Brain and Central Nervous System Tumors

  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:20a7014f098a91968d77b9343e1c29d8' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as arsenic trioxide and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Arsenic trioxide and temozolomide may also make tumor cells more sensitive to radiation therapy. Giving radiation therapy together with combination chemotherapy may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of arsenic trioxide when given together with temozolomide and radiation therapy in treating patients with newly diagnosed high-grade glioma.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:20a7014f098a91968d77b9343e1c29d8' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Maximum tolerated dose of arsenic trioxide [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:a4948bb7569710e367b06428696ed455' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Dose-limiting toxicities as measured by CTCAE version 3.0 [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:2aa1cc01c839a139b9ce9e3b5c3402dc' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e66306c2f17fd13e2520dffb67ab8cfa' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving bevacizumab together with erlotinib may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving bevacizumab together with erlotinib works after radiation therapy and temozolomide in treating patients with newly diagnosed glioblastoma multiforme or gliosarcoma.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:e66306c2f17fd13e2520dffb67ab8cfa' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Safety [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:cdb346abfbb13f4616a27fe69d0ba554' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Progression-free survival at 12 and 24 months [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:4f5b4b40f44438c68f8705460ce70861' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Radiographic response rates [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:84527f4e2b9a2001eaf4200ea46a7e1c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Sodium thiosulfate may reduce or prevent hearing loss in young patients receiving cisplatin for cancer. It is not yet known whether sodium thiosulfate is more effective than no additional treatment in preventing hearing loss. PURPOSE: This randomized phase III trial is studying sodium thiosulfate to see how well it works compared with no additional treatment in preventing hearing loss in young patients receiving cisplatin for newly diagnosed germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, or osteosarcoma.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:aacaf76024ee20677936184433c1ffeb' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:265105321875dcf0139d99431c789d78' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES: Primary\n<ul>\n<li>To compare the efficacy of sodium thiosulfate vs observation in preventing hearing loss in young patients receiving cisplatin for the treatment of newly diagnosed germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, or osteosarcoma.</li>\n</ul>\n</p><p> Secondary\n<ul>\n<li>To compare the mean change in hearing thresholds for key frequencies in these patients.</li>\n<li>To compare the incidences of cisplatin-related grade 3 and 4 nephrotoxicity and grade 3 and 4 cytopenia in these patients.</li>\n<li>To compare the event-free survival and overall survival of these patients.</li>\n</ul>\n</p><p> OUTLINE: This is a multicenter study. Patients are stratified according to age (&lt; 5 years vs &#8805; 5 years) and duration of cisplatin infusion (&lt; 2 hours vs &#8805; 2 hours). Patients are randomized to 1 of 2 arms.\n<ul>\n<li>Arm I (sodium thiosulfate): Patients receive sodium thiosulfate IV over 15 minutes beginning 6 hours after the completion of each cisplatin infusion.</li>\n</ul>\n</p><p> Treatment with sodium thiosulfate continues until the completion of cisplatin therapy.\n<ul>\n<li>Arm II (observation): Patients do not receive sodium thiosulfate. Patients undergo audiological assessment at baseline, prior to each course of cisplatin, and then at 4 weeks and 1 year after the last course of cisplatin or other cancer treatment.</li>\n</ul>\n</p><p> After completion of study, patients are followed periodically for 10 years.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:b398d3dbad0909673f022c76b018e5a0' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, or osteosarcoma</li>\n<li>Newly diagnosed disease (previously untreated or currently receiving cancer treatment for the diagnosis that made the patient eligible for this study)</li>\n<li>Planning to receive a chemotherapy treatment regimen that includes a cumulative cisplatin dose &#8805; 200 mg/m&#178; with individual cisplatin doses to be infused over &#8804; 6 hours</li>\n<li>Enrolled on hearing assessment clinical trial COG-ACCL05C1\n<ul>\n<li>Normal auditory results</li>\n</ul>\n</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>Karnofsky performance status (PS) 50-100% (for patients &gt; 16 years of age)</li>\n<li>Lansky PS 50-100% (for patients &#8804; 16 years of age)</li>\n<li>Serum sodium normal</li>\n<li>Absolute granulocyte count &gt; 1,000/mm&#179;</li>\n<li>Platelet count &gt; 100,000/mm&#179;</li>\n<li>Creatinine clearance or radioisotope glomerular filtration rate &#8805; 70mL/min OR serum creatinine between 0.4 and 1.7 mg/dL, based on age and gender</li>\n<li>Total bilirubin &#8804; 1.5 times upper limit of normal (ULN) for age</li>\n<li>AST or ALT &lt; 2.5 times ULN for age</li>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test (if patient has child-bearing capacity)</li>\n<li>Fertile patients must use effective contraception</li>\n<li>No known hypersensitivity to sodium thiosulfate or other thiol agents (e.g., amifostine