Asthma

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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to identify community resources and challenges in improving the health of community members with asthma. The primary goal of this project is to use Community-Based Participatory Research methodology to develop interventions aimed at improving asthma management in high-risk African American asthmatics. This &quot;ground-up&quot; longterm approach has never been tested before in asthmatics. The primary goal of this study will be accomplished with four specific aims: Aim 1. Conduct focus groups to identify barriers to asthma management in the target population. Aim 2. Use a community advisory board (CAB) consisting of participants selected from the various focus groups to gather information about solutions for the above barriers. Aim 3. Use the information from the CAB to develop an intervention to improve asthma self management behaviors in the target population. Aim 4. Refine the developed intervention based on feedback from focus groups conducted in Aim 1.</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:2de1088f49b255abf495074282c41fb4' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Feasibility of Developing an Effective Asthma Intervention Using CBPR Methods</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:3b2bc1bc84c67505a521bb5c32767dfb' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Volunteer will be asked to respond to several questions that address their perceptions about asthma. Volunteers will also be asked to discuss their beliefs about asthma. Everyone in the group will be given an opportunity to answer questions. Volunteers can decide that they no longer want to participate in the group discussion at any time. The discussion will last from 1.5 - 2 hours. The focus group discussion will have a maximum of 10 people. We will be audio and video taping the discussion so that we do not miss any information that volunteers share with us. The audio and video tapes will not be shared with anyone outside our staff. Volunteer participation in this study is voluntary and there will be no negative consequences if volunteers decide not to participate. Volunteers are also free to withdraw from this study at any time. Withdrawal or refusal to participate will not affect health care services or other rights.</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:80e745a210ef7e9ef104a9f893cf6fa5' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Self-identified African-American, 18 yrs. or older, resident of Davidson County, Tennessee at least 1 year.</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Under 18 yrs. of age</li>\n<li>Non-African American</li>\n<li>Non-English speaking</li>\n<li>Do not reside in Davidson County, Tennessee</li>\n</ul>\n</p>', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:eb03fb80272c26ecc11a2794c55bd891' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to evaluate the effect of IMA-026, an antibody to IL-13, on airway hyperresponsiveness and airway inflammation in mild asthmatics. IMA-026 will be given as 2 injections under the skin 1 week apart at 2 mg/kg each dose. The study will include a screening period and a treatment period which includes doses on day 1 and day 8.</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:819b9a9d7fdc68e56efb9ee907324b1b' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The Effects of IMA-026 on Allergen-Induced Airway Responses and Airway Inflammation in Subjects With Mild Atopic Asthma</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:dace67df21e2f6d2cab438fd042c2455' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ol>\n<li>Healthy men and women 18 to 60 yrs with mild allergic asthma</li>\n<li>only asthma med is short-acting bronchodilator used not more than twice weekly</li>\n<li>FEV1 greater than 70% predicted and a demonstrated baseline late response to allergen induction</li>\n</ol>\n</p><p> Exclusion Criteria:\n<ol>\n<li>Upper respiratory infection or asthma exacerbation with 4 weeks of screening</li>\n<li>Serious infection requiring parenteral antibiotics or hospitalization with 4 weeks of test article administration</li>\n<li>Positive radiographic findings indicative of respiratory disease other than asthma</li>\n</ol>\n</p>', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:14bfa91b82d50183e5d16349bb8d5930' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Study to determine the bronchodilatory effects of PF-04191834 compared with zileuton in patients with asthma</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:64908f124fe0c710a1e28b71c969c0ad' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>A Phase 2a, Randomised, Double-Blind (3rd Party Open), Double-Dummy, Placebo And Active Controlled 5-Way Crossover Study To Assess The Bronchodilatory Action, Safety, Toleration And Pharmacokinetics Of Single Oral Doses Of PF-04191834 In Asthmatic Patient</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:7970dc555aa34a97dfa0b31e4a5ce405' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Persistent mild/moderate asthma for at least 6 months.