IMO-2055, cetuximab, and irinotecan. [ Time Frame: throughout study ] [ Designated as safety issue: Yes ]\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:a756f2b88ca28849387c67f5d616e34a' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:2bea6b8064765bcb29fe6aef8c90d60d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'This is a study to determine how much nausea and or vomiting is caused by irinotecan-based chemotherapy in patients with colorectal cancer. Patients with colorectal cancer scheduled to receive their first cycle of an irinotecan-based chemotherapy regimen are eligible. Any chemotherapy agents administered in combination with irinotecan must have low-minimal potential to cause nausea and or vomiting. Examples of acceptable regimens would be irinotecan in combination with infusional fluorouracil and leucovorin (FOLFRI) with or without bevacizumab and irinotecan in combination with cetuximab. Patients who have received prior non-irinotecan-based chemotherapy are eligible providing they experienced no vomiting and no greater than mild nausea with their prior chemotherapy.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:2bea6b8064765bcb29fe6aef8c90d60d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ee728d496106027c84624bc62dcacd7c' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Prospective Evaluation of the Incidence of Nausea and Vomiting in Patients With Colorectal Cancer Receiving Irinotecan-Based Therapy\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:ee728d496106027c84624bc62dcacd7c' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f3adbd6f642711cdc60da403179199f2' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Irinotecan is a camptothecin analog which exerts its cytotoxic effects by forming a covalent complex with topoisomerase I and DNA, resulting in inhibition of DNA re-ligation, accumulation of DNA double strand breaks and apoptotic cell death (1). Irinotecan is FDA approved for use in the front-line and second-line treatment of colorectal cancer. It has also demonstrated activity in a variety of other non-hematologic tumors. The recently updated ASCO antiemetic guidelines characterize irinotecan as having moderate emetic risk. (2). However, the emetogenic potential of this agent has been poorly characterized and there are no published prospective trials with emesis as a primary-end point. In addition there is a complete paucity of information on the potential of irinotecan to induce emesis beyond the first day after chemotherapy, so-called delayed emesis. Best characterized following cisplatin, delayed emesis is also associated with a number of other chemotherapy agents that similar to irinotecan appear to be moderately emetogenic such as carboplatin, cyclophosphamide and doxorubicin. Antiemetic prophylaxis for delayed emesis following irinotecan is not routinely prescribed at the present time. Prospectively obtained information on the potential of irinotecan to cause delayed emesis would be helpful in guiding appropriate antiemetic practice.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:f3adbd6f642711cdc60da403179199f2' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1ccf8ec9f3ce16b205b40356eb3a7faf' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Inclusion Criteria:\n<ul>\n<li>Patients with colorectal cancer receiving irinotecan in combination with infusional fluorouracil and leucovorin (FOLFRI) with or without bevacizumab or irinotecan in combination with cetuximab</li>\n<li>All patients will receive the following standard antiemetic regimen prior to chemotherapy:</li>\n<li>Dexamethasone 8 mg PO/IV</li>\n<li>An approved dose of a 5HT3 receptor antagonist. Ondansetron 8mg IV or 24mg PO Dolasetron 100mg IV/PO Granisetron 1 mg IV or 2mg PO Use of palonosetron will be excluded on this trial No routine prophylaxis for delayed emesis will be given. Patients will be instructed in the use of rescue antiemetics if needed.</li>\n<li>Minimum age of 18 years.</li>\n<li>Premenopausal patients must demonstrate a negative serum or urine pregnancy test prior to receiving chemotherapy.</li>\n<li>ECOG performance status of 0-2 (Appendix A)</li>\n<li>Execution of written informed consent</li>\n</ul>\n Exclusion Criteria:\n<ul>\n<li>Patients with history of moderate-severe nausea or any vomiting with prior chemotherapy including irinotecan based chemotherapy.</li>\n<li>Concomitant use of any drug with potential antiemetic efficacy (Appendix B) 24 hours before chemotherapy and during the 120 hour study period.</li>\n</ul>\n Chronic use (more than 2 weeks) of benzodiazepines is allowed.\n<ul>\n<li>Vomiting, retching or nausea (NCI > 1) in the 24 hours preceding chemotherapy</li>\n<li>Palliative surgery < 2 weeks from study entry</li>\n<li>Concurrent radiotherapy</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:1ccf8ec9f3ce16b205b40356eb3a7faf' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cd5938aaa9828ad7824976a73ac04922' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'The purpose of this study is to determine if the degree of agreement between patients and their physicians regarding the "story" of the illness correlates with improved patient symptom control and quality of life. Another goal of the study is to examine the actual language used by patients and physicians in a specific clinical situation.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:cd5938aaa9828ad7824976a73ac04922' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:55383d04c9a7dfea8c9e1262831d102d' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Critical Negotiations: Narrative Agreement, Negotiation, and Register Use in Encounters Between Patients With Metastatic Colorectal Carcinoma and Their Oncologists\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:55383d04c9a7dfea8c9e1262831d102d' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:10c7c63edf7f728e1b1a05844adbfabb' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'The purpose of this study is to investigate the co-created therapeutic narrative in scheduled office visits between adult patients with metastatic colorectal carcinoma and their medical oncologists in a community practice setting. The study will focus on the negotiation of the illness narrative and the semiotic (primarily linguistic) tools employed. The study will involve patients from a large community cancer center from Northeastern Pennsylvania (this center sees about 3,000 new patients each year). About 85% of patients with cancer in the United States are treated in this type of setting (National Cancer Institute, 2007), and so many results from this population are applicable to most cancer patients in the United States. The location of this study makes it very different from the majority of medical anthropological studies that are usually performed in urban academic medical centers or in sites outside of the United States or Western Europe. Although community cancer centers are the location of most of the treatment of patients with cancer in the United States, there are few to no studies published studying this patient population.\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:10c7c63edf7f728e1b1a05844adbfabb' in /persistent/html/includes/cache.inc on line 109.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:67e4713599de84d2acd30c14dcd23425' in /persistent/html/includes/cache.inc on line 26.
user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = 'Inclusion Criteria:\n<ul>\n<li>Patients and Physicians at Hematology and Oncology Associates of NE Pennsylvania</li>\n<li>Patients must have metastatic (stage IV) colorectal carcinoma</li>\n<li>Patients must be on treatment for their disease</li>\n<li>Patients must be scheduled for re-staging CT scans</li>\n<li>Patients must be older than 18 years old</li>\n</ul>\n Exclusion Criteria:\n<ul>\n<li>Patients with a diagnosis other than metastatic colorectal carcinoma</li>\n<li>Patients not receiving active treatment or not having re-staging CT scans</li>\n<li>Patients younger than 18 years old</li>\n</ul>\n', created = 1283568595, expire = 1283654995, headers = '', serialized = 0 WHERE cid = '1:67e4713599de84d2acd30c14dcd23425' in /persistent/html/includes/cache.inc on line 109.