trihydrate, N-acetylcysteine, MESNA, or captopril)</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n<li>No prior platinum-based chemotherapy (cisplatin or carboplatin)\n<ul>\n<li>Other prior chemotherapy allowed</li>\n</ul>\n</li>\n<li>No prior radiotherapy that included the cochlea in the radiation field (whole brain, posterior fossa, or brain stem/pons region)</li>\n<li>At least 6 months since prior hematopoietic stem cell transplantation\n<ul>\n<li>No evidence of graft-versus-host disease</li>\n</ul>\n</li>\n<li>No concurrent enrollment on another COG clinical trial for treatment of the cancer\n<ul>\n<li>Concurrent enrollment on a non-COG clinical trial (e.g., Headstart) allowed</li>\n</ul>\n</li>\n<li>No concurrent cranial irradiation during the chemotherapy regimen (i.e., prior to the administration of the final dose of cisplatin)\n<ul>\n<li>Cranial irradiation after the completion of all systemic chemotherapy allowed provided post end-of-treatment audiometry is completed prior to beginning irradiation</li>\n</ul>\n</li>\n<li>Concurrent radiotherapy to extracranial sites allowed</li>\n</ul>\n</p>', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:73c749e4d5acdf66f0b8c68dfe9ac7a4' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Overall survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Incidences of cisplatin-related grade 3 and 4 nephrotoxicity and grade 3 and 4 cytopenia [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:9a088597c83ae5028c8d2c5f087857b5' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Event-free-survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:7aa6888965c01226c0e13033f4c4ee2e' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. PURPOSE: This phase II trial is studying how well sunitinib works in treating patients with recurrent malignant glioma.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:5778960e09c4a7075d4d3eb83704adef' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Correlation between response to treatment with sunitinib malate and changes in brain FDG-PET and perfusion MRI [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:c8e8cddb1f2eb6aa949fcd4c827a2892' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Gathering health information about patients with neurofibromatosis type 1 over time may help doctors learn more about the disease. PURPOSE: This clinical trial is studying changes over time in patients with neurofibromatosis type 1 and their healthy siblings.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:8de74c2be29c6ed0a649e17dc6daee6d' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults With Neurofibromatosis Type 1</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:8ee5f052b2b1d7798436a14e9d312e39' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES:\n<ul>\n<li>To serve as an umbrella protocol for the ongoing neurofibromatosis type 1 (NF1) clinical trials program to longitudinally characterize and analyze NF1-related tumor and non-tumor manifestations and to develop a better understanding of the biology of NF1-related manifestations.</li>\n<li>To provide the basis for the development of endpoints for clinical trials and to potentially develop more effective treatments.</li>\n<li>To evaluate whole-body tumor burden in children with plexiform neurofibromas (PN) longitudinally.</li>\n<li>To analyze growth rate of PN in children and young adults over time.</li>\n<li>To evaluate fludeoxyglucose F 18 (FDG)-positron emission tomography (PET) in rapidly growing or painful PN, especially the utility of FDG-PET to differentiate benign PN from malignant peripheral nerve sheath tumors (MPNST).</li>\n<li>To analyze the location and growth rate of paraspinal neurofibromas over time using volumetric MRI analysis and 1-dimensional and 2-dimensional measurements.</li>\n<li>To evaluate the development and growth rate of dermal neurofibromas using digital photography, volume photography, and digital dermoscopy.</li>\n<li>To evaluate the development, number, and size of caf&#233;-au-lait spots using digital photography, digital dermoscopy, and a colorimeter.</li>\n<li>To evaluate the development and number of Lisch nodules longitudinally using slit-lamp examinations.</li>\n<li>To evaluate the utility of FDG-PET in the diagnosis of MPNST and in the evaluation of response to chemotherapy, which is not administered as part of this protocol.</li>\n<li>To evaluate patients with optic pathway gliomas (OPG) longitudinally by detailed opthalmological examination, proton magnetic resonance spectroscopic imaging (_1H-MRSI), diffusion tensor MRI (DT-MRI), and perfusion MRI.</li>\n<li>To evaluate changes in biochemical and metabolic imaging of OPG longitudinally using multivoxel spectroscopy and FDG-PET (on protocol NCI-03-C-0278, principal investigator Kathy Warren, or other subsequent studies as appropriate).</li>\n<li>To monitor and evaluate cardiac function at baseline in all individuals and cardiac and pulmonary function longitudinally in individuals with NF1 and clinical findings.</li>\n<li>To evaluate hearing at baseline and longitudinally in all individuals and as clinically indicated.</li>\n<li>To evaluate individuals longitudinally for scoliosis, other bony abnormalities, bone mineral density, and dental findings.</li>\n<li>To evaluate and longitudinally follow patients with NF1 and infrequent or unusual NF1 manifestations.