</li>\n<li>Reduced lung function</li>\n<li>Reversible airway obstruction</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Pregnant/nursing females.</li>\n<li>Liver function tests greater than upper limit of normal (ULN)</li>\n</ul>\n</p>', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:d49c78882f9cc62647cc30810262814a' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Pharmacokinetics [&nbsp;Time&nbsp;Frame:&nbsp;24 hours&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:9bb1aba1c1a677eac9eb7f307732d848' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Duration and number of doses of bronchodilator therapy [&nbsp;Time&nbsp;Frame:&nbsp;Day&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:f208ba540d0c9bb46b1deccff1b2cdab' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The main aim of the study is to develop a method that allows responders to be distinguished from non-responders before long-term treatment is initiated. Subsidiary aims are to record changes in pulmonary functional parameters, NO concentrations and peak flow variability, the use of beta2 sympathomimetics and the asthma symptom score.</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:f8e76648f84c4428ede5cd563c7ac8a9' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Investigation to Identify Predictors of Response to a Treatment With Montelukast</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:a789b9d798774256d6bb728f1eb95c81' in /persistent/html/includes/cache.inc on line 109.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_filter WHERE cid = '1:ae4603f3fc5a99089bfc5c5d23cd2f12' in /persistent/html/includes/cache.inc on line 26.
  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Leukotriene antagonists (montelukast) are particularly effective as controllers before exposure to an allergen (Leff 1998). The same applies to the treatment of bronchoconstriction induced by physical exertion or cold air (Richter 2000). Montelukast binds to the cysteinyl leuko&#172;triene-1 receptor, where it prevents leukotriene from binding. Leukotrienes play a key role as mediators in inflammatory processes. By binding to the receptor they cause, among other things, edema, damage to the bronchial epithelium and bronchoconstriction. Accordingly, in addition to its anti-inflammatory activity montelukast brings about bronchial dilation. The safety and efficacy of the drug in children have been well documented (Knorr 1998). Hence montelukast is approved for the treatment of bronchial asthma in children (over six months of age). As with other antiasthmatic drugs, there are responders and nonresponders to leukotriene receptor antagonists. The proportion of nonresponders to montelukast among children is esti&#172;mated to be 30% to 40%. At present the only way to distinguish non-responders from responders is to run a treatment trial for several weeks. If the symptom score falls, if the use of beta2 sympathomimetics is reduced, if pulmonary function and/or the quality of life improves, it is assumed that the patient is a responder. This method is not only tedious but also unsafe, since a change is the aforementioned parameters could occur spontaneously, without this being reliably attributable to the influence of the drug. In the planned study approximately 30 children with asthma of GINA classes 2 and 3 will be regularly examined for pulmonary function, symptom score and nitrogen monoxide (NO). First, however, the acute pharmacologic effect of a single dose of montelukast will be deter&#172;mined over a period of four hours by measuring pulmonary function and levels of exhaled nitrogen monoxide (NO). 4.2.1. Questions addressed: Is it possible to discriminate between responders and nonresponders at a very early stage on the basis of the acute pharmacologic effect of montelukast? Does this classification agree with the results after 12 weeks of treatment? 4.2.2. Hypothesis: Patients who show a bronchospasmolytic effect in their functional pulmonary test (FEV1 increased by at least 5%) within four hours of taking montelukast also show a positive response (defined as a combination of at least two variables (see section on the definition of responders/non-responders during treatment)) after 12 weeks of treatment. Conversely, patients who show no acute effect do not have a positive response during long-term therapy. In other words, the results of the acute pharmacologic effect correspond to the effect during long-term therapy. 5. Aim of the study: The main aim of the study is to develop a method that allows responders to be distinguished from non-responders before long-term treatment is initiated. Subsidiary aims are to record changes in pulmonary functional parameters, NO concentrations and peak flow variability, the use of beta2 sympathomimetics and the asthma symptom score. 