Delayed Nausea and Vomiting in Patients With Colorectal Cancer Receiving Standard Anti-Vomiting Medicine During the First Course of Chemotherapy

Recruitment status:

Completed

RATIONALE: Learning how often patients experience nausea and vomiting after receiving anti-vomiting medicine and chemotherapy for colorectal cancer may help doctors plan better treatment and improve patients' quality of life. PURPOSE: This clinical trial is studying delayed nausea and vomiting in patients with colorectal cancer receiving standard anti-vomiting medicine during the first course of chemotherapy.

Background information

Trial ID:

NCT00729677

Other unique IDs:

CDR0000599895

BIMCP-NV-SURVEY

BIMCP-IRB-37-04

MERCK-BIMCP-NV-SURVEY

Official title:

Prevalence of Delayed Nausea and Vomiting in Patients Being Treated With Oxaliplatin-Based Regimens (mFOLFOX6 or FOLFOX7) for Colorectal Cancer

Detailed description:

OBJECTIVES:

To assess the prevalence of delayed nausea and vomiting in patients with colorectal cancer receiving standard anti-emetic medications during the first course of an oxaliplatin-based chemotherapy regimen (mFOLFOX6 or FOLFOX7).

Number to be enrolled:

100 patients

Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Stage IIA, Stage IIIA, or Stage IIIB Rectal Cancer

Trial phase:

Phase III

Recruitment status:

Recruiting

RATIONALE: Laparoscopic-assisted resection is a less invasive type of surgery for rectal cancer and may have fewer side effects and improve recovery. It is not yet known whether laparoscopic-assisted resection is more effective than open resection in treating patients with rectal cancer. PURPOSE: This randomized phase III trial is studying laparoscopic-assisted resection to see how well it works compared with open resection in treating patients with stage IIA, stage IIIA, or stage IIIB rectal cancer.

Background information

Trial ID:

NCT00726622

Other unique IDs:

CDR0000601816

ACOSOG-Z6051

Official title:

A Phase III Prospective Randomized Trial Comparing Laparoscopic-Assisted Resection Versus Open Resection for Rectal Cancer

Detailed description:

OBJECTIVES: Primary

To test the hypothesis that laparoscopic-assisted resection is not inferior to open resection, based on a composite primary endpoint of oncologic factors that are indicative of a safe and feasible surgical resection, in patients with stage IIA, IIIA, or IIIB rectal cancer.

Number to be enrolled:

650 patients

FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer

Trial phase:

Phase III

Recruitment status:

Recruiting

This study is a randomized multi-center trial that will assess the effect of adding SIRT, using SIR-Spheres microspheres, to a standard chemotherapy regimen of FOLFOX as first line therapy in patients with non-resectable liver metastases from primary colorectal adenocarcinoma.