</li>\n</ul>\n</p><p> OUTLINE: This is a multicenter study. Patients undergo a comprehensive baseline evaluation including clinical phenotyping, genotyping, imaging of tumor manifestations, and pain, quality of life, neuropsychological, motor, and endocrine evaluations. Unaffected siblings (controls) also undergo some of these evaluations. Skin and tumor manifestations are evaluated with a variety of imaging techniques including digital photography, volume photography, digital dermoscopy, fludeoxyglucose F 18-positron emission tomography (FDG-PET), and MRI. In addition, patients undergo evaluation for pain, neuropsychological function, motor function, and endocrine abnormalities. Cognitive and social-emotional function are evaluated at baseline and then periodically in patients and unaffected siblings (controls). Patients are followed for NF1 manifestations periodically ranging from every six months to every three years for approximately 10 years.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:4e7c76cc89da9baf05b63e2ef917e7e9' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Diagnosed with neurofibromatosis type 1 (NF1)* with &#8805; 2 or more of the following diagnostic criteria:\n<ul>\n<li>Six or more caf&#233;-au-lait spots (&#8805; 0.5 cm in prepubertal subjects or &#8805; 1.5 cm in postpubertal subjects)</li>\n<li>At least 2 neurofibromas or 1 plexiform neurofibroma</li>\n<li>Freckling in the axilla or groin</li>\n<li>Optic glioma</li>\n<li>Two or more Lisch nodules</li>\n<li>A distinctive bony lesion (dysplasia of the sphenoid bone or dysplasia or thinning of long bone cortex)</li>\n<li>A first-degree relative with NF1</li>\n</ul>\n</li>\n<li>If participating in the evaluation for variation in gene expression, patient must meet the following criteria:\n<ul>\n<li>Have at least 1 plexiform neurofibroma and be able to undergo MRI analysis of the plexiform neurofibroma(s)</li>\n<li>If possible, 1 or both biologic parents (NF1 affected or not) willing to donate blood or a cheek swab or mouthwash sample NOTE: *NF1 mutation testing to confirm eligibility will not be performed on this protocol but as part of a separate screening study. Histologic confirmation of NF1-related benign tumors is not necessary in the presence of consistent clinical and radiographic findings, but is required for individuals with malignant peripheral nerve sheath tumor (MPNST) who enroll on this study.</li>\n</ul>\n</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>ECOG 0-3</li>\n<li>Must meet 1 of the following age criteria:\n<ul>\n<li>May be up to 35 years of age for new patients evaluated at NIH</li>\n<li>No upper age limit for patients previously enrolled on clinical trials at NIH or for patients diagnosed with MPNST or with infrequent or unusual NF1-related manifestations</li>\n</ul>\n</li>\n<li>Must be able to obtain an MRI scan\n<ul>\n<li>Individuals who are pregnant or breast feeding or who become pregnant while enrolled on this trial will not be excluded from participation, but will not undergo radiographic evaluations or MRI scans requested for research purposes, or other studies that might negatively impact on the pregnancy</li>\n</ul>\n</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>Prior medical or surgical treatment for NF1 allowed</li>\n<li>Concurrent medical and/or radiological treatment for NF1 allowed</li>\n</ul>\n</p>', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:64568f4f58237d99ca5558d98bf0fc5c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Quality of life [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:fda837c2e4537dcece1f29e3be5f39c3' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Pain and peripheral neuropathy [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:2f33232861c7d8b79695aa84426fdf48' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:abe946e3ea1223b40e96f624b25933fd' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Neuropsychological function [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:abe946e3ea1223b40e96f624b25933fd' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:cbf0c4513881308c0f63c6ef751c9f7e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Motor function [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:cbf0c4513881308c0f63c6ef751c9f7e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6c991df14ef85881feb1cb8c2094e4b7' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Endocrinology [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:6c991df14ef85881feb1cb8c2094e4b7' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a0336bbab35ea4e850fa058549535eb3' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Cardiopulmonary function [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:a0336bbab35ea4e850fa058549535eb3' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f23d82d225718f907d0554fb8fcb9bad' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Hearing [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:f23d82d225718f907d0554fb8fcb9bad' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:071f1b43c9f2ce1d0e258cca8d202e43' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Bony abnormalities [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:071f1b43c9f2ce1d0e258cca8d202e43' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d46de60ceb1eb833ccce17ccf83e45a0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Infrequent or unusual NF1 manifestations [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:d46de60ceb1eb833ccce17ccf83e45a0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:9213b2c1751a86643645ee32a72afe4b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Gathering information about how young patients with ependymoma respond to standard combination chemotherapy and learning about the long-term effects of this treatment may help doctors plan better treatment. PURPOSE: This phase III trial is observing young patients with ependymoma undergoing standard combination chemotherapy.