6. Patient selection: The study will include approximately 30 patients aged 6 to 14 years with diagnosed bronchial asthma who have been on constant anti-inflammatory therapy for at least four weeks (GINA classes 2 and 3). 7. Study design: This investigation is a single-center, two-phase, single-arm study. In order to detect a potential placebo effect, the treatment phase will be preceded by a single-blinded two-week placebo run-in phase, followed by a 12 week open-label treatment phase.</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:ae4603f3fc5a99089bfc5c5d23cd2f12' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Children and adolescents with symptomatic bronchial asthma despite ongoing therapy</li>\n<li>Age 6-14 years</li>\n<li>Asthma diagnosed at lease six months previously (by a special pulmonary allergologic outpatient unit)</li>\n<li>Demonstration of reversibility (FEV1 increased by at least 12% after bronchospasmolysis with a beta2 sympathomimetic). This can be determined at the screening visit or within the previous three months.</li>\n<li>Patients who are either steroid-naive or who received constant doses of the following medi&#172;cations within the previous four weeks:\n<ul>\n<li>Beclomethasone dipropionate: up to 400 &#181;g daily</li>\n<li>Fluticasone propionate: up to 200 &#181;g daily</li>\n<li>Budesonide: up to 400 &#181;g daily</li>\n</ul>\n</li>\n<li>Patients who are able to reliably complete the asthma diary and perform peak flow measurements according to instructions.</li>\n<li>Girls of childbearing potential must have acceptable methods of contraceptions, including sexual abstinence.</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Patients who were treated with systemic steroids within the previous 30 days</li>\n<li>Patients using one of the following asthma medications:\n<ul>\n<li>Systemic steroids</li>\n<li>Nedocromil, DNCG</li>\n<li>Theophylline</li>\n<li>Ketotifen</li>\n<li>Systemic or long-acting beta2 sympathomimetics</li>\n</ul>\n</li>\n<li>Patients who have experienced one of the following events within the previous 30 days:\n<ul>\n<li>A change in asthma medication</li>\n<li>Pulmonary infection</li>\n<li>Hospitalization due to bronchial asthma or any other respiratory condition</li>\n</ul>\n</li>\n<li>Patients who are currently participating in another clinical trial or have done so within the previous 30 days.</li>\n<li>Patients known or expected to react hypersensitively to components of the investigational medication</li>\n<li>Patients receiving Phenobarbital, Phenytoin, Rifampicin (medications that are metabolized by Cytochrom P450</li>\n<li>Patients with analgetic intolerance</li>\n<li>Pregnant females</li>\n</ul>\n</p>', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:11997dbe7e23386772f28e59eddfc1f2' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Asthma is a chronic inflammatory disease, affecting up to 10 % of the general population in developed countries. Corticosteroids are necessary to control symptoms, but induce adverse events sometimes intolerable. In severe asthma, which represent 5 to 10% of global asthma, corticosteroids frequently fail to prevent severe exacerbations, leading to emergency care, hospitalization and sometimes death. The aim of this study is to identify predictive factors specific for exacerbation outcome which will lead to a minor increase in treatment in order to prevent exacerbations, while minimizing drug adverse effects.</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:85e10626cbe9c5cd3775c139c4a2b6f1' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Predictive Factors for Exacerbation Outcome in Severe Refractory Asthmatics</p>\n', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:d5a3db33341851679adccce2eb23fa0b' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion criteria :\n<ul>\n<li>Male or female adults aged &#8805; 18 years, who have signed an Inform Consent Form prior to initiation of any study-related procedure</li>\n<li>Patients with severe asthma with at least 2 exacerbations during the last 12 months that necessitated oral cortico-therapy or increase in oral cortico-therapy</li>\n</ul>\n</p><p> Exclusion criteria :\n<ul>\n<li>Pregnant or nursing women</li>\n<li>Patients with other chronic inflammatory lung disease</li>\n<li>Current smoker or a smoking history of 10 pack years or more</li>\n</ul>\n</p>', created = 1283571715, expire = 1283658115, headers = '', serialized = 0 WHERE cid = '1:add765229cd3751c30f8cb66ffc1291e' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>We plan to use the Life Shirt to record tidal volume, respiratory rate and breathing pattern over a 6 hour period in patients admitted with difficult asthma. The Life Shirt will also be used to collect the same data over the same time period in a group of healthy controls. This data will then be correlated with the assessment of the supervising consultant as to whether the patient has any element of dysfunctional breathing contributing to their symptoms. It is hoped that the data obtained may in future be used to offer treatment to those patients with dysfunctional breathing.