Background information

Trial ID:

NCT00724503

Other unique IDs:

STX0206

Official title:

Randomised Comparative Study Of Folfox6m Plus Sir-Spheres® Microspheres Versus Folfox6m Alone As First Line Treatment In Patients With Nonresectable Liver Metastases From Primary Colorectal Carcinoma

Detailed description:

Number to be enrolled:

318 patients

Acronym:

SIRFLOX

Allogeneic Whole Cell Cancer Vaccine for Metastatic Epithelial Tumors

Trial phase:

Phase I

Recruitment status:

Not yet recruiting

This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with colorectal, gastric, ovarian, breast or lung epithelial cancer. Tumor cells grown in the laboratory will be modified to make them stimulatory to the immune system, irradiated to kill them, and injected to the patient eight times at two-week intervals . This protocol is expected to prolong survival of metastatic epithelial cancer patients.

Background information

Trial ID:

NCT00722228

Other unique IDs:

0359-08-HMO-CTIL

Official title:

Detailed description:

Number to be enrolled:

0 patients

Randomized Phase II Study of SOL for Untreated Metastatic Colorectal Cancer

Trial phase:

Phase II

Recruitment status:

Recruiting

This is a randomized, multicenter study designed to evaluate the progression free survival of the SOL group (S-1, Leucovorin, and Oxaliplatin) compared with the mFOLFOX6 group (5-FU, l-LV and Oxaliplatin) as first-line treatment of patients with metastatic colorectal cancer.

Background information

Trial ID:

NCT00721916

Other unique IDs:

Taiho10020390

Official title:

Randomized Phase II Study of S-1, Oral Leucovorin, and Oxaliplatin Combination Therapy (SOL) Versus 5-FU, l-LV and Oxaliplatin Combination Therapy (mFOLFOX6) in Patients With Untreated Metastatic Colorectal Cancer

Detailed description:

Number to be enrolled:

106 patients

Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Who Have Received First-Line Chemotherapy and Bevacizumab

Trial phase:

Phase III

Recruitment status:

Recruiting

RATIONALE: Drugs used in chemotherapy, such as irinotecan, oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether combination chemotherapy is more effective with or without bevacizumab in treating metastatic colorectal cancer. PURPOSE: This randomized phase III trial is studying second-line combination chemotherapy to see how well it works compared with or without bevacizumab in treating patients with metastatic colorectal cancer who have received first-line chemotherapy and bevacizumab.

Background information

Trial ID:

NCT00720512

Other unique IDs:

CDR0000598567

GONO-BEBYP-ASL607LIOM03

GONO-AIFA - FARM5C4FB4

EUDRACT:2007-002886-11

Official title:

AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE III STUDY OF SECOND-LINE CHEMOTHERAPY WITH OR WITHOUT BEVACIZUMAB IN METASTATIC COLORECTAL CANCER PATIENTS WHO HAVE RECEIVED FIRST-LINE CHEMOTHERAPY PLUS BEVACIZUMAB.

Detailed description:

OBJECTIVES: Primary

To compare the progression-free survival of second-line chemotherapy with or without bevacizumab in patients with metastatic colorectal cancer who have received first-line chemotherapy with bevacizumab.

Secondary

To compare the overall survival, response rate, and safety profile of second-line chemotherapy of these regimens in these patients.
To conduct pharmacogenomics assessment of candidate variants in the VEGF gene and evaluate their association with progression-free survival and other study outcomes.

Number to be enrolled:

262 patients

Combination Chemotherapy and Bevacizumab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Trial phase:

Phase III

Recruitment status:

Recruiting

RATIONALE: Drugs used in chemotherapy, such as irinotecan, oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving combination chemotherapy together with bevacizumab may kill more tumor cells. PURPOSE: This randomized phase III trial is comparing two combination chemotherapy regimens given together with bevacizumab to see how well they work as first-line therapy in treating patients with metastatic colorectal cancer that cannot be removed by surgery.

Background information

Trial ID:

NCT00719797

Other unique IDs:

CDR0000598582

GONO-TRIBE

ASL608LIOM04

EUDRACT:2008-001537-10

Official title:

A Phase III Randomized Trial of FOLFOXIRI + Bevacizumab Versus FOLFIRI + Bevacizumab as First- Line Treatment for Metastatic Colorectal Cancer.

Detailed description:

OBJECTIVES: Primary

To compare the progression-free survival of bevacizumab in combination with oxaliplatin, irinotecan hydrochloride, fluorouracil, and leucovorin calcium (FOLFOXIRI) versus bevacizumab in combination with irinotecan hydrochloride, fluorouracil, and leucovorin calcium (FOLFIRI) in patients with unresectable, metastatic colorectal cancer.