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:9213b2c1751a86643645ee32a72afe4b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:79d982c89fe60206aacfe5a272aa6d89' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>CCLG Observational Study of the Outcome of Ependymoma in Infants Diagnosed Before Their Third Birthday</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:79d982c89fe60206aacfe5a272aa6d89' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d30bdb9e735cfffd645642aeca09a22c' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES: Primary\n<ul>\n<li>To determine the overall survival and event-free survival of all infants diagnosed with ependymoma before their third birthday.</li>\n<li>To determine the overall survival and event-free survival of infants diagnosed with ependymoma before their third birthday when treated with standard chemotherapy comprising vincristine, carboplatin, high-dose methotrexate, cyclophosphamide, and cisplatin.</li>\n</ul>\n</p><p> Secondary\n<ul>\n<li>To investigate the reasons why the primary tumor was completely resected in patients who were able to undergo complete resection of the tumor.</li>\n<li>To continue to investigate the biological characteristics of ependymoma.</li>\n<li>To correlate functional imaging studies of ependymoma with biological characteristics of the tumor.</li>\n<li>To provide a standard treatment regimen for patients with residual disease after optimal surgery who have already participated in a phase II study.</li>\n<li>To prospectively document renal function, hearing, and neurocognitive late effects after completion of study treatment.</li>\n</ul>\n</p><p> OUTLINE: This is a multicenter study. Patients are stratified according to extent of prior surgical resection and presence of metastatic disease (complete resection of tumor vs metastatic disease at diagnosis vs no complete resection of tumor). Patients receive vincristine IV on days 1, 15, and 29, carboplatin IV over 1 hour on day 1, high-dose methotrexate* IV over 24 hours on day 15, cyclophosphamide IV over 1 hour on day 29, and cisplatin IV over 48 hours on days 43 and 44. Treatment repeats every 8 weeks for 7 courses in the absence of disease progression or unacceptable toxicity. Patients with residual disease after completion of treatment may receive other treatment at the discretion of the investigator. NOTE: *Patients initially treated on clinical trial CCLG-CNS-2005-03 who have no residual disease do not receive high-dose methotrexate in courses 5-7. Patients undergo observational assessments comprising physical and neurological examination; MRI/ MRS scanning of the head and spine; and audiology, renal, endocrine, neurocognitive, and quality of life evaluations periodically for at least 5 years after the completion of study treatment.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:d30bdb9e735cfffd645642aeca09a22c' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f7940bd4b32fd7f599adec47f06aab66' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed WHO grade 3 anaplastic (malignant) ependymoma or WHO grade 2 ependymoma, including the following variants:\n<ul>\n<li>Papillary</li>\n<li>Cellular</li>\n<li>Clear cell</li>\n<li>Tanycytic</li>\n</ul>\n</li>\n<li>No myxopapillary ependymoma, subependymoma, or ependymoblastoma</li>\n<li>Meets 1 of the following criteria:\n<ul>\n<li>Has undergone complete resection of the primary tumor (prior to starting chemotherapy)\n<ul>\n<li>Two or more surgical procedures to achieve complete resection allowed</li>\n</ul>\n</li>\n<li>Metastatic disease at diagnosis (with or without complete resection of the primary tumor)</li>\n<li>Unable to undergo complete resection of the primary tumor (with or without metastatic disease)</li>\n</ul>\n</li>\n<li>Patients with measurable residual disease (primary or metastatic disease) are eligible provided they undergo treatment on clinical trial CCLG-CNS-2005-03 prior to entering this study</li>\n<li>Has undergone surgical resection OR completed treatment on clinical trial CCLG-CNS-2005-03 within the past 3 weeks</li>\n<li>Patients who are unable to tolerate chemotherapy or who do not receive treatment according to the CCLG guidelines for ependymoma due to parental preference or recommendation from the treating physician are eligible</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>Able to tolerate IV hydration</li>\n<li>No active infection</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>See Disease Characteristics</li>\n</ul>\n</p>', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:f7940bd4b32fd7f599adec47f06aab66' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Overall survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:a9cf1b60cee59581ac836c2a5fd32de1' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1bce599b1714a60b9b39877139d332e3' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Event-free survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:1bce599b1714a60b9b39877139d332e3' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:391a1e140b2a114cdc3ec9539139c5c0' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Response to chemotherapy, if there is residual disease [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:391a1e140b2a114cdc3ec9539139c5c0' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:a891ae615c07edce93defe79bc55e3c5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Late effects of treatment (i.e., ototoxicity and nephrotoxicity at the completion of chemotherapy and neurocognitive outcomes at 5, 7, 11, and 16 years of age) [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:a891ae615c07edce93defe79bc55e3c5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:d7cff7acd97a7940c2f9926e40da286e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Cilengitide may stop the growth of tumor cells by blocking blood flow to the tumor. PURPOSE: This phase II trial is studying how well cilengitide works in treating younger patients with recurrent or progressive high-grade glioma that has not responded to standard therapy.