</p>\n', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:e5abccfbe03d183c70e4e36023020bc9' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Ambulatory Respiratory Inductance Plethysmography (RIP). Can it be Used to Help Identify Dysfunctional Breathing in Difficult Asthma?</p>\n', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:0b7254c8adf7f956b1451236a759b43a' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Hypothesis Dysfunctional breathing patterns are more prevalent in patients with a diagnosis of difficult to treat asthma than healthy volunteers. Design This will be an open, prospective study, recruiting sequential patients admitted electively to undergo the difficult asthma protocol (DAP). These patients are generally admitted during a period of stability, but still have significant symptoms despite asthma therapy. Healthy volunteers will be recruited from hospital staff and their family and friends. We will recruit patients over a 12 to 18 month period and hope to enrol 60 patients. On the final day of their 4 day admission, patients will be asked to wear the life vest from 0800hrs. During the morning they will undergo a 6 minute walk to test to assess their responses during exercise. They will also be reviewed by the supervising consultant to discuss the results of their investigations. While wearing the shirt, the patient will be asked to keep a diary of their activities and symptoms. The Life Shirt can be removed by the patient at the time of discharge. 20 Healthy volunteers will be recruited from the hospital staff. They will be asked to wear the life vest while undertaking their normal daily activities. They will also undertake a 6 minute walk test. Tidal volume, minute volume and respiratory rate will be recorded at rest and during exertion, aided by the patient diary. Breathing pattern and features of dysfunctional breathing, such as frequent sighs, will also be noted. This will subsequently be correlated with the assessment of the supervising consultant with regard to the presence of dysfunctional breathing. Data will also be analysed with regard to whether there are any differences between healthy volunteers, patients felt to have asthma, and those felt not to have asthma by their admitting consultant.</p>\n', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:1361ad692cd8e4b80b8df36a85c294ec' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>Physician diagnosis of difficult asthma</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>Current breastfeeding</li>\n</ul>\n</p>', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:f1a844311d936bd1b81e7b8ccf706fe0' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>&nbsp;</p>\n', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:cc7819055cde3194bb3b136bad5cf58d' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Inclusion Criteria:\n<ul>\n<li>diagnosed with asthma</li>\n</ul>\n</p><p> Exclusion Criteria:\n<ul>\n<li>patients with copd</li>\n</ul>\n</p>', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:80cb3ab02efed37352dcd81bd6dd8275' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>This study aims to document prospectively the incidence of allergies of eczema, asthma and allergic rhinitis in 2 diverse cohorts (Singaporean and Indonesian) with contrasting lifestyles and socioeconomic development. The profile of microbial colonization in terms of species variety, as well as their genetic diversity will be studied in Singapore and Indonesia cohorts and to correlate these with clinical allergy.</p>\n', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:2f012613ee89c3084d7944c3a31bd1f9' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>The purpose of this study is to determine the efficacy of an anti-asthma herbal medicine intervention (ASHMI) in adult asthmatics</p>\n', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:26fbe59666d121596f5a15fb03c7f4ad' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Asthma symptoms [&nbsp;Time&nbsp;Frame:&nbsp;12 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:318ff0178fb7930bb91a68dc907ef44c' in /persistent/html/includes/cache.inc on line 109.
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  • user warning: Table './intheclinic/cache_filter' is marked as crashed and should be repaired query: UPDATE cache_filter SET data = '<p>Acute asthma-related resource utilization [&nbsp;Time&nbsp;Frame:&nbsp;12 weeks&nbsp;] [&nbsp;Designated&nbsp;as&nbsp;safety&nbsp;issue:&nbsp;No&nbsp;]</p>\n', created = 1283571716, expire = 1283658116, headers = '', serialized = 0 WHERE cid = '1:2c68e7f7db639de09e6ca91799958188' in /persistent/html/includes/cache.inc on line 109.
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Developing Asthma Interventions Using Community Based Research