Number to be enrolled:

450 patients

Study of Irinotecan Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer

Trial phase:

Phase I

Recruitment status:

Recruiting

Open-label phase 1b trial. Study treatment will be administered in 3 week cycles. There are two distinct parts in this study:

Part 1: Dose escalation from IMO-2055
Part 2: Once a recommended phase 2 dose is found additional tolerability and pharmacodynamics will be explored

Background information

Trial ID:

NCT00719199

Other unique IDs:

IMO-2055-210

Official title:

Open-Label Phase 1b Study of Irinotecan Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer Who Have Progressed Following Chemotherapy for Advanced or Metastatic Disease

Detailed description:

Part 1: Dose escalation of IMO-2055, including 4 dose groups. Once a recommended phase 2 dosage (RP2D) of IMO-2055 given concomitantly with irinotecan and cetuximab is found the selected cohort will be expanded by an additional 6 to 9 patients (to a total of 12 patients) for confirmation of the RP2D and combination treatment regimen.
Part 2: A final cohort of 12 patients (Cohort 6) will be enrolled simultaneously to explore tolerability and pharmacodynamics in patients treated with the RP2D of IMO-2055 in combination with irinotecan with cetuximab.

Number to be enrolled:

50 patients

Evaluation of the Incidence of Nausea and Vomiting in Patients With Colorectal Cancer Receiving Irinotecan-Based Therapy

Recruitment status:

Recruiting

This is a study to determine how much nausea and or vomiting is caused by irinotecan-based chemotherapy in patients with colorectal cancer. Patients with colorectal cancer scheduled to receive their first cycle of an irinotecan-based chemotherapy regimen are eligible. Any chemotherapy agents administered in combination with irinotecan must have low-minimal potential to cause nausea and or vomiting. Examples of acceptable regimens would be irinotecan in combination with infusional fluorouracil and leucovorin (FOLFRI) with or without bevacizumab and irinotecan in combination with cetuximab. Patients who have received prior non-irinotecan-based chemotherapy are eligible providing they experienced no vomiting and no greater than mild nausea with their prior chemotherapy.

Background information

Trial ID:

NCT00713128

Other unique IDs:

00455

Official title:

Prospective Evaluation of the Incidence of Nausea and Vomiting in Patients With Colorectal Cancer Receiving Irinotecan-Based Therapy

Detailed description:

Irinotecan is a camptothecin analog which exerts its cytotoxic effects by forming a covalent complex with topoisomerase I and DNA, resulting in inhibition of DNA re-ligation, accumulation of DNA double strand breaks and apoptotic cell death (1). Irinotecan is FDA approved for use in the front-line and second-line treatment of colorectal cancer. It has also demonstrated activity in a variety of other non-hematologic tumors. The recently updated ASCO antiemetic guidelines characterize irinotecan as having moderate emetic risk. (2).

Number to be enrolled:

50 patients

Study of the Therapeutic Use of Language in Patients With Metastatic Colorectal Cancer

Recruitment status:

Recruiting

The purpose of this study is to determine if the degree of agreement between patients and their physicians regarding the "story" of the illness correlates with improved patient symptom control and quality of life. Another goal of the study is to examine the actual language used by patients and physicians in a specific clinical situation.

Background information

Trial ID:

NCT00711672

Other unique IDs:

808231

Official title:

Critical Negotiations: Narrative Agreement, Negotiation, and Register Use in Encounters Between Patients With Metastatic Colorectal Carcinoma and Their Oncologists

Detailed description:

The purpose of this study is to investigate the co-created therapeutic narrative in scheduled office visits between adult patients with metastatic colorectal carcinoma and their medical oncologists in a community practice setting. The study will focus on the negotiation of the illness narrative and the semiotic (primarily linguistic) tools employed. The study will involve patients from a large community cancer center from Northeastern Pennsylvania (this center sees about 3,000 new patients each year).

Number to be enrolled:

18 patients

Search clinical trials

Colorectal Cancer

Delayed Nausea and Vomiting in Patients With Colorectal Cancer Receiving Standard Anti-Vomiting Medicine During the First Course of Chemotherapy

Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Stage IIA, Stage IIIA, or Stage IIIB Rectal Cancer

FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer

Allogeneic Whole Cell Cancer Vaccine for Metastatic Epithelial Tumors

Randomized Phase II Study of SOL for Untreated Metastatic Colorectal Cancer

Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Who Have Received First-Line Chemotherapy and Bevacizumab

Combination Chemotherapy and Bevacizumab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Study of Irinotecan Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer

Evaluation of the Incidence of Nausea and Vomiting in Patients With Colorectal Cancer Receiving Irinotecan-Based Therapy

Study of the Therapeutic Use of Language in Patients With Metastatic Colorectal Cancer

Conditions

Clinical trial sponsors

User login

Study design