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:d7cff7acd97a7940c2f9926e40da286e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:dec7ef9bc392dc21da98db174e735a2e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Cilengitide (EMD 121974) (IND# 59073) in Recurrent or Progressive and Refractory Childhood High-Grade Glioma</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:dec7ef9bc392dc21da98db174e735a2e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:e68b970df687ec74823f4cca4470516e' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>OBJECTIVES: Primary\n<ul>\n<li>To determine the objective response rate to cilengitide in younger patients with recurrent or progressive high-grade glioma that is refractory to standard therapy.</li>\n</ul>\n</p><p> Secondary\n<ul>\n<li>To estimate the distribution of time to progression, time to treatment failure, and time to death in these patients.</li>\n<li>To estimate the rate of toxicity, especially symptomatic intratumoral hemorrhage, in these patients.</li>\n</ul>\n</p><p> OUTLINE: This is a multicenter study. Patients receive cilengitide IV over 1 hour on days 1, 4, 8, 11, 15, 18, 22, and 25. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study therapy, patients are followed every 3 months for 2 years and then periodically for 3 years.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:e68b970df687ec74823f4cca4470516e' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:b0d00f77f9f8f95fa4a481655c4ccc55' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>DISEASE CHARACTERISTICS:\n<ul>\n<li>Histologically confirmed* primary CNS high-grade glioma, including any of the following:\n<ul>\n<li>Glioblastoma multiforme</li>\n<li>Anaplastic astrocytoma</li>\n<li>Anaplastic oligodendroglioma</li>\n<li>High-grade astrocytoma not otherwise specified (i.e., anaplastic ganglioglioma, anaplastic mixed glioma, or anaplastic mixed glioneuronal tumors)</li>\n<li>Gliosarcoma NOTE: *Histopathologic diagnosis at the time of initial presentation or recurrence is required</li>\n</ul>\n</li>\n<li>Recurrent or progressive disease that is refractory to standard therapy</li>\n<li>Radiographically documented measurable disease\n<ul>\n<li>Lesion must be at least twice the thickness of the image from which it is derived (e.g., 10 mm for a 5 mm slice thickness)</li>\n</ul>\n</li>\n<li>No diffuse pontine gliomas</li>\n<li>No evidence of prior CNS bleeding</li>\n</ul>\n</p><p> PATIENT CHARACTERISTICS:\n<ul>\n<li>Karnofsky performance status (PS) 50-100% (patients &gt; 16 years of age)</li>\n<li>Lansky PS 50-100% (patients &#8804; 16 years of age)</li>\n<li>Life expectancy &#8805; 8 weeks</li>\n<li>ANC &#8805; 1,000/&#956;L</li>\n<li>Platelet count &#8805; 100,000/&#956;L (transfusion independent)</li>\n<li>Hemoglobin &#8805; 8.0 g/dL (RBC transfusions allowed)</li>\n<li>Creatinine clearance or radioisotope glomerular filtration rate &#8805; 70mL/min OR serum creatinine based on age/gender as follows:\n<ul>\n<li>0.4 mg/dL (1 month to &lt; 6 months of age)</li>\n<li>0.5 mg/dL (6 months to &lt; 1 year of age)</li>\n<li>0.6 mg/dL (1 to &lt; 2 years of age)</li>\n<li>0.8 mg/dL (2 to &lt; 6 years of age)</li>\n<li>1.0 mg/dL (6 to &lt; 10 years of age)</li>\n<li>1.2 mg/dL (10 to &lt; 13 years of age)</li>\n<li>1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to &lt; 16 years of age)</li>\n<li>1.7 mg/dL (male) or 1.4 mg/dL (female) (&#8805; 16 years of age)</li>\n</ul>\n</li>\n<li>Total bilirubin &#8804; 1.5 times upper limit of normal (ULN) for age</li>\n<li>ALT and AST &#8804; 2.5 times ULN for age</li>\n<li>No evidence of dyspnea at rest</li>\n<li>No exercise intolerance</li>\n<li>Pulse oximetry &gt; 94%, if determination is clinically indicated</li>\n<li>Seizure disorder is allowed provided it is well-controlled with anticonvulsants</li>\n<li>No uncontrolled infection</li>\n<li>Not pregnant or nursing</li>\n<li>Negative pregnancy test</li>\n<li>Fertile patients must use effective contraception</li>\n</ul>\n</p><p> PRIOR CONCURRENT THERAPY:\n<ul>\n<li>Recovered from all prior therapy</li>\n<li>No more than two prior treatments for high-grade glioma (i.e., one initial treatment and one treatment for relapse)</li>\n<li>More than 2 weeks since prior myelosuppressive chemotherapy (&#8805; 6 weeks for nitrosoureas)</li>\n<li>At least 1 week since prior non-myelosuppressive chemotherapy, immunotherapy, or biologic therapy</li>\n<li>At least 2 weeks since prior local palliative radiotherapy (i.e., small port) to a symptomatic non-target lesion only</li>\n<li>At least 3 months since prior craniospinal radiotherapy</li>\n<li>At least 6 weeks since prior substantial bone marrow radiotherapy</li>\n<li>At least 6 months since prior allogeneic stem cell transplantation (SCT) or rescue\n<ul>\n<li>Patients who have undergone prior allogeneic SCT and who have graft-versus-host disease (GVHD) must have controlled GVHD that is &#8804; grade 2</li>\n</ul>\n</li>\n<li>At least 1 month since prior autologous SCT</li>\n<li>More than 1 week since prior growth factors (&gt; 3 weeks for pegfilgrastim [Neulasta&#174;])</li>\n<li>No other concurrent anticancer therapy, including chemotherapy or immunomodulating agents</li>\n<li>No other concurrent experimental agents or therapies</li>\n<li>No concurrent alternative or complimentary therapies</li>\n<li>No concurrent homeopathic medicines</li>\n<li>No concurrent nonsteroidal anti-inflammatory drugs (NSAIDs) or acetylsalicylic acid (aspirin)</li>\n<li>No concurrent steroids as anti-emetics</li>\n<li>Concurrent steroids for treatment of increased intracranial pressure allowed if on a stable or decreasing dose for &#8805; 1 week before study entry</li>\n<li>Concurrent radiotherapy to localized painful lesions allowed provided &#8805; 1 measurable lesion is not irradiated</li>\n</ul>\n</p>', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:b0d00f77f9f8f95fa4a481655c4ccc55' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ceeb73d1bba5fd69e67a84e4c6d79cb5' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Time