Recruitment status: 
Recruiting

The purpose of this study is to identify community resources and challenges in improving the health of community members with asthma. The primary goal of this project is to use Community-Based Participatory Research methodology to develop interventions aimed at improving asthma management in high-risk African American asthmatics. This "ground-up" longterm approach has never been tested before in asthmatics. The primary goal of this study will be accomplished with four specific aims: Aim 1. Conduct focus groups to identify barriers to asthma management in the target population. Aim 2. Use a community advisory board (CAB) consisting of participants selected from the various focus groups to gather information about solutions for the above barriers. Aim 3. Use the information from the CAB to develop an intervention to improve asthma self management behaviors in the target population. Aim 4. Refine the developed intervention based on feedback from focus groups conducted in Aim 1.

Background information
Trial ID: 
NCT00728169
Other unique IDs: 
020715JEM13314
P20RR011792
Official title: 

Feasibility of Developing an Effective Asthma Intervention Using CBPR Methods

Detailed description: 

Volunteer will be asked to respond to several questions that address their perceptions about asthma. Volunteers will also be asked to discuss their beliefs about asthma. Everyone in the group will be given an opportunity to answer questions. Volunteers can decide that they no longer want to participate in the group discussion at any time. The discussion will last from 1.5 - 2 hours. The focus group discussion will have a maximum of 10 people. We will be audio and video taping the discussion so that we do not miss any information that volunteers share with us.

Number to be enrolled: 
62 patients

Study Evaluating the Effect of IMA-026 on Allergen-Induced Late Asthma Response in Mild Asthma

Trial phase: 
Phase I
Recruitment status: 
Not yet recruiting

The purpose of this study is to evaluate the effect of IMA-026, an antibody to IL-13, on airway hyperresponsiveness and airway inflammation in mild asthmatics. IMA-026 will be given as 2 injections under the skin 1 week apart at 2 mg/kg each dose. The study will include a screening period and a treatment period which includes doses on day 1 and day 8.

Background information
Trial ID: 
NCT00725582
Other unique IDs: 
3192K1-1002
Official title: 

The Effects of IMA-026 on Allergen-Induced Airway Responses and Airway Inflammation in Subjects With Mild Atopic Asthma

Detailed description: 

 

Number to be enrolled: 
24 patients

PF-04191834 Single Dose Bronchodilatory Study In Asthma.

Trial phase: 
Phase II
Recruitment status: 
Recruiting

Study to determine the bronchodilatory effects of PF-04191834 compared with zileuton in patients with asthma

Background information
Trial ID: 
NCT00723021
Other unique IDs: 
B0041002
Official title: 

A Phase 2a, Randomised, Double-Blind (3rd Party Open), Double-Dummy, Placebo And Active Controlled 5-Way Crossover Study To Assess The Bronchodilatory Action, Safety, Toleration And Pharmacokinetics Of Single Oral Doses Of PF-04191834 In Asthmatic Patient

Detailed description: 

 

Number to be enrolled: 
15 patients

HFCWO in Hospitalized Asthmatic Children

To determine whether or not high frequency chest wall oscillation (in the form of the VestTM) is superior to regular asthma therapy in the management of children hospitalized with moderate to severe asthma.

Background information
Other unique IDs: 
CR-0078

Investigation to Identify Predictors of Response to a Treatment With Montelukast

Trial phase: 
Phase IV
Recruitment status: 
Recruiting

The main aim of the study is to develop a method that allows responders to be distinguished from non-responders before long-term treatment is initiated. Subsidiary aims are to record changes in pulmonary functional parameters, NO concentrations and peak flow variability, the use of beta2 sympathomimetics and the asthma symptom score.