to treatment failure [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:ceeb73d1bba5fd69e67a84e4c6d79cb5' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:6b92db1b1070ace1bcd56bb866cb8e7b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Time to death [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:6b92db1b1070ace1bcd56bb866cb8e7b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:71cfadbf296c0ebe22fada5ed24e0760' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Toxicity as assessed by NCI CTCAE v3.0 [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:71cfadbf296c0ebe22fada5ed24e0760' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:46605d4ba5383de9efc6c31dfe2eb3a6' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Time to tumor progression [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:46605d4ba5383de9efc6c31dfe2eb3a6' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:11e22de61fa0db34db75dd7d8a69f528' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Giving chemotherapy and radiation therapy before a peripheral stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as G-CSF, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. Chemotherapy or radiation therapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy and radiation therapy. PURPOSE: This phase I trial is studying the best dose of temozolomide when given together with radiation therapy, carmustine, O6-benzylguanine, and an autologous stem cell transplant in treating patients with newly diagnosed glioblastoma multiforme or gliosarcoma.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:11e22de61fa0db34db75dd7d8a69f528' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:64c94527c722c897a14033e356f8eb6b' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Time to progression [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:64c94527c722c897a14033e356f8eb6b' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ee28679e59cceacccdd3b0ead00a1752' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Duration of response [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:ee28679e59cceacccdd3b0ead00a1752' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:efe1e9871eb762bcbc63df4746bb8b44' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Dose-limiting toxicity (hematologic and nonhematologic) of temozolomide [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:efe1e9871eb762bcbc63df4746bb8b44' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:1dbdc8325cd2bf2d0d95f532bd00f287' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Development of replication competent retrovirus or leukemia [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:1dbdc8325cd2bf2d0d95f532bd00f287' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Tumor response by MRI or contrast-enhanced CT scan [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:3f3c7836b883ac43b6833051f70ee325' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:89b1f92db1517580228d9299d3389264' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Gene transfer efficiency and in vivo selection by gene marking in peripheral blood and marrow monthly [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:89b1f92db1517580228d9299d3389264' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:32228d9cca102b7ca086f18e00e5b481' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Chemoprotection in terms of the ability to increase the temozolomide dose [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:32228d9cca102b7ca086f18e00e5b481' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:f1bf99cb7fcf3f79a363468544593ec8' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Tandutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving tandutinib together with bevacizumab may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving tandutinib together with bevacizumab and to see how well it works in treating patients with recurrent high-grade glioma.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:f1bf99cb7fcf3f79a363468544593ec8' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:235d35a7792480f0d757eadceb7601b2' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>RATIONALE: Cediranib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving cediranib together with temozolomide and radiation therapy may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of cediranib to see how well it works when given together with temozolomide and radiation therapy in treating patients with newly diagnosed glioblastoma.</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:235d35a7792480f0d757eadceb7601b2' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:0e79568ecdbbf006d075c1c708fed460' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Progression-free survival [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:0e79568ecdbbf006d075c1c708fed460' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Safety profile and optimal dose of cediranib during chemoradiotherapy [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;Yes&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:0141408a90ec0cbb590e9fe919c70ba9' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>MRI parameters [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:0aab576ceb397a4fe2ea11d6407acd52' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Blood biomarkers [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283569437, expire = 1283655837, headers = '', serialized = 0 WHERE cid = '1:1945e6255433e18eece594b43a7d452b' in /persistent/html/includes/cache.inc on line 109.
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Radiation Therapy, Arsenic Trioxide, and Temozolomide in Treating Patients With Newly Diagnosed High-Grade Glioma

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as arsenic trioxide and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Arsenic trioxide and temozolomide may also make tumor cells more sensitive to radiation therapy. Giving radiation therapy together with combination chemotherapy may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of arsenic trioxide when given together with temozolomide and radiation therapy in treating patients with newly diagnosed high-grade glioma.

Background information
Other unique IDs: 
CDR0000600335
CHNMC-07058
CEPHALON-CHNMC-07058

Bevacizumab and Erlotinib After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving bevacizumab together with erlotinib may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving bevacizumab together with erlotinib works after radiation therapy and temozolomide in treating patients with newly diagnosed glioblastoma multiforme or gliosarcoma.

Background information
Other unique IDs: 
CDR0000598539
NU-07C3
GENENTECH-NU 07C3
NU-IRB-STU00002792

Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, or Osteosarcoma

Trial phase: 
Phase III
Recruitment status: 
Recruiting

RATIONALE: Sodium thiosulfate may reduce or prevent hearing loss in young patients receiving cisplatin for cancer. It is not yet known whether sodium thiosulfate is more effective than no additional treatment in preventing hearing loss. PURPOSE: This randomized phase III trial is studying sodium thiosulfate to see how well it works compared with no additional treatment in preventing hearing loss in young patients receiving cisplatin for newly diagnosed germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, or osteosarcoma.

Background information
Trial ID: 
NCT00716976
Other unique IDs: 
CDR0000588655
COG-ACCL0431
Official title: 

A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children

Detailed description: 

OBJECTIVES: Primary

  • To compare the efficacy of sodium thiosulfate vs observation in preventing hearing loss in young patients receiving cisplatin for the treatment of newly diagnosed germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, or osteosarcoma.

Number to be enrolled: 
120 patients

Sunitinib in Treating Patients With Recurrent Malignant Glioma

RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. PURPOSE: This phase II trial is studying how well sunitinib works in treating patients with recurrent malignant glioma.