Background information
Trial ID: 
NCT00721240
Other unique IDs: 
Trial No. 25.08.2005
Official title: 

Investigation to Identify Predictors of Response to a Treatment With Montelukast

Detailed description: 

Leukotriene antagonists (montelukast) are particularly effective as controllers before exposure to an allergen (Leff 1998). The same applies to the treatment of bronchoconstriction induced by physical exertion or cold air (Richter 2000). Montelukast binds to the cysteinyl leuko¬triene-1 receptor, where it prevents leukotriene from binding. Leukotrienes play a key role as mediators in inflammatory processes. By binding to the receptor they cause, among other things, edema, damage to the bronchial epithelium and bronchoconstriction.

Number to be enrolled: 
50 patients

Predictive Factors for Exacerbation Outcome in Severe Refractory Asthmatics

Recruitment status: 
Recruiting

Asthma is a chronic inflammatory disease, affecting up to 10 % of the general population in developed countries. Corticosteroids are necessary to control symptoms, but induce adverse events sometimes intolerable. In severe asthma, which represent 5 to 10% of global asthma, corticosteroids frequently fail to prevent severe exacerbations, leading to emergency care, hospitalization and sometimes death. The aim of this study is to identify predictive factors specific for exacerbation outcome which will lead to a minor increase in treatment in order to prevent exacerbations, while minimizing drug adverse effects.

Background information
Trial ID: 
NCT00721097
Other unique IDs: 
BRD 07/6-X
Official title: 

Predictive Factors for Exacerbation Outcome in Severe Refractory Asthmatics

Detailed description: 

 

Number to be enrolled: 
45 patients
Acronym: 
EXPRESA

Dysfunctional Breathing in Difficult Asthma.

Recruitment status: 
Recruiting

We plan to use the Life Shirt to record tidal volume, respiratory rate and breathing pattern over a 6 hour period in patients admitted with difficult asthma. The Life Shirt will also be used to collect the same data over the same time period in a group of healthy controls. This data will then be correlated with the assessment of the supervising consultant as to whether the patient has any element of dysfunctional breathing contributing to their symptoms. It is hoped that the data obtained may in future be used to offer treatment to those patients with dysfunctional breathing.

Background information
Trial ID: 
NCT00716677
Other unique IDs: 
08/H0708/35
Official title: 

Ambulatory Respiratory Inductance Plethysmography (RIP). Can it be Used to Help Identify Dysfunctional Breathing in Difficult Asthma?

Detailed description: 

Hypothesis Dysfunctional breathing patterns are more prevalent in patients with a diagnosis of difficult to treat asthma than healthy volunteers. Design This will be an open, prospective study, recruiting sequential patients admitted electively to undergo the difficult asthma protocol (DAP). These patients are generally admitted during a period of stability, but still have significant symptoms despite asthma therapy. Healthy volunteers will be recruited from hospital staff and their family and friends. We will recruit patients over a 12 to 18 month period and hope to enrol 60 patients.

Number to be enrolled: 
80 patients

CARE - Quality Improvement in Asthma Secondary Prevention in Primary Care, Through Delegation of Consultations to the Nurse.

Recruitment status: 
Recruiting

Quality Improvement in Primary Care: delegation of check-ups to nurses in general practice

Background information
Trial ID: 
NCT00714038
Other unique IDs: 
NIS-RDK-DUM-2008/1
Official title: 

CARE - Quality Development in Asthma in General Practice

Detailed description: 

 

Number to be enrolled: 
2000 patients

Study of Stool Microbiota in Two Diverse Cohorts of Asian and Its Influence on Allergy Development

This study aims to document prospectively the incidence of allergies of eczema, asthma and allergic rhinitis in 2 diverse cohorts (Singaporean and Indonesian) with contrasting lifestyles and socioeconomic development. The profile of microbial colonization in terms of species variety, as well as their genetic diversity will be studied in Singapore and Indonesia cohorts and to correlate these with clinical allergy.

Background information
Other unique IDs: 
SQNB01

Effectiveness of Chinese Herbal Therapy for Asthma

The purpose of this study is to determine the efficacy of an anti-asthma herbal medicine intervention (ASHMI) in adult asthmatics

Background information
Other unique IDs: 
P01 AT002647_2
5 P01 AT 002647-02
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