Background information
Other unique IDs: 
CDR0000599821
NCI-08-C-0168
NCI-P07336

Studying Changes Over Time in Patients With Neurofibromatosis Type 1 and Their Healthy Siblings

Recruitment status: 
Recruiting

RATIONALE: Gathering health information about patients with neurofibromatosis type 1 over time may help doctors learn more about the disease. PURPOSE: This clinical trial is studying changes over time in patients with neurofibromatosis type 1 and their healthy siblings.

Background information
Trial ID: 
NCT00693394
Other unique IDs: 
CDR0000589012
NCI-08-C-0079
NCI-P07283
Official title: 

Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults With Neurofibromatosis Type 1

Detailed description: 

OBJECTIVES:

  • To serve as an umbrella protocol for the ongoing neurofibromatosis type 1 (NF1) clinical trials program to longitudinally characterize and analyze NF1-related tumor and non-tumor manifestations and to develop a better understanding of the biology of NF1-related manifestations.
  • To provide the basis for the development of endpoints for clinical trials and to potentially develop more effective treatments.
  • To evaluate whole-body tumor burden in children with plexiform neurofibromas (PN) longitudinally.
  • To analyze growth rate of PN in children and
Number to be enrolled: 
200 patients

Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy

Trial phase: 
Phase III
Recruitment status: 
Recruiting

RATIONALE: Gathering information about how young patients with ependymoma respond to standard combination chemotherapy and learning about the long-term effects of this treatment may help doctors plan better treatment. PURPOSE: This phase III trial is observing young patients with ependymoma undergoing standard combination chemotherapy.

Background information
Trial ID: 
NCT00683319
Other unique IDs: 
CDR0000590666
CCLG-CNS-2007-09
EU-20835
Official title: 

CCLG Observational Study of the Outcome of Ependymoma in Infants Diagnosed Before Their Third Birthday

Detailed description: 

OBJECTIVES: Primary

  • To determine the overall survival and event-free survival of all infants diagnosed with ependymoma before their third birthday.
  • To determine the overall survival and event-free survival of infants diagnosed with ependymoma before their third birthday when treated with standard chemotherapy comprising vincristine, carboplatin, high-dose methotrexate, cyclophosphamide, and cisplatin.

Number to be enrolled: 
50 patients

Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy

Trial phase: 
Phase II
Recruitment status: 
Suspended

RATIONALE: Cilengitide may stop the growth of tumor cells by blocking blood flow to the tumor. PURPOSE: This phase II trial is studying how well cilengitide works in treating younger patients with recurrent or progressive high-grade glioma that has not responded to standard therapy.

Background information
Trial ID: 
NCT00679354
Other unique IDs: 
CDR0000595623
COG-ACNS0621
Official title: 

Cilengitide (EMD 121974) (IND# 59073) in Recurrent or Progressive and Refractory Childhood High-Grade Glioma

Detailed description: 

OBJECTIVES: Primary

  • To determine the objective response rate to cilengitide in younger patients with recurrent or progressive high-grade glioma that is refractory to standard therapy.

Secondary

  • To estimate the distribution of time to progression, time to treatment failure, and time to death in these patients.
  • To estimate the rate of toxicity, especially symptomatic intratumoral hemorrhage, in these patients.

Number to be enrolled: 
24 patients

Temozolomide, Carmustine, O6-Benzylguanine, Radiation Therapy, and an Autologous Stem Cell Transplant in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

RATIONALE: Giving chemotherapy and radiation therapy before a peripheral stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as G-CSF, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. Chemotherapy or radiation therapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy and radiation therapy. PURPOSE: This phase I trial is studying the best dose of temozolomide when given together with radiation therapy, carmustine, O6-benzylguanine, and an autologous stem cell transplant in treating patients with newly diagnosed glioblastoma multiforme or gliosarcoma.

Background information
Other unique IDs: 
CDR0000586180
FHCRC-2000.00
FHCRC-IR-6259

Tandutinib and Bevacizumab in Treating Patients With Recurrent High-Grade Glioma

RATIONALE: Tandutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving tandutinib together with bevacizumab may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving tandutinib together with bevacizumab and to see how well it works in treating patients with recurrent high-grade glioma.

Background information
Other unique IDs: 
CDR0000594111
NCI-08-C-0101
P07260

Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

RATIONALE: Cediranib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving cediranib together with temozolomide and radiation therapy may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of cediranib to see how well it works when given together with temozolomide and radiation therapy in treating patients with newly diagnosed glioblastoma.

Background information
Other unique IDs: 
CDR0000593717
MGH-07-344
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